Computational Modeling and Reverse Engineering to Reveal Dominant Regulatory Interactions Controlling Osteochondral Differentiation: Potential for Regenerative Medicine

por Lesage, Raphaelle, Kerkhofs, Johan, Geris, Liesbet
Publicado 2018

Mapping the use of computational modelling and simulation in clinics: A survey

por Lesage, Raphaëlle, Van Oudheusden, Michiel, Schievano, Silvia, Van Hoyweghen, Ine, Geris, Liesbet, Capelli, Claudio
Publicado 2023

Turning Nature’s own processes into design strategies for living bone implant biomanufacturing: a decade of Developmental Engineering

por Papantoniou, Ioannis, Nilsson Hall, Gabriella, Loverdou, Niki, Lesage, Raphaelle, Herpelinck, Tim, Mendes, Luis, Geris, Liesbet
Publicado 2021

Discrete adipose-derived stem cell subpopulations may display differential functionality after in vitro expansion despite convergence to a common phenotype distribution

por Nielsen, Frederik Mølgaard, Riis, Simone Elkjær, Andersen, Jens Isak, Lesage, Raphaëlle, Fink, Trine, Pennisi, Cristian Pablo, Zachar, Vladimir
Publicado 2016

An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis

por Lesage, Raphaëlle, Ferrao Blanco, Mauricio N., Narcisi, Roberto, Welting, Tim, van Osch, Gerjo J. V. M., Geris, Liesbet
Publicado 2022

Verifying and Validating Quantitative Systems Pharmacology and In Silico Models in Drug Development: Current Needs, Gaps, and Challenges

por Musuamba, Flora T., Bursi, Roberta, Manolis, Efthymios, Karlsson, Kristin, Kulesza, Alexander, Courcelles, Eulalie, Boissel, Jean‐Pierre, Lesage, Raphaëlle, Crozatier, Cécile, Voisin, Emmanuelle M., Rousseau, Cécile F., Marchal, Thierry, Alessandrello, Rossana, Geris, Liesbet
Publicado 2020

Human pluripotent stem cell-derived cartilaginous organoids promote scaffold-free healing of critical size long bone defects

por Tam, Wai Long, Freitas Mendes, Luís, Chen, Xike, Lesage, Raphaëlle, Van Hoven, Inge, Leysen, Elke, Kerckhofs, Greet, Bosmans, Kathleen, Chai, Yoke Chin, Yamashita, Akihiro, Tsumaki, Noriyuki, Geris, Liesbet, Roberts, Scott J., Luyten, Frank P.
Publicado 2021

Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility

por Musuamba, Flora T., Skottheim Rusten, Ine, Lesage, Raphaëlle, Russo, Giulia, Bursi, Roberta, Emili, Luca, Wangorsch, Gaby, Manolis, Efthymios, Karlsson, Kristin E., Kulesza, Alexander, Courcelles, Eulalie, Boissel, Jean‐Pierre, Rousseau, Cécile F., Voisin, Emmanuelle M., Alessandrello, Rossana, Curado, Nuno, Dall’ara, Enrico, Rodriguez, Blanca, Pappalardo, Francesco, Geris, Liesbet
Publicado 2021