Characterization of the Vitrocell® 24/48 in vitro aerosol exposure system using mainstream cigarette smoke

por Majeed, Shoaib, Frentzel, Stefan, Wagner, Sandra, Kuehn, Diana, Leroy, Patrice, Guy, Philippe A, Knorr, Arno, Hoeng, Julia, Peitsch, Manuel C
Publicado 2014

Alterations in Serum Polyunsaturated Fatty Acids and Eicosanoids in Patients with Mild to Moderate Chronic Obstructive Pulmonary Disease (COPD)

por Titz, Bjoern, Luettich, Karsta, Leroy, Patrice, Boue, Stephanie, Vuillaume, Gregory, Vihervaara, Terhi, Ekroos, Kim, Martin, Florian, Peitsch, Manuel C., Hoeng, Julia
Publicado 2016

Physiological and biological characterization of smokers with and without COPD

por Chaudhary, Nveed, Luettich, Karsta, Peck, Michael J., Pierri, Elena, Felber-Medlin, Loyse, Vuillaume, Gregory, Leroy, Patrice, Hoeng, Julia, Peitsch, Manuel C.
Publicado 2018

Mechanistic Evaluation of the Impact of Smoking and Chronic Obstructive Pulmonary Disease on the Nasal Epithelium

por Talikka, Marja, Martin, Florian, Sewer, Alain, Vuillaume, Grégory, Leroy, Patrice, Luettich, Karsta, Chaudhary, Nveed, Peck, Michael J, Peitsch, Manuel C, Hoeng, Julia
Publicado 2017

Impact Assessment of Cigarette Smoke Exposure on Organotypic Bronchial Epithelial Tissue Cultures: A Comparison of Mono-Culture and Coculture Model Containing Fibroblasts

por Iskandar, Anita R., Xiang, Yang, Frentzel, Stefan, Talikka, Marja, Leroy, Patrice, Kuehn, Diana, Guedj, Emmanuel, Martin, Florian, Mathis, Carole, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia
Publicado 2015

Reduced Chronic Toxicity and Carcinogenicity in A/J Mice in Response to Life-Time Exposure to Aerosol From a Heated Tobacco Product Compared With Cigarette Smoke

por Wong, Ee Tsin, Luettich, Karsta, Krishnan, Subash, Wong, Sin Kei, Lim, Wei Ting, Yeo, Demetrius, Büttner, Ansgar, Leroy, Patrice, Vuillaume, Grégory, Boué, Stéphanie, Hoeng, Julia, Vanscheeuwijck, Patrick, Peitsch, Manuel C
Publicado 2020

A framework for in vitro systems toxicology assessment of e-liquids

por Iskandar, Anita R., Gonzalez-Suarez, Ignacio, Majeed, Shoaib, Marescotti, Diego, Sewer, Alain, Xiang, Yang, Leroy, Patrice, Guedj, Emmanuel, Mathis, Carole, Schaller, Jean-Pierre, Vanscheeuwijck, Patrick, Frentzel, Stefan, Martin, Florian, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia
Publicado 2016

Comparative effects of a candidate modified-risk tobacco product Aerosol and cigarette smoke on human organotypic small airway cultures: a systems toxicology approach

por Iskandar, Anita R., Martinez, Yannick, Martin, Florian, Schlage, Walter K., Leroy, Patrice, Sewer, Alain, Torres, Laura Ortega, Majeed, Shoaib, Merg, Celine, Trivedi, Keyur, Guedj, Emmanuel, Frentzel, Stefan, Mathis, Carole, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia
Publicado 2017

