MTorc1 at the Crossroads of Facultative Intestinal Stem Cell Activation

por Lengner, Christopher J.
Publicado 2020

Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish

por Valvezan, Alexander J., Huang, Jian, Lengner, Christopher J., Pack, Michael, Klein, Peter S.
Publicado 2014

A System for Genome-Wide Histone Variant Dynamics In ES Cells Reveals Dynamic MacroH2A2 Replacement at Promoters

por Yildirim, Ozlem, Hung, Jui-Hung, Cedeno, Ryan J., Weng, Zhiping, Lengner, Christopher J., Rando, Oliver J.
Publicado 2014

Branched actin networks are assembled on microtubules by adenomatous polyposis coli for targeted membrane protrusion

por Efimova, Nadia, Yang, Changsong, Chia, Jonathan X., Li, Ning, Lengner, Christopher J., Neufeld, Kristi L., Svitkina, Tatyana M.
Publicado 2020

Single-Cell Analysis of Proxy Reporter Allele-Marked Epithelial Cells Establishes Intestinal Stem Cell Hierarchy

por Li, Ning, Yousefi, Maryam, Nakauka-Ddamba, Angela, Jain, Rajan, Tobias, John, Epstein, Jonathan A., Jensen, Shane T., Lengner, Christopher J.
Publicado 2014

Direct cell reprogramming is a stochastic process amenable to acceleration

por Hanna, Jacob, Saha, Krishanu, Pando, Bernardo, van Zon, Jeroen, Lengner, Christopher J., Creyghton, Menno P., van Oudenaarden, Alexander, Jaenisch, Rudolf
Publicado 2009

Calorie Restriction Governs Intestinal Epithelial Regeneration through Cell-Autonomous Regulation of mTORC1 in Reserve Stem Cells

por Yousefi, Maryam, Nakauka-Ddamba, Angela, Berry, Corbett T., Li, Ning, Schoenberger, Jenna, Simeonov, Kamen P., Cedeno, Ryan J., Yu, Zhengquan, Lengner, Christopher J.
Publicado 2018

Msi RNA-binding proteins control reserve intestinal stem cell quiescence

por Yousefi, Maryam, Li, Ning, Nakauka-Ddamba, Angela, Wang, Shan, Davidow, Kimberly, Schoenberger, Jenna, Yu, Zhengquan, Jensen, Shane T., Kharas, Michael G., Lengner, Christopher J.
Publicado 2016

Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids

por Kim, Hongwon, Park, Hyeok Ju, Choi, Hwan, Chang, Yujung, Park, Hanseul, Shin, Jaein, Kim, Junyeop, Lengner, Christopher J., Lee, Yong Kyu, Kim, Jongpil
Publicado 2019

Limitations to Understanding Intestinal Stem Cell Activity via Cre-Lox–Based Lineage Tracing

por Johnson, NICOLETTE M., Na, JEEYOON, Monaghan, KEARA E., Tang, ALAN T., Tian, YUHUA, Leu, NICOLAE A., Li, NING, Kahn, MARK L., Lengner, CHRISTOPHER J.
Publicado 2022

LIN28B promotes cell invasion and colorectal cancer metastasis via CLDN1 and NOTCH3

por Sugiura, Kensuke, Masuike, Yasunori, Suzuki, Kensuke, Shin, Alice E., Sakai, Nozomu, Matsubara, Hisahiro, Otsuka, Masayuki, Sims, Peter A., Lengner, Christopher J., Rustgi, Anil K.
Publicado 2023

Mouse Intestinal Krt15+ Crypt Cells Are Radio-Resistant and Tumor Initiating

por Giroux, Véronique, Stephan, Julien, Chatterji, Priya, Rhoades, Ben, Wileyto, E. Paul, Klein-Szanto, Andres J., Lengner, Christopher J., Hamilton, Kathryn E., Rustgi, Anil K.
Publicado 2018

Calorie Restriction Governs Intestinal Epithelial Regeneration through Cell-Autonomous Regulation of mTORC1 in Reserve Stem Cells

por Yousefi, Maryam, Nakauka-Ddamba, Angela, Berry, Corbett T., Li, Ning, Schoenberger, Jenna, Bankler-Jukes, Devon, Simeonov, Kamen P., Cedeno, Ryan J., Yu, Zhengquan, Lengner, Christopher J.
Publicado 2023

Osteoblast differentiation and skeletal development are regulated by Mdm2–p53 signaling

por Lengner, Christopher J., Steinman, Heather A., Gagnon, James, Smith, Thomas W., Henderson, Janet E., Kream, Barbara E., Stein, Gary S., Lian, Jane B., Jones, Stephen N.
Publicado 2006

BCR-Induced Ca(2+) Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells

por Berry, Corbett T., Liu, Xiaohong, Myles, Arpita, Nandi, Satabdi, Chen, Youhai H., Hershberg, Uri, Brodsky, Igor E., Cancro, Michael P., Lengner, Christopher J., May, Michael J., Freedman, Bruce D.
Publicado 2020

Telomerase expression marks transitional growth‐associated skeletal progenitor/stem cells

por Carlone, Diana L., Riba‐Wolman, Rebecca D., Deary, Luke T., Tovaglieri, Alessio, Jiang, Lijie, Ambruzs, Dana M., Mead, Benjamin E., Shah, Manasvi S., Lengner, Christopher J., Jaenisch, Rudolf, Breault, David T.
Publicado 2021

Transgenic Mice with Defined Combinations of Drug Inducible Reprogramming Factors

por Markoulaki, Styliani, Hanna, Jacob, Beard, Caroline, Carey, Bryce W., Cheng, Albert W., Lengner, Christopher J., Dausman, Jessica A., Fu, Dongdong, Gao, Qing, Wu, Su, Cassady, John P., Jaenisch, Rudolf
Publicado 2009

The Tumor Suppressor Adenomatous Polyposis Coli (apc) Is Required for Neural Crest-Dependent Craniofacial Development in Zebrafish

por Liu, Xiaolei, Jones, William D., Quesnel-Vallières, Mathieu, Devadiga, Sudhish A., Lorent, Kristin, Valvezan, Alexander J., Myers, Rebecca L., Li, Ning, Lengner, Christopher J., Barash, Yoseph, Pack, Michael, Klein, Peter S.
Publicado 2023

Transformation of the intestinal epithelium by the MSI2 RNA binding protein

por Wang, Shan, Li, Ning, Yousefi, Maryam, Nakauka-Ddamba, Angela, Li, Fan, Parada, Kimberly, Rao, Shilpa, Minuesa, Gerard, Katz, Yarden, Gregory, Brian D., Kharas, Michael G., Yu, Zhengquan, Lengner, Christopher J.
Publicado 2015

Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche

por Yang, Ting-Lin B., Chen, Qijun, Deng, Jennifer T., Jagannathan, Geetha, Tobias, John W., Schultz, David C., Wang, Shan, Lengner, Christopher J., Rustgi, Anil K., Lynch, John P., Johnson, F. Brad
Publicado 2017