Activity of Clinically Relevant Antimalarial Drugs on Plasmodium falciparum Mature Gametocytes in an ATP Bioluminescence “Transmission Blocking” Assay

por Lelièvre, Joël, Almela, Maria Jesus, Lozano, Sonia, Miguel, Celia, Franco, Virginia, Leroy, Didier, Herreros, Esperanza
Publicado 2012

Activity of clinically relevant antimalarial drugs on Plasmodium falciparum mature gametocytes in an ATP bioluminescence “transmission blocking” assay

por Lelièvre, Joël, Almela, Maria Jesus, Lozano, Sonia, Miguel, Celia, Franco, Virginia, Leroy, Didier, Herreros, Esperanza
Publicado 2012

Development of a whole‐cell high‐throughput phenotypic screen to identify inhibitors of mycobacterial amino acid biosynthesis

por Burke, Christopher, Abrahams, Katherine A., Richardson, Emily J., Loman, Nicholas J., Alemparte, Carlos, Lelievre, Joel, Besra, Gurdyal S.
Publicado 2019

A New Set of Chemical Starting Points with Plasmodium falciparum Transmission-Blocking Potential for Antimalarial Drug Discovery

por Almela, Maria Jesus, Lozano, Sonia, Lelièvre, Joël, Colmenarejo, Gonzalo, Coterón, José Miguel, Rodrigues, Janneth, Gonzalez, Carolina, Herreros, Esperanza
Publicado 2015

Collaborative approaches for Target ID in neglected diseases: identifying new antimalarial targets

por Lafuente, Maria Jose, Guidelli-Disse, Sonja, Selenski, Carolyn, Lelievre, Joel, Willson, Timothy, Gamo, Francisco Javier, Drewes, Gerard, Vandal, Omar, Ballell-Pages, Luis
Publicado 2014

A novel validated assay to support the discovery of new anti-malarial gametocytocidal agents

por Bahamontes-Rosa, Noemí, Gomez-Lorenzo, María G., Lelièvre, Joël, Rodriguez Alejandre, Ane, Almela, María Jesus, Lozano, Sonia, Herreros, Esperanza, Gamo, Francisco-Javier
Publicado 2016

Evidence for the Contribution of the Hemozoin Synthesis Pathway of the Murine Plasmodium yoelii to the Resistance to Artemisinin-Related Drugs

por Witkowski, Benoit, Lelièvre, Joel, Nicolau-Travers, Marie-Laure, Iriart, Xavier, Njomnang Soh, Patrice, Bousejra-ElGarah, Fatima, Meunier, Bernard, Berry, Antoine, Benoit-Vical, Françoise
Publicado 2012

Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach

por Mugumbate, Grace, Mendes, Vitor, Blaszczyk, Michal, Sabbah, Mohamad, Papadatos, George, Lelievre, Joel, Ballell, Lluis, Barros, David, Abell, Chris, Blundell, Tom L., Overington, John P.
Publicado 2017

Development of a novel secondary phenotypic screen to identify hits within the mycobacterial protein synthesis pipeline

por Burke, Christopher, Jankute, Monika, Moynihan, Patrick, Gonzalez del Rio, Ruben, Li, Xiaojun, Esquivias, Jorge, Lelièvre, Joël, Cox, Jonathan A. G., Sacchettini, James, Besra, Gurdyal S.
Publicado 2020

A Leucyl-tRNA Synthetase Inhibitor with Broad-Spectrum Antimycobacterial Activity

por Ganapathy, Uday S., González del Rio, Rubén, Cacho-Izquierdo, Mónica, Ortega, Fátima, Lelièvre, Joël, Barros-Aguirre, David, Lindman, Marissa, Dartois, Véronique, Gengenbacher, Martin, Dick, Thomas
Publicado 2021

The multi-target aspect of an MmpL3 inhibitor: The BM212 series of compounds bind EthR2, a transcriptional regulator of ethionamide activation

por Moorey, Alice R., Cabanillas, Alejandro, Batt, Sarah M., Ghidelli-Disse, Sonja, Urones, Beatriz, Sanz, Olalla, Lelievre, Joel, Bantscheff, Marcus, Cox, Liam R., Besra, Gurdyal S.
Publicado 2021

