Synthetic studies towards bottromycin

por Ackermann, Stefanie, Lerchen, Hans-Georg, Häbich, Dieter, Ullrich, Angelika, Kazmaier, Uli
Publicado 2012

Antibody–drug conjugates harboring a kinesin spindle protein inhibitor with immunostimulatory properties

por Sommer, Anette, Berndt, Sandra, Lerchen, Hans-Georg, Forveille, Sabrina, Sauvat, Allan, Mumberg, Dominik, Kroemer, Guido, Kepp, Oliver
Publicado 2022

A Small Molecule–Drug Conjugate (SMDC) Consisting of a Modified Camptothecin Payload Linked to an α(V)ß(3) Binder for the Treatment of Multiple Cancer Types

por Lerchen, Hans-Georg, Stelte-Ludwig, Beatrix, Kopitz, Charlotte, Heroult, Melanie, Zubov, Dmitry, Willuda, Joerg, Schlange, Thomas, Kahnert, Antje, Wong, Harvey, Izumi, Raquel, Hamdy, Ahmed
Publicado 2022

Discovery of VIP236, an αvβ3-Targeted Small-Molecule–Drug Conjugate with Neutrophil Elastase-Mediated Activation of 7-Ethyl Camptothecin Payload for Treatment of Solid Tumors

por Lerchen, Hans-Georg, Stelte-Ludwig, Beatrix, Heroult, Melanie, Zubov, Dmitry, Gericke, Kersten Matthias, Wong, Harvey, Frigault, Melanie M., Johnson, Amy J., Izumi, Raquel, Hamdy, Ahmed
Publicado 2023

Neutrophil Elastase Promotes Linker Cleavage and Paclitaxel Release from an Integrin‐Targeted Conjugate

por Raposo Moreira Dias, André, Pina, Arianna, Dean, Amelia, Lerchen, Hans‐Georg, Caruso, Michele, Gasparri, Fabio, Fraietta, Ivan, Troiani, Sonia, Arosio, Daniela, Belvisi, Laura, Pignataro, Luca, Dal Corso, Alberto, Gennari, Cesare
Publicado 2018

IL3RA-Targeting Antibody–Drug Conjugate BAY-943 with a Kinesin Spindle Protein Inhibitor Payload Shows Efficacy in Preclinical Models of Hematologic Malignancies

por Kirchhoff, Dennis, Stelte-Ludwig, Beatrix, Lerchen, Hans-Georg, Wengner, Antje Margret, von Ahsen, Oliver, Buchmann, Pascale, Märsch, Stephan, Mahlert, Christoph, Greven, Simone, Dietz, Lisa, Erkelenz, Michael, Zierz, Ruprecht, Johanssen, Sandra, Mumberg, Dominik, Sommer, Anette
Publicado 2020