Respiratory Effects of Exposure to Aerosol From the Candidate Modified-Risk Tobacco Product THS 2.2 in an 18-Month Systems Toxicology Study With A/J Mice

por Titz, Bjoern, Sewer, Alain, Luettich, Karsta, Wong, Ee Tsin, Guedj, Emmanuel, Nury, Catherine, Schneider, Thomas, Xiang, Yang, Trivedi, Keyur, Vuillaume, Grégory, Leroy, Patrice, Büttner, Ansgar, Martin, Florian, Ivanov, Nikolai V, Vanscheeuwijck, Patrick, Hoeng, Julia, Peitsch, Manuel C
Publicado 2020

Comparing the preclinical risk profile of inhalable candidate and potential candidate modified risk tobacco products: A bridging use case

por Schlage, Walter K., Titz, Bjoern, Iskandar, Anita, Poussin, Carine, Van der Toorn, Marco, Wong, Ee Tsin, Pratte, Pascal, Maeder, Serge, Schaller, Jean-Pierre, Pospisil, Pavel, Boue, Stephanie, Vuillaume, Grégory, Leroy, Patrice, Martin, Florian, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia
Publicado 2020

Impact of whole‐body versus nose‐only inhalation exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2‐month cigarette smoke exposure study in the ApoE(−/−...

por Kogel, Ulrike, Wong, Ee Tsin, Szostak, Justyna, Tan, Wei Teck, Lucci, Francesco, Leroy, Patrice, Titz, Bjoern, Xiang, Yang, Low, Tiffany, Wong, Sin Kei, Guedj, Emmanuel, Ivanov, Nikolai V., Schlage, Walter K., Peitsch, Manuel C., Kuczaj, Arkadiusz, Vanscheeuwijck, Patrick, Hoeng, Julia
Publicado 2021

An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe(−/−) Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Produ...

por Phillips, Blaine, Veljkovic, Emilija, Boué, Stéphanie, Schlage, Walter K., Vuillaume, Gregory, Martin, Florian, Titz, Bjoern, Leroy, Patrice, Buettner, Ansgar, Elamin, Ashraf, Oviedo, Alberto, Cabanski, Maciej, De León, Héctor, Guedj, Emmanuel, Schneider, Thomas, Talikka, Marja, Ivanov, Nikolai V., Vanscheeuwijck, Patrick, Peitsch, Manuel C., Hoeng, Julia
Publicado 2016

A lower impact of an acute exposure to electronic cigarette aerosols than to cigarette smoke in human organotypic buccal and small airway cultures was demonstrated using systems to...

por Iskandar, Anita R., Zanetti, Filippo, Kondylis, Athanasios, Martin, Florian, Leroy, Patrice, Majeed, Shoaib, Steiner, Sandro, Xiang, Yang, Ortega Torres, Laura, Trivedi, Keyur, Guedj, Emmanuel, Merg, Celine, Frentzel, Stefan, Ivanov, Nikolai V., Doshi, Utkarsh, Lee, Kyeonghee Monica, McKinney, Willie J., Peitsch, Manuel C., Hoeng, Julia
Publicado 2019

Systems toxicology assessment of a representative e-liquid formulation using human primary bronchial epithelial cells

por Marescotti, Diego, Mathis, Carole, Belcastro, Vincenzo, Leroy, Patrice, Acali, Stefano, Martin, Florian, Dulize, Rémi, Bornand, David, Peric, Dariusz, Guedj, Emmanuel, Ortega Torres, Laura, Biasioli, Matteo, Fuhrimann, Matthieu, Fernandes, Estela, Frauendorfer, Felix, Gonzalez Suarez, Ignacio, Sciuscio, Davide, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia
Publicado 2019

An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe(−/−) Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Produ...

por Phillips, Blaine, Veljkovic, Emilija, Boué, Stéphanie, Schlage, Walter K., Vuillaume, Gregory, Martin, Florian, Titz, Bjoern, Leroy, Patrice, Buettner, Ansgar, Elamin, Ashraf, Oviedo, Alberto, Cabanski, Maciej, De León, Héctor, Guedj, Emmanuel, Schneider, Thomas, Talikka, Marja, Ivanov, Nikolai V., Vanscheeuwijck, Patrick, Peitsch, Manuel C., Hoeng, Julia
Publicado 2016

