Heterogeneous disease progression and treatment response in a C3HeB/FeJ mouse model of tuberculosis

por Lanoix, Jean-Philippe, Lenaerts, Anne J., Nuermberger, Eric L.
Publicado 2015

Effects of P-MAPA Immunomodulator on Toll-Like Receptors and p53: Potential Therapeutic Strategies for Infectious Diseases and Cancer

por Fávaro, Wagner J, Nunes, Odilon S, Seiva, Fabio RF, Nunes, Iseu S, Woolhiser, Lisa K, Durán, Nelson, Lenaerts, Anne J
Publicado 2012

In vitro and in vivo Evaluation of Synergism between Anti-Tubercular Spectinamides and Non-Classical Tuberculosis Antibiotics

por Bruhn, David F., Scherman, Michael S., Liu, Jiuyu, Scherbakov, Dimitri, Meibohm, Bernd, Böttger, Erik C., Lenaerts, Anne J., Lee, Richard E.
Publicado 2015

Location of Intra- and Extracellular M. tuberculosis Populations in Lungs of Mice and Guinea Pigs during Disease Progression and after Drug Treatment

por Hoff, Donald R., Ryan, Gavin J., Driver, Emily R., Ssemakulu, Cornelius C., De Groote, Mary A., Basaraba, Randall J., Lenaerts, Anne J.
Publicado 2011

Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis

por Irwin, Scott M., Driver, Emily, Lyon, Edward, Schrupp, Christopher, Ryan, Gavin, Gonzalez-Juarrero, Mercedes, Basaraba, Randall J., Nuermberger, Eric L., Lenaerts, Anne J.
Publicado 2015

Host Directed Therapy for Chronic Tuberculosis via Intrapulmonary Delivery of Aerosolized Peptide Inhibitors Targeting the IL-10-STAT3 Pathway

por Upadhyay, Rashmi, Sanchez-Hidalgo, Andrea, Wilusz, Carol J., Lenaerts, Anne J., Arab, Jennifer, Yeh, Joanna, Stefanisko, Karen, Tarasova, Nadya I., Gonzalez-Juarrero, Mercedes
Publicado 2018

Intracellular and in vivo evaluation of imidazo[2,1-b]thiazole-5-carboxamide anti-tuberculosis compounds

por Moraski, Garrett C., Deboosère, Nathalie, Marshall, Kate L., Weaver, Heath A., Vandeputte, Alexandre, Hastings, Courtney, Woolhiser, Lisa, Lenaerts, Anne J., Brodin, Priscille, Miller, Marvin J.
Publicado 2020

Multiple M. tuberculosis Phenotypes in Mouse and Guinea Pig Lung Tissue Revealed by a Dual-Staining Approach

por Ryan, Gavin J., Hoff, Donald R., Driver, Emily R., Voskuil, Martin I., Gonzalez-Juarrero, Mercedes, Basaraba, Randall J., Crick, Dean C., Spencer, John S., Lenaerts, Anne J.
Publicado 2010

Spectinamides are effective partner agents for the treatment of tuberculosis in multiple mouse infection models

por Robertson, Gregory T., Scherman, Michael S., Bruhn, David F., Liu, Jiuyu, Hastings, Courtney, McNeil, Michael R., Butler, Michelle M., Bowlin, Terry L., Lee, Robin B., Lee, Richard E., Lenaerts, Anne J.
Publicado 2017

Pentacyclic Nitrofurans with In Vivo Efficacy and Activity against Nonreplicating Mycobacterium tuberculosis

por Rakesh, Bruhn, David F., Scherman, Michael S., Woolhiser, Lisa K., Madhura, Dora B., Maddox, Marcus M., Singh, Aman P., Lee, Robin B., Hurdle, Julian G., McNeil, Michael R., Lenaerts, Anne J., Meibohm, Bernd, Lee, Richard E.
Publicado 2014

Digital Image Analysis of Heterogeneous Tuberculosis Pulmonary Pathology in Non-Clinical Animal Models using Deep Convolutional Neural Networks

por Asay, Bryce C., Edwards, Blake Blue, Andrews, Jenna, Ramey, Michelle E., Richard, Jameson D., Podell, Brendan K., Gutiérrez, Juan F. Muñoz, Frank, Chad B., Magunda, Forgivemore, Robertson, Gregory T., Lyons, Michael, Ben-Hur, Asa, Lenaerts, Anne J.
Publicado 2020

Drug distribution and efficacy of the DprE1 inhibitor BTZ-043 in the C3HeB/FeJ mouse tuberculosis model

por Ramey, Michelle E., Kaya, Firat, Bauman, Allison A., Massoudi, Lisa M., Sarathy, Jansy P., Zimmerman, Matthew D., Scott, Dashick W. L., Job, Alyx M., Miller-Dawson, Jake A., Podell, Brendan K., Lyons, Michael A., Dartois, Véronique, Lenaerts, Anne J., Robertson, Gregory T.
Publicado 2023

