Rapid high-throughput analysis of DNaseI hypersensitive sites using a modified Multiplex Ligation-dependent Probe Amplification approach

por Ohnesorg, Thomas, Eggers, Stefanie, Leonhard, Wouter N, Sinclair, Andrew H, White, Stefan J
Publicado 2009

Quantification of Cre-mediated recombination by a novel strategy reveals a stable extra-chromosomal deletion-circle in mice

por Leonhard, Wouter N, Roelfsema, Jeroen H, Lantinga-van Leeuwen, Irma S, Breuning, Martijn H, Peters, Dorien JM
Publicado 2008

Preclinical evaluation of tolvaptan and salsalate combination therapy in a Pkd1-mouse model

por Song, Xuewen, Leonhard, Wouter N., Kanhai, Anish A., Steinberg, Gregory R., Pei, York, Peters, Dorien J. M.
Publicado 2023

Renal cyst growth is attenuated by a combination treatment of tolvaptan and pioglitazone, while pioglitazone treatment alone is not effective

por Kanhai, Anish A., Bange, Hester, Verburg, Lotte, Dijkstra, Kyra L., Price, Leo S., Peters, Dorien J. M., Leonhard, Wouter N.
Publicado 2020

Salsalate, but not metformin or canagliflozin, slows kidney cyst growth in an adult-onset mouse model of polycystic kidney disease

por Leonhard, Wouter N., Song, Xuewen, Kanhai, Anish A., Iliuta, Ioan-Andrei, Bozovic, Andrea, Steinberg, Gregory R., Peters, Dorien J.M., Pei, York
Publicado 2019

Urine Fetuin-A is a biomarker of autosomal dominant polycystic kidney disease progression

por Piazzon, Nathalie, Bernet, Florian, Guihard, Linda, Leonhard, Wouter N, Urfer, Séverine, Firsov, Dmitri, Chehade, Hassib, Vogt, Bruno, Piergiovanni, Sophia, Peters, Dorien JM, Bonny, Olivier, Constam, Daniel B
Publicado 2015

Fluid shear stress-induced TGF-β/ALK5 signaling in renal epithelial cells is modulated by MEK1/2

por Kunnen, Steven J., Leonhard, Wouter N., Semeins, Cor, Hawinkels, Lukas J. A. C., Poelma, Christian, ten Dijke, Peter, Bakker, Astrid, Hierck, Beerend P., Peters, Dorien J. M.
Publicado 2017

Prioritization of novel ADPKD drug candidates from disease-stage specific gene expression profiles

por Malas, Tareq B., Leonhard, Wouter N., Bange, Hester, Granchi, Zoraide, Hettne, Kristina M., Van Westen, Gerard J.P., Price, Leo S., 't Hoen, Peter A.C., Peters, Dorien J.M.
Publicado 2019

High-Throughput Phenotypic Screening of Kinase Inhibitors to Identify Drug Targets for Polycystic Kidney Disease

por Booij, Tijmen H., Bange, Hester, Leonhard, Wouter N., Yan, Kuan, Fokkelman, Michiel, Kunnen, Steven J., Dauwerse, Johannes G., Qin, Yu, van de Water, Bob, van Westen, Gerard J. P., Peters, Dorien J. M., Price, Leo S.
Publicado 2017

In vitro 3D phenotypic drug screen identifies celastrol as an effective in vivo inhibitor of polycystic kidney disease

por Booij, Tijmen H, Leonhard, Wouter N, Bange, Hester, Yan, Kuan, Fokkelman, Michiel, Plugge, Anna J, Veraar, Kimberley A M, Dauwerse, Johannes G, van Westen, Gerard J P, van de Water, Bob, Price, Leo S, Peters, Dorien J M
Publicado 2019

Short salsalate administration affects cell proliferation, metabolism, and inflammation in polycystic kidney disease

por Kanhai, Anish A., Sánchez-López, Elena, Kuipers, Thomas B., van Klinken, Jan B., Dijkstra, Kyra L., van der Veen, Inge, Baelde, Hans J., Song, Xuewen, Pei, York, Mei, Hailiang, Leonhard, Wouter N., Mayboroda, Oleg A., Peters, Dorien J.M.
Publicado 2023