Animal Models for the Study of Gaucher Disease

por Cabasso, Or, Kuppuramalingam, Aparna, Lelieveld, Lindsey, Van der Lienden, Martijn, Boot, Rolf, Aerts, Johannes M., Horowitz, Mia
Publicado 2023

Xylose‐Configured Cyclophellitols as Selective Inhibitors for Glucocerebrosidase

por Su, Qin, Schröder, Sybrin P., Lelieveld, Lindsey T., Ferraz, Maria J., Verhoek, Marri, Boot, Rolf G., Overkleeft, Herman S., Aerts, Johannes M. F. G., Artola, Marta, Kuo, Chi‐Lin
Publicado 2021

Total Chemical Synthesis of SUMO and SUMO‐Based Probes for Profiling the Activity of SUMO‐Specific Proteases

por Mulder, Monique P. C., Merkx, Remco, Witting, Katharina F., Hameed, Dharjath S., El Atmioui, Dris, Lelieveld, Lindsey, Liebelt, Frauke, Neefjes, Jacques, Berlin, Ilana, Vertegaal, Alfred C. O., Ovaa, Huib
Publicado 2018

Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish

por Artola, Marta, Kuo, Chi-Lin, Lelieveld, Lindsey T., Rowland, Rhianna J., van der Marel, Gijsbert A., Codée, Jeroen D. C., Boot, Rolf G., Davies, Gideon J., Aerts, Johannes M. F. G., Overkleeft, Herman S.
Publicado 2019

In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity‐based protein profiling

por Kuo, Chi‐Lin, Kallemeijn, Wouter W., Lelieveld, Lindsey T., Mirzaian, Mina, Zoutendijk, Iris, Vardi, Ayelet, Futerman, Anthony H., Meijer, Annemarie H., Spaink, Herman P., Overkleeft, Herman S., Aerts, Johannes M.F.G., Artola, Marta
Publicado 2019

Gaucher disease protects against tuberculosis

por Fan, Jingwen, Hale, Victoria L., Lelieveld, Lindsey T., Whitworth, Laura J., Busch-Nentwich, Elisabeth M., Troll, Mark, Edelstein, Paul H., Cox, Timothy M., Roca, Francisco J., Aerts, Johannes M. F. G., Ramakrishnan, Lalita
Publicado 2023

Consequences of excessive glucosylsphingosine in glucocerebrosidase-deficient zebrafish.

por Lelieveld, Lindsey T., Gerhardt, Sophie, Maas, Saskia, Zwiers, Kimberley C., de Wit, Claire, Beijk, Ernst H., Ferraz, Maria J., Artola, Marta, Meijer, Annemarie H., Tudorache, Christian, Salvatori, Daniela, Boot, Rolf G., Aerts, Johannes M.F.G.
Publicado 2022

1,6-epi-Cyclophellitol Cyclosulfamidate Is a Bona Fide Lysosomal α-Glucosidase Stabilizer for the Treatment of Pompe Disease

por Kok, Ken, Kuo, Chi-Lin, Katzy, Rebecca E., Lelieveld, Lindsey T., Wu, Liang, Roig-Zamboni, Véronique, van der Marel, Gijsbert A., Codée, Jeroen D. C., Sulzenbacher, Gerlind, Davies, Gideon J., Overkleeft, Herman S., Aerts, Johannes M. F. G., Artola, Marta
Publicado 2022