Perspective on model‐informed drug development

por Lesko, Lawrence J.
Publicado 2021

Guest Editorial: Regulatory Acceptance of Toxicogenomics Data

por Frueh, Felix W., Huang, Shiew-Mei, Lesko, Lawrence J.
Publicado 2004

Pharmacodynamic Modeling to Evaluate the Impact of Cimetidine, an OCT2 Inhibitor, on the Anticancer Effects of Cisplatin

por Mody, Hardik, Vaidya, Tanaya R., Lesko, Lawrence J., Ait-Oudhia, Sihem
Publicado 2022

Association of Oral Anticoagulants and Verapamil or Diltiazem With Adverse Bleeding Events in Patients With Nonvalvular Atrial Fibrillation and Normal Kidney Function

por Pham, Phuong, Schmidt, Stephan, Lesko, Lawrence, Lip, Gregory Y. H., Brown, Joshua D.
Publicado 2020

Quantitative Systems Pharmacology Model-Based Predictions of Clinical Endpoints to Optimize Warfarin and Rivaroxaban Anti-Thrombosis Therapy

por Hartmann, Sonja, Biliouris, Konstantinos, Lesko, Lawrence J., Nowak-Göttl, Ulrike, Trame, Mirjam N.
Publicado 2020

Advancing drug safety science by integrating molecular knowledge with post‐marketing adverse event reports

por Soldatos, Theodoros G., Kim, Sarah, Schmidt, Stephan, Lesko, Lawrence J., Jackson, David B.
Publicado 2022

Model‐Informed Precision Dosing at the Bedside: Scientific Challenges and Opportunities

por Keizer, Ron J., ter Heine, Rob, Frymoyer, Adam, Lesko, Lawrence J., Mangat, Ranvir, Goswami, Srijib
Publicado 2018

Model‐Based Approach to Predict Adherence to Protocol During Antiobesity Trials

por Sharma, Vishnu D., Combes, François P., Vakilynejad, Majid, Lahu, Gezim, Lesko, Lawrence J., Trame, Mirjam N.
Publicado 2017

A case study of a patient‐centered reverse translational systems‐based approach to understand adverse event profiles in drug development

por Kim, Sarah, Lahu, Gezim, Vakilynejad, Majid, Soldatos, Theodoros G., Jackson, David B., Lesko, Lawrence J., Trame, Mirjam N.
Publicado 2022

Application of a patient‐centered reverse translational systems‐based approach to understand mechanisms of an adverse drug reaction of immune checkpoint inhibitors

por Kim, Sarah, Lahu, Gezim, Vakilynejad, Majid, Soldatos, Theodoros G., Jackson, David B., Lesko, Lawrence J., Trame, Mirjam N.
Publicado 2022

Establishing a Multidisciplinary Framework to Study Drug‐Drug Interactions of Hormonal Contraceptives: An Invitation to Collaborate

por Lesko, Lawrence J., Vozmediano, Valvanera, Brown, Joshua D., Winterstein, Almut, Zhao, Ping, Lippert, Jörg, Höchel, Joachim, Chaturvedula, Ayyappa, White, Annesha, Schmidt, Stephan
Publicado 2018

Evaluation of the Potential for Drug Interactions With Patiromer in Healthy Volunteers

por Lesko, Lawrence J., Offman, Elliot, Brew, Christine Taylor, Garza, Dahlia, Benton, Wade, Mayo, Martha R., Romero, Alain, Du Mond, Charles, Weir, Matthew R.
Publicado 2017

Physiologically‐based pharmacokinetics modeling to investigate formulation factors influencing the generic substitution of dabigatran etexilate

por Farhan, Nashid, Cristofoletti, Rodrigo, Basu, Sumit, Kim, Sarah, Lingineni, Karthik, Jiang, Sibo, Brown, Joshua D., Fang, Lanyan (Lucy), Lesko, Lawrence J., Schmidt, Stephan
Publicado 2021

A Semi‐Mechanistic Population Pharmacokinetic Model of Nusinersen: An Antisense Oligonucleotide for the Treatment of Spinal Muscular Atrophy

por Biliouris, Konstantinos, Gaitonde, Puneet, Yin, Wei, Norris, Daniel A., Wang, Yanfeng, Henry, Scott, Fey, Robert, Nestorov, Ivan, Schmidt, Stephan, Rogge, Mark, Lesko, Lawrence J., Trame, Mirjam N.
Publicado 2018

Dosing Regimen Prediction and Confirmation With Rivaroxaban for Thromboprophylaxis in Children After the Fontan Procedure: Insights From the Phase III UNIVERSE Study

por Zhu, Peijuan, Willmann, Stefan, Zhou, Wangda, Yang, Haitao, Michelson, Alan D., McCrindle, Brian W., Li, Jennifer S., Harris, Kevin C., Pina, Liza Miriam, Weber, Traci, Nessel, Kimberly, Lesko, Lawrence J., Kubitza, Dagmar, Zannikos, Peter
Publicado 2022

Cancer Pharmacogenomics and Pharmacoepidemiology: Setting a Research Agenda to Accelerate Translation

por Freedman, Andrew N., Sansbury, Leah B., Figg, William D., Potosky, Arnold L., Weiss Smith, Sheila R., Khoury, Muin J., Nelson, Stefanie A., Weinshilboum, Richard M., Ratain, Mark J., McLeod, Howard L., Epstein, Robert S., Ginsburg, Geoffrey S., Schilsky, Richard L., Liu, Geoffrey, Flockhart, David A., Ulrich, Cornelia M., Davis, Robert L., Lesko, Lawrence J., Zineh, Issam, Randhawa, Gurvaneet, Ambrosone, Christine B., Relling, Mary V., Rothman, Nat, Xie, Heng, Spitz, Margaret R., Ballard-Barbash, Rachel, Doroshow, James H., Minasian, Lori M.
Publicado 2010