Cleavage of mitochondrial homeostasis regulator PGAM5 by the intramembrane protease PARL is governed by transmembrane helix dynamics and oligomeric state

por Siebert, Verena, Silber, Mara, Heuten, Elena, Muhle-Goll, Claudia, Lemberg, Marius K.
Publicado 2022

Cooperation of mitochondrial and ER factors in quality control of tail-anchored proteins

por Dederer, Verena, Khmelinskii, Anton, Huhn, Anna Gesine, Okreglak, Voytek, Knop, Michael, Lemberg, Marius K
Publicado 2019

Rhomboid protease RHBDL4 promotes retrotranslocation of aggregation-prone proteins for degradation

por Bock, Josephine, Kühnle, Nathalie, Knopf, Julia D., Landscheidt, Nina, Lee, Jin-Gu, Ye, Yihong, Lemberg, Marius K.
Publicado 2022

Rhomboid-catalyzed intramembrane proteolysis requires hydrophobic matching with the surrounding lipid bilayer

por Engberg, Oskar, Ulbricht, David, Döbel, Viola, Siebert, Verena, Frie, Christian, Penk, Anja, Lemberg, Marius K., Huster, Daniel
Publicado 2022

Incomplete proteasomal degradation of green fluorescent proteins in the context of tandem fluorescent protein timers

por Khmelinskii, Anton, Meurer, Matthias, Ho, Chi-Ting, Besenbeck, Birgit, Füller, Julia, Lemberg, Marius K., Bukau, Bernd, Mogk, Axel, Knop, Michael
Publicado 2016

Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα

por Wunderle, Lina, Knopf, Julia D., Kühnle, Nathalie, Morlé, Aymeric, Hehn, Beate, Adrain, Colin, Strisovsky, Kvido, Freeman, Matthew, Lemberg, Marius K.
Publicado 2016

Chemical Blockage of the Mitochondrial Rhomboid Protease PARL by Novel Ketoamide Inhibitors Reveals Its Role in PINK1/Parkin-Dependent Mitophagy

por Poláchová, Edita, Bach, Kathrin, Heuten, Elena, Stanchev, Stancho, Tichá, Anežka, Lampe, Philipp, Majer, Pavel, Langer, Thomas, Lemberg, Marius K., Stříšovský, Kvido
Publicado 2022

CRISPR-Cas12a–assisted PCR tagging of mammalian genes

por Fueller, Julia, Herbst, Konrad, Meurer, Matthias, Gubicza, Krisztina, Kurtulmus, Bahtiyar, Knopf, Julia D., Kirrmaier, Daniel, Buchmuller, Benjamin C., Pereira, Gislene, Lemberg, Marius K., Knop, Michael
Publicado 2020

Insights into the catalytic properties of the mitochondrial rhomboid protease PARL

por Lysyk, Laine, Brassard, Raelynn, Arutyunova, Elena, Siebert, Verena, Jiang, Zhenze, Takyi, Emmanuella, Morrison, Melissa, Young, Howard S., Lemberg, Marius K., O’Donoghue, Anthony J., Lemieux, M. Joanne
Publicado 2021