Bedaquiline and Pyrazinamide Treatment Responses Are Affected by Pulmonary Lesion Heterogeneity in Mycobacterium tuberculosis Infected C3HeB/FeJ Mice

por Irwin, Scott M., Prideaux, Brendan, Lyon, Edward R., Zimmerman, Matthew D., Brooks, Elizabeth J., Schrupp, Christopher A., Chen, Chao, Reichlen, Matthew J., Asay, Bryce C., Voskuil, Martin I., Nuermberger, Eric L., Andries, Koen, Lyons, Michael A., Dartois, Véronique, Lenaerts, Anne J.
Publicado 2016

Synthesis, Structure–Activity Relationship, and Mechanistic Studies of Aminoquinazolinones Displaying Antimycobacterial Activity

por Akester, Jessica N., Njaria, Paul, Nchinda, Aloysius, Le Manach, Claire, Myrick, Alissa, Singh, Vinayak, Lawrence, Nina, Njoroge, Mathew, Taylor, Dale, Moosa, Atica, Smith, Anthony J., Brooks, Elizabeth J., Lenaerts, Anne J., Robertson, Gregory T., Ioerger, Thomas R., Mueller, Rudolf, Chibale, Kelly
Publicado 2020

Spiropyrimidinetriones: a Class of DNA Gyrase Inhibitors with Activity against Mycobacterium tuberculosis and without Cross-Resistance to Fluoroquinolones

por Basarab, Gregory S., Ghorpade, Sandeep, Gibhard, Liezl, Mueller, Rudolf, Njoroge, Mathew, Peton, Nashied, Govender, Preshendren, Massoudi, Lisa M., Robertson, Gregory Thomas, Lenaerts, Anne J., Boshoff, Helena Ingrid, Joerss, Douglas, Parish, Tanya, Durand-Reville, Thomas F., Perros, Manos, Singh, Vinayak, Chibale, Kelly
Publicado 2022

INHIBITION OF MYCOLIC ACID TRANSPORT ACROSS THE MYCOBACTERIUM TUBERCULOSIS PLASMA MEMBRANE

por Grzegorzewicz, Anna E., Pham, Ha, Gundi, Vijay A. K. B., Scherman, Michael S., North, Elton J., Hess, Tamara, Jones, Victoria, Gruppo, Veronica, Born, Sarah E. M., Korduláková, Jana, Chavadi, Sivagami Sundaram, Morisseau, Christophe, Lenaerts, Anne J., Lee, Richard E., McNeil, Michael R., Jackson, Mary
Publicado 2012

Efficacy and Improved Resistance Potential of a Cofactor-Independent InhA Inhibitor of Mycobacterium tuberculosis in the C3HeB/FeJ Mouse Model

por Robertson, Gregory T., Ektnitphong, Victoria A., Scherman, Michael S., McNeil, Matthew B., Dennison, Devon, Korkegian, Aaron, Smith, Anthony J., Halladay, Jason, Carter, David S., Xia, Yi, Zhou, Yasheen, Choi, Wai, Berry, Pamela W., Mao, Weimin, Hernandez, Vincent, Alley, M. R. K., Parish, Tanya, Lenaerts, Anne J.
Publicado 2019

Comparative Analysis of Pharmacodynamics in the C3HeB/FeJ Mouse Tuberculosis Model for DprE1 Inhibitors TBA-7371, PBTZ169, and OPC-167832

por Robertson, Gregory T., Ramey, Michelle E., Massoudi, Lisa M., Carter, Claire L., Zimmerman, Matt, Kaya, Firat, Graham, Barbara G., Gruppo, Veronica, Hastings, Courtney, Woolhiser, Lisa K., Scott, Dashick W. L., Asay, Bryce C., Eshun-Wilson, Franceen, Maidj, Ekaterina, Podell, Brendan K., Vásquez, Joshua J., Lyons, Mike A., Dartois, Véronique, Lenaerts, Anne J.
Publicado 2021

Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA

por Xia, Yi, Zhou, Yasheen, Carter, David S, McNeil, Matthew B, Choi, Wai, Halladay, Jason, Berry, Pamela W, Mao, Weimin, Hernandez, Vincent, O'Malley, Theresa, Korkegian, Aaron, Sunde, Bjorn, Flint, Lindsay, Woolhiser, Lisa K, Scherman, Michael S, Gruppo, Veronica, Hastings, Courtney, Robertson, Gregory T, Ioerger, Thomas R, Sacchettini, Jim, Tonge, Peter J, Lenaerts, Anne J, Parish, Tanya, Alley, MRK
Publicado 2018

Spectinamides: A New Class of Semisynthetic Anti-Tuberculosis Agents that Overcome Native Drug Efflux

por Lee, Richard E., Hurdle, Julian G., Liu, Jiuyu, Bruhn, David F., Matt, Tanja, Scherman, Michael S., Vaddady, Pavan K, Zheng, Zhong, Qi, Jianjun, Akbergenov, Rashid, Das, Sourav, Madhura, Dora B., Rathi, Chetan, Trivedi, Ashit, Villellas, Cristina, Lee, Robin. B., Rakesh, Waidyarachchi, Samanthi L., Sun, Dianqing, McNeil, Michael R., Ainsa, Jose A., Boshoff, Helena I., Gonzalez-Juarrero, Mercedes, Meibohm, Bernd, Böttger, Erik C., Lenaerts, Anne J.
Publicado 2014