Evaluation of toxicity of aerosols from flavored e-liquids in Sprague–Dawley rats in a 90-day OECD inhalation study, complemented by transcriptomics analysis

por Ho, Jenny, Sciuscio, Davide, Kogel, Ulrike, Titz, Bjoern, Leroy, Patrice, Vuillaume, Gregory, Talikka, Marja, Martin, Elyette, Pospisil, Pavel, Lebrun, Stefan, Xia, Wenhao, Lee, Tom, Chng, Yun Xuan, Phillips, Blaine W., Veljkovic, Emilija, Guedj, Emmanuel, Xiang, Yang, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia, Vanscheeuwijck, Patrick
Publicado 2020

Assessment of inhalation toxicity of cigarette smoke and aerosols from flavor mixtures: 5‐week study in A/J mice

por Wong, Ee Tsin, Luettich, Karsta, Cammack, Lydia, Chua, Chin Suan, Sciuscio, David, Merg, Celine, Corciulo, Maica, Piault, Romain, Ashutosh, Kumar, Smith, Cameron, Leroy, Patrice, Moine, Fabian, Glabasnia, Anneke, Diana, Pierrick, Chia, Cecilia, Tung, Ching Keong, Ivanov, Nikolai, Hoeng, Julia, Peitsch, Manuel, Lee, Kyeonghee Monica, Vanscheeuwijck, Patrick
Publicado 2022

Effects of Cigarette Smoke, Cessation, and Switching to Two Heat-Not-Burn Tobacco Products on Lung Lipid Metabolism in C57BL/6 and Apoe(−/−) Mice—An Integrative Systems Toxicology...

por Titz, Bjoern, Boué, Stéphanie, Phillips, Blaine, Talikka, Marja, Vihervaara, Terhi, Schneider, Thomas, Nury, Catherine, Elamin, Ashraf, Guedj, Emmanuel, Peck, Michael J., Schlage, Walter K., Cabanski, Maciej, Leroy, Patrice, Vuillaume, Gregory, Martin, Florian, Ivanov, Nikolai V., Veljkovic, Emilija, Ekroos, Kim, Laaksonen, Reijo, Vanscheeuwijck, Patrick, Peitsch, Manuel C., Hoeng, Julia
Publicado 2016

Multi-omics systems toxicology study of mouse lung assessing the effects of aerosols from two heat-not-burn tobacco products and cigarette smoke

por Titz, Bjoern, Szostak, Justyna, Sewer, Alain, Phillips, Blaine, Nury, Catherine, Schneider, Thomas, Dijon, Sophie, Lavrynenko, Oksana, Elamin, Ashraf, Guedj, Emmanuel, Tsin Wong, Ee, Lebrun, Stefan, Vuillaume, Grégory, Kondylis, Athanasios, Gubian, Sylvain, Cano, Stephane, Leroy, Patrice, Keppler, Brian, Ivanov, Nikolai V., Vanscheeuwijck, Patrick, Martin, Florian, Peitsch, Manuel C., Hoeng, Julia
Publicado 2020

E-vapor aerosols do not compromise bone integrity relative to cigarette smoke after 6-month inhalation in an ApoE(–/–) mouse model

por Reumann, Marie K., Schaefer, Jenny, Titz, Bjoern, Aspera-Werz, Romina H., Wong, Ee Tsin, Szostak, Justyna, Häussling, Victor, Ehnert, Sabrina, Leroy, Patrice, Tan, Wei Teck, Kuczaj, Arkadiusz, Audretsch, Christof, Springer, Fabian, Badke, Andreas, Augat, Peter, Quentanilla-Fend, Leticia, Martella, Manuela, Lee, K. Monica, Peitsch, Manuel C., Hoeng, Julia, Nussler, Andreas K.
Publicado 2020