C9orf72 Proteins Regulate Autophagy and Undergo Autophagosomal or Proteasomal Degradation in a Cell Type-Dependent Manner

por Leskelä, Stina, Huber, Nadine, Rostalski, Hannah, Natunen, Teemu, Remes, Anne M., Takalo, Mari, Hiltunen, Mikko, Haapasalo, Annakaisa
Publicado 2019

Deficient neurotransmitter systems and synaptic function in frontotemporal lobar degeneration—Insights into disease mechanisms and current therapeutic approaches

por Huber, Nadine, Korhonen, Sonja, Hoffmann, Dorit, Leskelä, Stina, Rostalski, Hannah, Remes, Anne M., Honkakoski, Paavo, Solje, Eino, Haapasalo, Annakaisa
Publicado 2021

Astrocytes and Microglia as Potential Contributors to the Pathogenesis of C9orf72 Repeat Expansion-Associated FTLD and ALS

por Rostalski, Hannah, Leskelä, Stina, Huber, Nadine, Katisko, Kasper, Cajanus, Antti, Solje, Eino, Marttinen, Mikael, Natunen, Teemu, Remes, Anne M., Hiltunen, Mikko, Haapasalo, Annakaisa
Publicado 2019

FTLD Patient–Derived Fibroblasts Show Defective Mitochondrial Function and Accumulation of p62

por Leskelä, Stina, Hoffmann, Dorit, Rostalski, Hannah, Huber, Nadine, Wittrahm, Rebekka, Hartikainen, Päivi, Korhonen, Ville, Leinonen, Ville, Hiltunen, Mikko, Solje, Eino, Remes, Anne M., Haapasalo, Annakaisa
Publicado 2021

BV-2 Microglial Cells Overexpressing C9orf72 Hexanucleotide Repeat Expansion Produce DPR Proteins and Show Normal Functionality but No RNA Foci

por Rostalski, Hannah, Hietanen, Tomi, Leskelä, Stina, Behánová, Andrea, Abdollahzadeh, Ali, Wittrahm, Rebekka, Mäkinen, Petra, Huber, Nadine, Hoffmann, Dorit, Solje, Eino, Remes, Anne M., Natunen, Teemu, Takalo, Mari, Tohka, Jussi, Hiltunen, Mikko, Haapasalo, Annakaisa
Publicado 2020

DHCR24 exerts neuroprotection upon inflammation-induced neuronal death

por Martiskainen, Henna, Paldanius, Kaisa M. A., Natunen, Teemu, Takalo, Mari, Marttinen, Mikael, Leskelä, Stina, Huber, Nadine, Mäkinen, Petra, Bertling, Enni, Dhungana, Hiramani, Huuskonen, Mikko, Honkakoski, Paavo, Hotulainen, Pirta, Rilla, Kirsi, Koistinaho, Jari, Soininen, Hilkka, Malm, Tarja, Haapasalo, Annakaisa, Hiltunen, Mikko
Publicado 2017

PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease

por Oksanen, Minna, Petersen, Andrew J., Naumenko, Nikolay, Puttonen, Katja, Lehtonen, Šárka, Gubert Olivé, Max, Shakirzyanova, Anastasia, Leskelä, Stina, Sarajärvi, Timo, Viitanen, Matti, Rinne, Juha O., Hiltunen, Mikko, Haapasalo, Annakaisa, Giniatullin, Rashid, Tavi, Pasi, Zhang, Su-Chun, Kanninen, Katja M., Hämäläinen, Riikka H., Koistinaho, Jari
Publicado 2017