Genetics of NLRP3 suggests lack of involvement and inefficient druggability in Parkinson’s disease

por Senkevich, Konstantin, Liu, Lang, Alvarado, Chelsea X., Leonard, Hampton L., Nalls, Mike A., Gan-Or, Ziv
Publicado 2023

Human brain single nucleus cell type enrichments in neurodegenerative diseases

por Alvarado, Chelsea X, Weller, Cory A., Johnson, Nicholas, Leonard, Hampton L., Singleton, Andrew B., Reed, Xylena, Blauewendraat, Cornelis, Nalls, Mike A
Publicado 2023

A population scale analysis of rare SNCA variation in the UK Biobank

por Blauwendraat, Cornelis, Makarious, Mary B., Leonard, Hampton L., Bandres-Ciga, Sara, Iwaki, Hirotaka, Nalls, Mike A., Noyce, Alastair J., Singleton, Andrew B.
Publicado 2020

Coding and Noncoding Variation in LRRK2 and Parkinson's Disease Risk

por Lake, Julie, Reed, Xylena, Langston, Rebekah G., Nalls, Mike A., Gan‐Or, Ziv, Cookson, Mark R., Singleton, Andrew B., Blauwendraat, Cornelis, Leonard, Hampton L.
Publicado 2021

RIC3 variants are not associated with Parkinson’s disease in large European, Latin American, or East Asian cohorts

por Brolin, Kajsa, Bandres-Ciga, Sara, Leonard, Hampton, Makarious, Mary B., Blauwendraat, Cornelis, Mata, Ignacio F, Foo, Jia Nee, Pihlstrøm, Lasse, Swanberg, Maria, Gan-Or, Ziv, Tan, Manuela MX
Publicado 2022

omicSynth: an Open Multi-omic Community Resource for Identifying Druggable Targets across Neurodegenerative Diseases

por Alvarado, Chelsea X., Makarious, Mary B., Weller, Cory A., Vitale, Dan, Koretsky, Mathew J., Bandres-Ciga, Sara, Iwaki, Hirotaka, Levine, Kristin, Singleton, Andrew, Faghri, Faraz, Nalls, Mike A., Leonard, Hampton L.
Publicado 2023

Genetic risk factor clustering within and across neurodegenerative diseases

por Koretsky, Mathew J, Alvarado, Chelsea, Makarious, Mary B, Vitale, Dan, Levine, Kristin, Bandres-Ciga, Sara, Dadu, Anant, Scholz, Sonja W, Sargent, Lana, Faghri, Faraz, Iwaki, Hirotaka, Blauwendraat, Cornelis, Singleton, Andrew, Nalls, Mike, Leonard, Hampton
Publicado 2023

Polygenic Resilience Modulates the Penetrance of Parkinson Disease Genetic Risk Factors

por Liu, Hui, Dehestani, Mohammad, Blauwendraat, Cornelis, Makarious, Mary B., Leonard, Hampton, Kim, Jonggeol J., Schulte, Claudia, Noyce, Alastair, Jacobs, Benjamin M., Foote, Isabelle, Sharma, Manu, Nalls, Mike, Singleton, Andrew, Gasser, Thomas, Bandres‐Ciga, Sara
Publicado 2022

Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits

por Gouveia, Mateus H., Bentley, Amy R., Leonard, Hampton, Meeks, Karlijn A. C., Ekoru, Kenneth, Chen, Guanjie, Nalls, Michael A., Simonsick, Eleanor M., Tarazona-Santos, Eduardo, Lima-Costa, Maria Fernanda, Adeyemo, Adebowale, Shriner, Daniel, Rotimi, Charles N.
Publicado 2021

Long-read sequencing resolves a complex structural variant in PRKN Parkinson’s disease

por Daida, Kensuke, Funayama, Manabu, Billingsley, Kimberley J, Malik, Laksh, Miano-Burkhardt, Abigail, Leonard, Hampton L., Makarious, Mary B., Iwaki, Hirotaka, Ding, Jinhui, Gibbs, J. Raphael, Ishiguro, Mayu, Yoshino, Hiroyo, Ogaki, Kotaro, Oyama, Genko, Nishioka, Kenya, Nonaka, Risa, Akamatsu, Wado, Blauwendraat, Cornelis, Hattori, Nobutaka
Publicado 2023

