Colorectal Cancer Chemoprevention: A Dream Coming True?

por Lepore Signorile, Martina, Grossi, Valentina, Fasano, Candida, Simone, Cristiano
Publicado 2023

FOXO3a from the Nucleus to the Mitochondria: A Round Trip in Cellular Stress Response

por Fasano, Candida, Disciglio, Vittoria, Bertora, Stefania, Lepore Signorile, Martina, Simone, Cristiano
Publicado 2019

Chasing the FOXO3: Insights into Its New Mitochondrial Lair in Colorectal Cancer Landscape

por Grossi, Valentina, Fasano, Candida, Celestini, Valentina, Lepore Signorile, Martina, Sanese, Paola, Simone, Cristiano
Publicado 2019

From Genetics to Histomolecular Characterization: An Insight into Colorectal Carcinogenesis in Lynch Syndrome

por Lepore Signorile, Martina, Disciglio, Vittoria, Di Carlo, Gabriella, Pisani, Antonio, Simone, Cristiano, Ingravallo, Giuseppe
Publicado 2021

Identifying novel SMYD3 interactors on the trail of cancer hallmarks

por Fasano, Candida, Lepore Signorile, Martina, De Marco, Katia, Forte, Giovanna, Sanese, Paola, Grossi, Valentina, Simone, Cristiano
Publicado 2022

APC Splicing Mutations Leading to In-Frame Exon 12 or Exon 13 Skipping Are Rare Events in FAP Pathogenesis and Define the Clinical Outcome

por Disciglio, Vittoria, Forte, Giovanna, Fasano, Candida, Sanese, Paola, Lepore Signorile, Martina, De Marco, Katia, Grossi, Valentina, Cariola, Filomena, Simone, Cristiano
Publicado 2021

The chromatin remodeling factors EP300 and TRRAP are novel SMYD3 interactors involved in the emerging ‘nonmutational epigenetic reprogramming’ cancer hallmark

por Fasano, Candida, Lepore Signorile, Martina, Di Nicola, Elisabetta, Pantaleo, Antonino, Forte, Giovanna, De Marco, Katia, Sanese, Paola, Disciglio, Vittoria, Grossi, Valentina, Simone, Cristiano
Publicado 2023

Uncoupling p38α nuclear and cytoplasmic functions and identification of two p38α phosphorylation sites on β-catenin: implications for the Wnt signaling pathway in CRC models

por Lepore Signorile, Martina, Fasano, Candida, Forte, Giovanna, De Marco, Katia, Sanese, Paola, Disciglio, Vittoria, Di Nicola, Elisabetta, Pantaleo, Antonino, Simone, Cristiano, Grossi, Valentina
Publicado 2023

Gastric polyposis and desmoid tumours as a new familial adenomatous polyposis clinical variant associated with APC mutation at the extreme 3′-end

por Disciglio, Vittoria, Fasano, Candida, Cariola, Filomena, Forte, Giovanna, Grossi, Valentina, Sanese, Paola, Lepore Signorile, Martina, Resta, Nicoletta, Lotesoriere, Claudio, Stella, Alessandro, Lolli, Ivan, Simone, Cristiano
Publicado 2020

Identification and Somatic Characterization of the Germline PTEN Promoter Variant rs34149102 in a Family with Gastrointestinal and Breast Tumors

por Disciglio, Vittoria, Sanese, Paola, Fasano, Candida, Lotesoriere, Claudio, Valentini, Anna Maria, Forte, Giovanna, Lepore Signorile, Martina, De Marco, Katia, Grossi, Valentina, Lolli, Ivan, Cariola, Filomena, Simone, Cristiano
Publicado 2022

SMYD3 Modulates the HGF/MET Signaling Pathway in Gastric Cancer

por De Marco, Katia, Lepore Signorile, Martina, Di Nicola, Elisabetta, Sanese, Paola, Fasano, Candida, Forte, Giovanna, Disciglio, Vittoria, Pantaleo, Antonino, Varchi, Greta, Del Rio, Alberto, Grossi, Valentina, Simone, Cristiano
Publicado 2023

c-MYC Protein Stability Is Sustained by MAPKs in Colorectal Cancer

por Lepore Signorile, Martina, Grossi, Valentina, Fasano, Candida, Forte, Giovanna, Disciglio, Vittoria, Sanese, Paola, De Marco, Katia, La Rocca, Francesca, Armentano, Raffaele, Valentini, Anna Maria, Giannelli, Gianluigi, Simone, Cristiano
Publicado 2022

