Unravelling the role of transient redox partner complexes in P450 electron transfer mechanics

por Hargrove, Tatiana Y., Lamb, David C., Smith, Jarrod A., Wawrzak, Zdzislaw, Kelly, Steven L., Lepesheva, Galina I.
Publicado 2022

Processive kinetics in the three-step lanosterol 14α-demethylation reaction catalyzed by human cytochrome P450 51A1

por McCarty, Kevin D., Sullivan, Molly E., Tateishi, Yasuhiro, Hargrove, Tatiana Y., Lepesheva, Galina I., Guengerich, F. Peter
Publicado 2023

Structural Basis for Rational Design of Inhibitors Targeting Trypanosoma cruzi Sterol 14α-Demethylase: Two Regions of the Enzyme Molecule Potentiate Its Inhibition

por Friggeri, Laura, Hargrove, Tatiana Y., Rachakonda, Girish, Williams, Amanda D., Wawrzak, Zdzislaw, Di Santo, Roberto, De Vita, Daniela, Waterman, Michael R., Tortorella, Silvano, Villalta, Fernando, Lepesheva, Galina I.
Publicado 2014

Concerning P450 Evolution: Structural Analyses Support Bacterial Origin of Sterol 14α-Demethylases

por Lamb, David C, Hargrove, Tatiana Y, Zhao, Bin, Wawrzak, Zdzislaw, Goldstone, Jared V, Nes, William David, Kelly, Steven L, Waterman, Michael R, Stegeman, John J, Lepesheva, Galina I
Publicado 2020

Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana

por Mwenechanya, Roy, Kovářová, Julie, Dickens, Nicholas J., Mudaliar, Manikhandan, Herzyk, Pawel, Vincent, Isabel M., Weidt, Stefan K., Burgess, Karl E., Burchmore, Richard J. S., Pountain, Andrew W., Smith, Terry K., Creek, Darren J., Kim, Dong-Hyun, Lepesheva, Galina I., Barrett, Michael P.
Publicado 2017