Identification and prediction of Parkinson’s disease subtypes and progression using machine learning in two cohorts

por Dadu, Anant, Satone, Vipul, Kaur, Rachneet, Hashemi, Sayed Hadi, Leonard, Hampton, Iwaki, Hirotaka, Makarious, Mary B., Billingsley, Kimberley J., Bandres‐Ciga, Sara, Sargent, Lana J., Noyce, Alastair J., Daneshmand, Ali, Blauwendraat, Cornelis, Marek, Ken, Scholz, Sonja W., Singleton, Andrew B., Nalls, Mike A., Campbell, Roy H., Faghri, Faraz
Publicado 2022

Multi-ancestry meta-analysis and fine-mapping in Alzheimer’s disease

por Lake, Julie, Warly Solsberg, Caroline, Kim, Jonggeol Jeffrey, Acosta-Uribe, Juliana, Makarious, Mary B., Li, Zizheng, Levine, Kristin, Heutink, Peter, Alvarado, Chelsea X., Vitale, Dan, Kang, Sarang, Gim, Jungsoo, Lee, Kun Ho, Pina-Escudero, Stefanie D., Ferrucci, Luigi, Singleton, Andrew B., Blauwendraat, Cornelis, Nalls, Mike A., Yokoyama, Jennifer S., Leonard, Hampton L.
Publicado 2023

Accelerating Medicines Partnership: Parkinson's Disease. Genetic Resource

por Iwaki, Hirotaka, Leonard, Hampton L., Makarious, Mary B., Bookman, Matt, Landin, Barry, Vismer, David, Casey, Bradford, Gibbs, J. Raphael, Hernandez, Dena G., Blauwendraat, Cornelis, Vitale, Daniel, Song, Yeajin, Kumar, Dinesh, Dalgard, Clifton L., Sadeghi, Mahdiar, Dong, Xianjun, Misquitta, Leonie, Scholz, Sonja W., Scherzer, Clemens R., Nalls, Mike A., Biswas, Shameek, Singleton, Andrew B.
Publicado 2021

Genome-wide case-only analysis of gene-gene interactions with known Parkinson’s disease risk variants reveals link between LRRK2 and SYT10

por Aleknonytė-Resch, Milda, Trinh, Joanne, Leonard, Hampton, Delcambre, Sylvie, Leitão, Elsa, Lai, Dongbing, Smajić, Semra, Orr-Urtreger, Avi, Thaler, Avner, Blauwendraat, Cornelis, Sharma, Arunabh, Makarious, Mary B., Kim, Jonggeol Jeff, Lake, Julie, Rahmati, Pegah, Freitag-Wolf, Sandra, Seibler, Philip, Foroud, Tatiana, Singleton, Andrew B., Grünewald, Anne, Kaiser, Frank, Klein, Christine, Krawczak, Michael, Dempfle, Astrid
Publicado 2023

Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)

por Towns, Clodagh, Richer, Madeleine, Jasaityte, Simona, Stafford, Eleanor J., Joubert, Julie, Antar, Tarek, Martinez-Carrasco, Alejandro, Makarious, Mary B., Casey, Bradford, Vitale, Dan, Levine, Kristin, Leonard, Hampton, Pantazis, Caroline B., Screven, Laurel A., Hernandez, Dena G., Wegel, Claire E., Solle, Justin, Nalls, Mike A., Blauwendraat, Cornelis, Singleton, Andrew B., Tan, Manuela M. X., Iwaki, Hirotaka, Morris, Huw R.
Publicado 2023

The Parkinson's Disease Genome‐Wide Association Study Locus Browser

por Grenn, Francis P., Kim, Jonggeol J., Makarious, Mary B., Iwaki, Hirotaka, Illarionova, Anastasia, Brolin, Kajsa, Kluss, Jillian H., Schumacher‐Schuh, Artur F., Leonard, Hampton, Faghri, Faraz, Billingsley, Kimberley, Krohn, Lynne, Hall, Ashley, Diez‐Fairen, Monica, Periñán, Maria Teresa, Foo, Jia Nee, Sandor, Cynthia, Webber, Caleb, Fiske, Brian K., Gibbs, J. Raphael, Nalls, Mike A., Singleton, Andrew B., Bandres‐Ciga, Sara, Reed, Xylena, Blauwendraat, Cornelis
Publicado 2020