Red blood cells derived from peripheral blood and bone marrow CD34+ human haematopoietic stem cells are permissive to Plasmodium parasites infection

por Fernandez-Becerra, Carmen, Lelievre, Joel, Ferrer, Mireia, Anton, Nuria, Thomson, Richard, Peligero, Cristina, Almela, Maria Jesus, Lacerda, Marcus VG, Herreros, Esperanza, del Portillo, Hernando A
Publicado 2013

Assay development and inhibition of the Mt-DprE2 essential reductase from Mycobacterium tuberculosis

por Batt, Sarah M., Toth, Szilvi, Rodriguez, Beatriz, Abrahams, Katherine A., Veerapen, Natacha, Chiodarelli, Giacomo, Cox, Liam R., Moynihan, Patrick J., Lelievre, Joel, Fütterer, Klaus, Besra, Gurdyal S.
Publicado 2023

Combinations of β-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis Infection

por Rullas, Joaquín, Dhar, Neeraj, McKinney, John D., García-Pérez, Adolfo, Lelievre, Joël, Diacon, Andreas H., Hugonnet, Jean-Emmanuel, Arthur, Michel, Angulo-Barturen, Iñigo, Barros-Aguirre, David, Ballell, Lluís
Publicado 2015

Mycobacterial Dihydrofolate Reductase Inhibitors Identified Using Chemogenomic Methods and In Vitro Validation

por Mugumbate, Grace, Abrahams, Katherine A., Cox, Jonathan A. G., Papadatos, George, van Westen, Gerard, Lelièvre, Joël, Calus, Szymon T., Loman, Nicholas J., Ballell, Lluis, Barros, David, Overington, John P., Besra, Gurdyal S.
Publicado 2015

Antimycobacterial drug discovery using Mycobacteria-infected amoebae identifies anti-infectives and new molecular targets

por Trofimov, Valentin, Kicka, Sébastien, Mucaria, Sabrina, Hanna, Nabil, Ramon-Olayo, Fernando, Del Peral, Laura Vela-Gonzalez, Lelièvre, Joël, Ballell, Lluís, Scapozza, Leonardo, Besra, Gurdyal S., Cox, Jonathan A. G., Soldati, Thierry
Publicado 2018

A Mycobacterium tuberculosis NBTI DNA Gyrase Inhibitor Is Active against Mycobacterium abscessus

por Ganapathy, Uday S., del Río, Rubén González, Cacho-Izquierdo, Mónica, Ortega, Fátima, Lelièvre, Joël, Barros-Aguirre, David, Aragaw, Wassihun Wedajo, Zimmerman, Matthew D., Lindman, Marissa, Dartois, Véronique, Gengenbacher, Martin, Dick, Thomas
Publicado 2021

Activity of Oral Tebipenem-Avibactam in a Mouse Model of Mycobacterium abscessus Lung Infection

por Negatu, Dereje A., González del Río, Rubén, Cacho-Izquierdo, Mónica, Barros-Aguirre, David, Lelievre, Joël, Rullas, Joaquín, Casado, Patricia, Ganapathy, Uday S., Zimmerman, Matthew D., Gengenbacher, Martin, Dartois, Véronique, Dick, Thomas
Publicado 2023

Identification and characterization of aspartyl-tRNA synthetase inhibitors against Mycobacterium tuberculosis by an integrated whole-cell target-based approach

por Soto, Ramón, Perez-Herran, Esther, Rodriguez, Beatriz, Duma, Bogdan M., Cacho-Izquierdo, Monica, Mendoza-Losana, Alfonso, Lelievre, Joel, Aguirre, David Barros, Ballell, Lluis, Cox, Liam R., Alderwick, Luke J., Besra, Gurdyal S.
Publicado 2018

Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen

por Cox, Jonathan A. G., Mugumbate, Grace, Del Peral, Laura Vela-Glez, Jankute, Monika, Abrahams, Katherine A., Jervis, Peter, Jackenkroll, Stefan, Perez, Arancha, Alemparte, Carlos, Esquivias, Jorge, Lelièvre, Joël, Ramon, Fernando, Barros, David, Ballell, Lluis, Besra, Gurdyal S.
Publicado 2016