The longevity SNP rs2802292 uncovered: HSF1 activates stress-dependent expression of FOXO3 through an intronic enhancer

por Grossi, Valentina, Forte, Giovanna, Sanese, Paola, Peserico, Alessia, Tezil, Tugsan, Lepore Signorile, Martina, Fasano, Candida, Lovaglio, Rosaura, Bagnulo, Rosanna, Loconte, Daria C, Susca, Francesco C, Resta, Nicoletta, Simone, Cristiano
Publicado 2018

SMYD3 Modulates AMPK-mTOR Signaling Balance in Cancer Cell Response to DNA Damage

por Lepore Signorile, Martina, Sanese, Paola, Di Nicola, Elisabetta, Fasano, Candida, Forte, Giovanna, De Marco, Katia, Disciglio, Vittoria, Latrofa, Marialaura, Pantaleo, Antonino, Varchi, Greta, Del Rio, Alberto, Grossi, Valentina, Simone, Cristiano
Publicado 2023

Coinheritance of germline mutations in APC and MUTYH genes defines the clinical outcome of adenomatous polyposis syndromes

por Forte, Giovanna, Cariola, Filomena, Buonadonna, Antonia Lucia, Guglielmi, Anna Filomena, Manghisi, Andrea, De Marco, Katia, Grossi, Valentina, Fasano, Candida, Lepore Signorile, Martina, Sanese, Paola, Bagnulo, Rosanna, Resta, Nicoletta, Disciglio, Vittoria, Simone, Cristiano
Publicado 2022

Tumor Testing and Genetic Analysis to Identify Lynch Syndrome Patients in an Italian Colorectal Cancer Cohort

por Pantaleo, Antonino, Forte, Giovanna, Cariola, Filomena, Valentini, Anna Maria, Fasano, Candida, Sanese, Paola, Grossi, Valentina, Buonadonna, Antonia Lucia, De Marco, Katia, Lepore Signorile, Martina, Guglielmi, Anna Filomena, Manghisi, Andrea, Gigante, Gianluigi, Armentano, Raffaele, Disciglio, Vittoria, Simone, Cristiano
Publicado 2023

Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy

por Celestini, Valentina, Tezil, Tugsan, Russo, Luciana, Fasano, Candida, Sanese, Paola, Forte, Giovanna, Peserico, Alessia, Lepore Signorile, Martina, Longo, Giovanna, De Rasmo, Domenico, Signorile, Anna, Gadaleta, Raffaella Maria, Scialpi, Natasha, Terao, Mineko, Garattini, Enrico, Cocco, Tiziana, Villani, Gaetano, Moschetta, Antonio, Grossi, Valentina, Simone, Cristiano
Publicado 2018

Pharmacological targeting of the novel β-catenin chromatin-associated kinase p38α in colorectal cancer stem cell tumorspheres and organoids

por Lepore Signorile, Martina, Grossi, Valentina, Di Franco, Simone, Forte, Giovanna, Disciglio, Vittoria, Fasano, Candida, Sanese, Paola, De Marco, Katia, Susca, Francesco Claudio, Mangiapane, Laura Rosa, Nicotra, Annalisa, Di Carlo, Gabriella, Dituri, Francesco, Giannelli, Gianluigi, Ingravallo, Giuseppe, Canettieri, Gianluca, Stassi, Giorgio, Simone, Cristiano
Publicado 2021

Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase

por Talibov, Vladimir O., Fabini, Edoardo, FitzGerald, Edward A., Tedesco, Daniele, Cederfeldt, Daniela, Talu, Martin J., Rachman, Moira M., Mihalic, Filip, Manoni, Elisabetta, Naldi, Marina, Sanese, Paola, Forte, Giovanna, Lepore Signorile, Martina, Barril, Xavier, Simone, Cristiano, Bartolini, Manuela, Dobritzsch, Doreen, Del Rio, Alberto, Danielson, U. Helena
Publicado 2021

Targeting SMYD3 to Sensitize Homologous Recombination-Proficient Tumors to PARP-Mediated Synthetic Lethality

por Sanese, Paola, Fasano, Candida, Buscemi, Giacomo, Bottino, Cinzia, Corbetta, Silvia, Fabini, Edoardo, Silvestri, Valentina, Valentini, Virginia, Disciglio, Vittoria, Forte, Giovanna, Lepore Signorile, Martina, De Marco, Katia, Bertora, Stefania, Grossi, Valentina, Guven, Ummu, Porta, Natale, Di Maio, Valeria, Manoni, Elisabetta, Giannelli, Gianluigi, Bartolini, Manuela, Del Rio, Alberto, Caretti, Giuseppina, Ottini, Laura, Simone, Cristiano
Publicado 2020