Multi-modality machine learning predicting Parkinson’s disease

por Makarious, Mary B., Leonard, Hampton L., Vitale, Dan, Iwaki, Hirotaka, Sargent, Lana, Dadu, Anant, Violich, Ivo, Hutchins, Elizabeth, Saffo, David, Bandres-Ciga, Sara, Kim, Jonggeol Jeff, Song, Yeajin, Maleknia, Melina, Bookman, Matt, Nojopranoto, Willy, Campbell, Roy H., Hashemi, Sayed Hadi, Botia, Juan A., Carter, John F., Craig, David W., Van Keuren-Jensen, Kendall, Morris, Huw R., Hardy, John A., Blauwendraat, Cornelis, Singleton, Andrew B., Faghri, Faraz, Nalls, Mike A.
Publicado 2022

NeuroBooster Array: A Genome-Wide Genotyping Platform to Study Neurological Disorders Across Diverse Populations

por Bandres-Ciga, Sara, Faghri, Faraz, Majounie, Elisa, Koretsky, Mathew J, Kim, Jeffrey, Levine, Kristin S, Leonard, Hampton, Makarious, Mary B, Iwaki, Hirotaka, Crea, Peter Wild, Hernandez, Dena G, Arepalli, Sampath, Billingsley, Kimberley, Lohmann, Katja, Klein, Christine, Lubbe, Steven J, Jabbari, Edwin, Saffie-Awad, Paula, Narendra, Derek, Reyes-Palomares, Armando, Quinn, John P, Schulte, Claudia, Morris, Huw R, Traynor, Bryan J., Scholz, Sonja W., Houlden, Henry, Hardy, John, Dumanis, Sonya, Riley, Ekemini, Blauwendraat, Cornelis, Singleton, Andrew, Nalls, Mike, Jeff, Janina, Vitale, Dan
Publicado 2023

Investigation of Autosomal Genetic Sex Differences in Parkinson's Disease

por Blauwendraat, Cornelis, Iwaki, Hirotaka, Makarious, Mary B., Bandres‐Ciga, Sara, Leonard, Hampton L., Grenn, Francis P., Lake, Julie, Krohn, Lynne, Tan, Manuela, Kim, Jonggeol J., Gibbs, Jesse R., Hernandez, Dena G., Ruskey, Jennifer A., Pihlstrøm, Lasse, Toft, Mathias, van Hilten, Jacobus J., Marinus, Johan, Schulte, Claudia, Brockmann, Kathrin, Sharma, Manu, Siitonen, Ari, Majamaa, Kari, Eerola‐Rautio, Johanna, Tienari, Pentti J., Grosset, Donald G., Lesage, Suzanne, Corvol, Jean‐Christophe, Brice, Alexis, Wood, Nick, Hardy, John, Gan‐Or, Ziv, Heutink, Peter, Gasser, Thomas, Morris, Huw R., Noyce, Alastair J., Nalls, Mike A., Singleton, Andrew B.
Publicado 2021

Identification and single-base gene-editing functional validation of a cis-EPO variant as a genetic predictor for EPO-increasing therapies

por Harlow, Charli E., Gandawijaya, Josan, Bamford, Rosemary A., Martin, Emily-Rose, Wood, Andrew R., van der Most, Peter J., Tanaka, Toshiko, Leonard, Hampton L., Etheridge, Amy S., Innocenti, Federico, Beaumont, Robin N., Tyrrell, Jessica, Nalls, Mike A., Simonsick, Eleanor M., Garimella, Pranav S., Shiroma, Eric J., Verweij, Niek, van der Meer, Peter, Gansevoort, Ron T., Snieder, Harold, Gallins, Paul J., Jima, Dereje D., Wright, Fred, Zhou, Yi-hui, Ferrucci, Luigi, Bandinelli, Stefania, Hernandez, Dena G., van der Harst, Pim, Patel, Vickas V., Waterworth, Dawn M., Chu, Audrey Y., Oguro-Ando, Asami, Frayling, Timothy M.
Publicado 2022