Dose escalation randomised study of efmarodocokin alfa in healthy volunteers and patients with ulcerative colitis

por Wagner, Frank, Mansfield, John C, Lekkerkerker, Annemarie N, Wang, Yehong, Keir, Mary, Dash, Ajit, Butcher, Brandon, Harder, Brandon, Orozco, Luz D, Mar, Jordan S, Chen, Hao, Rothenberg, Michael E
Publicado 2023

IL-22 alters gut microbiota composition and function to increase aryl hydrocarbon receptor activity in mice and humans

por Mar, Jordan S., Ota, Naruhisa, Pokorzynski, Nick D., Peng, Yutian, Jaochico, Allan, Sangaraju, Dewakar, Skippington, Elizabeth, Lekkerkerker, Annemarie N., Rothenberg, Michael E., Tan, Man-Wah, Yi, Tangsheng, Keir, Mary E.
Publicado 2023

A phase I, randomized, ascending‐dose study to assess safety, pharmacokinetics, and activity of GDC‐8264, a RIP1 inhibitor, in healthy volunteers

por Jones, Nicholas S., Kshirsagar, Smita, Mohanan, Vishnu, Ramakrishnan, Vidya, Di Nucci, Flavia, Ma, Ling, Mao, Jialin, Ding, Hao, Klabunde, Sha, Vucic, Domagoj, Pan, Lin, Lekkerkerker, Annemarie N., Chen, Yuan, Rothenberg, Michael E.
Publicado 2023

SAkuraBONSAI: Protocol design of a novel, prospective study to explore clinical, imaging, and biomarker outcomes in patients with AQP4-IgG-seropositive neuromyelitis optica spectru...

por Bennett, Jeffrey L., Fujihara, Kazuo, Kim, Ho Jin, Marignier, Romain, O'Connor, Kevin C., Sergott, Robert C., Traboulsee, Anthony, Wiendl, Heinz, Wuerfel, Jens, Zamvil, Scott S., Anania, Veronica G., Buffels, Regine, Künzel, Thomas, Lekkerkerker, Annemarie N., Lennon-Chrimes, Siân, Pittock, Sean J.
Publicado 2023

Astegolimab or Efmarodocokin Alfa in Patients With Severe COVID-19 Pneumonia: A Randomized, Phase 2 Trial*

por Waters, Michael, McKinnell, James A., Kalil, Andre C., Martin, Greg S., Buchman, Timothy G., Theess, Wiebke, Yang, Xiaoying, Lekkerkerker, Annemarie N., Staton, Tracy, Rosenberger, Carrie M., Pappu, Rajita, Wang, Yehong, Zhang, Wenhui, Brooks, Logan, Cheung, Dorothy, Galanter, Joshua, Chen, Hubert, Mohan, Divya, Peck, Melicent C.
Publicado 2022