Enzymatic activity and immunoreactivity of Aca s 4, an alpha-amylase allergen from the storage mite Acarus siro

por Pytelková, Jana, Lepšík, Martin, Šanda, Miloslav, Talacko, Pavel, Marešová, Lucie, Mareš, Michael
Publicado 2012

Aurora kinase inhibitors: Progress towards the clinic

por Kollareddy, Madhu, Zheleva, Daniella, Dzubak, Petr, Brahmkshatriya, Pathik Subhashchandra, Lepsik, Martin, Hajduch, Marian
Publicado 2012

Structural determinants for subnanomolar inhibition of the secreted aspartic protease Sapp1p from Candida parapsilosis

por Dostál, Jiří, Brynda, Jiří, Vaňková, Lucie, Zia, Syeda Rehana, Pichová, Iva, Heidingsfeld, Olga, Lepšík, Martin
Publicado 2021

Substrate binding and specificity of rhomboid intramembrane protease revealed by substrate–peptide complex structures

por Zoll, Sebastian, Stanchev, Stancho, Began, Jakub, Škerle, Jan, Lepšík, Martin, Peclinovská, Lucie, Majer, Pavel, Strisovsky, Kvido
Publicado 2014

Myristoylation drives dimerization of matrix protein from mouse mammary tumor virus

por Doležal, Michal, Zábranský, Aleš, Dostál, Jiří, Vaněk, Ondřej, Brynda, Jiří, Lepšík, Martin, Hadravová, Romana, Pichová, Iva
Publicado 2016

Superior Performance of the SQM/COSMO Scoring Functions in Native Pose Recognition of Diverse Protein–Ligand Complexes in Cognate Docking

por Ajani, Haresh, Pecina, Adam, Eyrilmez, Saltuk M., Fanfrlík, Jindřich, Haldar, Susanta, Řezáč, Jan, Hobza, Pavel, Lepšík, Martin
Publicado 2017

Helquat dyes targeting G-quadruplexes as a new class of anti-HIV-1 inhibitors

por Pávová, Marcela, Reyes-Gutiérrez, Paul Eduardo, Kozák, Jaroslav, Dobiaš, Juraj, Yurenko, Yevgen, Lepšík, Martin, Teplý, Filip, Weber, Jan
Publicado 2023

The Role of Cysteine Residues in Catalysis of Phosphoenolpyruvate Carboxykinase from Mycobacterium tuberculosis

por Machová, Iva, Hubálek, Martin, Lepšík, Martin, Bednárová, Lucie, Pazderková, Markéta, Kopecký, Vladimír, Snášel, Jan, Dostál, Jiří, Pichová, Iva
Publicado 2017

Structural characterization of CAS SH3 domain selectivity and regulation reveals new CAS interaction partners

por Gemperle, Jakub, Hexnerová, Rozálie, Lepšík, Martin, Tesina, Petr, Dibus, Michal, Novotný, Marian, Brábek, Jan, Veverka, Václav, Rosel, Daniel
Publicado 2017

Human insulin analogues modified at the B26 site reveal a hormone conformation that is undetected in the receptor complex

por Žáková, Lenka, Kletvíková, Emília, Lepšík, Martin, Collinsová, Michaela, Watson, Christopher J., Turkenburg, Johan P., Jiráček, Jiří, Brzozowski, Andrzej M.
Publicado 2014

In Vitro Evolution Reveals Noncationic Protein–RNA Interaction Mediated by Metal Ions

por Giacobelli, Valerio G, Fujishima, Kosuke, Lepšík, Martin, Tretyachenko, Vyacheslav, Kadavá, Tereza, Makarov, Mikhail, Bednárová, Lucie, Novák, Petr, Hlouchová, Klára
Publicado 2022

Carborane-Based Carbonic Anhydrase Inhibitors: Insight into CAII/CAIX Specificity from a High-Resolution Crystal Structure, Modeling, and Quantum Chemical Calculations

por Mader, Pavel, Pecina, Adam, Cígler, Petr, Lepšík, Martin, Šícha, Václav, Hobza, Pavel, Grüner, Bohumír, Fanfrlík, Jindřich, Brynda, Jiří, Řezáčová, Pavlína
Publicado 2014

Modulation of HIV-1 Gag NC/p1 cleavage efficiency affects protease inhibitor resistance and viral replicative capacity

por van Maarseveen, Noortje M, Andersson, Dan, Lepšík, Martin, Fun, Axel, Schipper, Pauline J, de Jong, Dorien, Boucher, Charles AB, Nijhuis, Monique
Publicado 2012

Powerful Avidity with a Limited Valency for Virus-Attachment Blockers on DC-SIGN: Combining Chelation and Statistical Rebinding with Structural Plasticity of the Receptor

por Porkolab, Vanessa, Lepšík, Martin, Ordanini, Stefania, St John, Alexander, Le Roy, Aline, Thépaut, Michel, Paci, Emanuele, Ebel, Christine, Bernardi, Anna, Fieschi, Franck
Publicado 2023

Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes

por Benýšek, Jakub, Buša, Michal, Rubešová, Petra, Fanfrlík, Jindřich, Lepšík, Martin, Brynda, Jiří, Matoušková, Zuzana, Bartz, Ulrike, Horn, Martin, Gütschow, Michael, Mareš, Michael
Publicado 2022

Azanitrile Inhibitors of the SmCB1 Protease Target Are Lethal to Schistosoma mansoni: Structural and Mechanistic Insights into Chemotype Reactivity

por Jílková, Adéla, Horn, Martin, Fanfrlík, Jindřich, Küppers, Jim, Pachl, Petr, Řezáčová, Pavlína, Lepšík, Martin, Fajtová, Pavla, Rubešová, Petra, Chanová, Marta, Caffrey, Conor R., Gütschow, Michael, Mareš, Michael
Publicado 2020

Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors

por Jílková, Adéla, Rubešová, Petra, Fanfrlík, Jindřich, Fajtová, Pavla, Řezáčová, Pavlína, Brynda, Jiří, Lepšík, Martin, Mertlíková-Kaiserová, Helena, Emal, Cory D., Renslo, Adam R., Roush, William R., Horn, Martin, Caffrey, Conor R., Mareš, Michael
Publicado 2020

General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases

por Tichá, Anežka, Stanchev, Stancho, Vinothkumar, Kutti R., Mikles, David C., Pachl, Petr, Began, Jakub, Škerle, Jan, Švehlová, Kateřina, Nguyen, Minh T.N., Verhelst, Steven H.L., Johnson, Darren C., Bachovchin, Daniel A., Lepšík, Martin, Majer, Pavel, Strisovsky, Kvido
Publicado 2017

Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor- and hormone-specific responses

por Macháčková, Kateřina, Mlčochová, Květoslava, Potalitsyn, Pavlo, Hanková, Kateřina, Socha, Ondřej, Buděšínský, Miloš, Muždalo, Anja, Lepšík, Martin, Černeková, Michaela, Radosavljević, Jelena, Fábry, Milan, Mitrová, Katarína, Chrudinová, Martina, Lin, Jingjing, Yurenko, Yevgen, Hobza, Pavel, Selicharová, Irena, Žáková, Lenka, Jiráček, Jiří
Publicado 2019