Real-time tracking of drug binding to influenza A M2 reveals a high energy barrier

por Tekwani Movellan, Kumar, Wegstroth, Melanie, Overkamp, Kerstin, Leonov, Andrei, Becker, Stefan, Andreas, Loren B.
Publicado 2023

Imidazole–Imidazole Hydrogen Bonding in the pH-Sensing Histidine Side Chains of Influenza A M2

por Movellan, Kumar Tekwani, Wegstroth, Melanie, Overkamp, Kerstin, Leonov, Andrei, Becker, Stefan, Andreas, Loren B.
Publicado 2020

Cys-Ph-TAHA: a lanthanide binding tag for RDC and PCS enhanced protein NMR

por Peters, Fabian, Maestre-Martinez, Mitcheell, Leonov, Andrei, Kovačič, Lidija, Becker, Stefan, Boelens, Rolf, Griesinger, Christian
Publicado 2011

Membrane-embedded TSPO: an NMR view

por Rivière, Gwladys, Jaipuria, Garima, Andreas, Loren B., Leonov, Andrei, Giller, Karin, Becker, Stefan, Zweckstetter, Markus
Publicado 2020

Lanthanide Tagging of Oligonucleotides to Nucleobase for Paramagnetic NMR

por Täubert, Sebastian, Zhang, Yong‐Hui, Martinez, Mitcheell Maestre, Siepel, Florian, Wöltjen, Edith, Leonov, Andrei, Griesinger, Christian
Publicado 2020

The oligomer modulator anle138b inhibits disease progression in a Parkinson mouse model even with treatment started after disease onset

por Levin, Johannes, Schmidt, Felix, Boehm, Cathrin, Prix, Catharina, Bötzel, Kai, Ryazanov, Sergey, Leonov, Andrei, Griesinger, Christian, Giese, Armin
Publicado 2014

Anle138b modulates α‐synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy

por Heras‐Garvin, Antonio, Weckbecker, Daniel, Ryazanov, Sergey, Leonov, Andrei, Griesinger, Christian, Giese, Armin, Wenning, Gregor K., Stefanova, Nadia
Publicado 2018

Cholesterol-mediated allosteric regulation of the mitochondrial translocator protein structure

por Jaipuria, Garima, Leonov, Andrei, Giller, Karin, Vasa, Suresh Kumar, Jaremko, Łukasz, Jaremko, Mariusz, Linser, Rasmus, Becker, Stefan, Zweckstetter, Markus
Publicado 2017

Anle138b Partly Ameliorates Motor Deficits Despite Failure of Neuroprotection in a Model of Advanced Multiple System Atrophy

por Fellner, Lisa, Kuzdas-Wood, Daniela, Levin, Johannes, Ryazanov, Sergey, Leonov, Andrei, Griesinger, Christian, Giese, Armin, Wenning, Gregor K., Stefanova, Nadia
Publicado 2016

Iron-mediated aggregation and toxicity in a novel neuronal cell culture model with inducible alpha-synuclein expression

por Bartels, Martin, Weckbecker, Daniel, Kuhn, Peer-Hendrik, Ryazanov, Sergey, Leonov, Andrei, Griesinger, Christian, Lichtenthaler, Stefan F., Bötzel, Kai, Giese, Armin
Publicado 2019

The small molecule inhibitor anle145c thermodynamically traps human islet amyloid peptide in the form of non-cytotoxic oligomers

por Saravanan, Manikam S., Ryazanov, Sergey, Leonov, Andrei, Nicolai, Janine, Praest, Patrique, Giese, Armin, Winter, Roland, Khemtemourian, Lucie, Griesinger, Christian, Killian, J. Antoinette
Publicado 2019

Function of the ribosomal E-site: a mutagenesis study

por Sergiev, Petr V., Lesnyak, Dmitry V., Kiparisov, Sergey V., Burakovsky, Dmitry E., Leonov, Andrei A., Bogdanov, Alexey A., Brimacombe, Richard, Dontsova, Olga A.
Publicado 2005

Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization

por Dominguez-Meijide, Antonio, Vasili, Eftychia, König, Annekatrin, Cima-Omori, Maria-Sol, Ibáñez de Opakua, Alain, Leonov, Andrei, Ryazanov, Sergey, Zweckstetter, Markus, Griesinger, Christian, Outeiro, Tiago F.
Publicado 2020

(11)C Radiolabeling of anle253b: a Putative PET Tracer for Parkinson's Disease That Binds to α‐Synuclein Fibrils in vitro and Crosses the Blood‐Brain Barrier

por Maurer, Andreas, Leonov, Andrei, Ryazanov, Sergey, Herfert, Kristina, Kuebler, Laura, Buss, Sabrina, Schmidt, Felix, Weckbecker, Daniel, Linder, Ruth, Bender, Dirk, Giese, Armin, Pichler, Bernd J., Griesinger, Christian
Publicado 2020

Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson’s disease model

por Wegrzynowicz, Michal, Bar-On, Dana, Calo’, Laura, Anichtchik, Oleg, Iovino, Mariangela, Xia, Jing, Ryazanov, Sergey, Leonov, Andrei, Giese, Armin, Dalley, Jeffrey W., Griesinger, Christian, Ashery, Uri, Spillantini, Maria Grazia
Publicado 2019

Targeting α-synuclein by PD03 AFFITOPE® and Anle138b rescues neurodegenerative pathology in a model of multiple system atrophy: clinical relevance

por Lemos, Miguel, Venezia, Serena, Refolo, Violetta, Heras-Garvin, Antonio, Schmidhuber, Sabine, Giese, Armin, Leonov, Andrei, Ryazanov, Sergey, Griesinger, Christian, Galabova, Gergana, Staffler, Guenther, Wenning, Gregor Karl, Stefanova, Nadia
Publicado 2020

[(11)C]MODAG-001—towards a PET tracer targeting α-synuclein aggregates

por Kuebler, Laura, Buss, Sabrina, Leonov, Andrei, Ryazanov, Sergey, Schmidt, Felix, Maurer, Andreas, Weckbecker, Daniel, Landau, Anne M., Lillethorup, Thea P., Bleher, Daniel, Saw, Ran Sing, Pichler, Bernd J., Griesinger, Christian, Giese, Armin, Herfert, Kristina
Publicado 2020

The clinical drug candidate anle138b binds in a cavity of lipidic α-synuclein fibrils

por Antonschmidt, Leif, Matthes, Dirk, Dervişoğlu, Rıza, Frieg, Benedikt, Dienemann, Christian, Leonov, Andrei, Nimerovsky, Evgeny, Sant, Vrinda, Ryazanov, Sergey, Giese, Armin, Schröder, Gunnar F., Becker, Stefan, de Groot, Bert L., Griesinger, Christian, Andreas, Loren B.
Publicado 2022

Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, dou...

por Levin, Johannes, Sing, Nand, Melbourne, Sue, Morgan, Amber, Mariner, Carla, Spillantini, Maria Grazia, Wegrzynowicz, Michal, Dalley, Jeffrey W., Langer, Simon, Ryazanov, Sergey, Leonov, Andrei, Griesinger, Christian, Schmidt, Felix, Weckbecker, Daniel, Prager, Kai, Matthias, Torsten, Giese, Armin
Publicado 2022

Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies

por Wagner, Jens, Krauss, Sybille, Shi, Song, Ryazanov, Sergey, Steffen, Julia, Miklitz, Carolin, Leonov, Andrei, Kleinknecht, Alexander, Göricke, Bettina, Weishaupt, Jochen H., Weckbecker, Daniel, Reiner, Anne M., Zinth, Wolfgang, Levin, Johannes, Ehninger, Dan, Remy, Stefan, Kretzschmar, Hans A., Griesinger, Christian, Giese, Armin, Fuhrmann, Martin
Publicado 2015