ACRBP (Sp32) is involved in priming sperm for the acrosome reaction and the binding of sperm to the zona pellucida in a porcine model

por Kato, Yoku, Kumar, Satheesh, Lessard, Christian, Bailey, Janice L.
Publicado 2021

γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP)

por Lessard, Christian B., Cottrell, Barbara A., Maruyama, Hiroko, Suresh, Suraj, Golde, Todd E., Koo, Edward H.
Publicado 2015

γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not

por Lessard, Christian B., Rodriguez, Edgardo, Ladd, Thomas B., Minter, Lisa M., Osborne, Barbara A., Miele, Lucio, Golde, Todd E., Ran, Yong
Publicado 2020

γ‐Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct

por Ran, Yong, Hossain, Fokhrul, Pannuti, Antonio, Lessard, Christian B, Ladd, Gabriela Z, Jung, Joo In, Minter, Lisa M, Osborne, Barbara A, Miele, Lucio, Golde, Todd E
Publicado 2017

Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph

por Magno, Lorenza, Lessard, Christian B., Martins, Marta, Lang, Verena, Cruz, Pedro, Asi, Yasmine, Katan, Matilda, Bilsland, Jamie, Lashley, Tammaryn, Chakrabarty, Paramita, Golde, Todd E., Whiting, Paul J.
Publicado 2019

Photodynamic studies reveal rapid formation and appreciable turnover of tau inclusions

por Croft, Cara L., Goodwin, Marshall S., Ryu, Daniel H., Lessard, Christian B., Tejeda, Giancarlo, Marrero, Marc, Vause, Ava R., Paterno, Giavanna, Cruz, Pedro E., Lewis, Jada, Giasson, Benoit I., Golde, Todd E.
Publicado 2021

High‐affinity interactions and signal transduction between Aβ oligomers and TREM2

por Lessard, Christian B, Malnik, Samuel L, Zhou, Yingyue, Ladd, Thomas B, Cruz, Pedro E, Ran, Yong, Mahan, Thomas E, Chakrabaty, Paramita, Holtzman, David M, Ulrich, Jason D, Colonna, Marco, Golde, Todd E
Publicado 2018

Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways

por Ibanez, Kristen R., McFarland, Karen N., Phillips, Jennifer, Allen, Mariet, Lessard, Christian B., Zobel, Lillian, De La Cruz, Elsa Gonzalez, Shah, Shivani, Vo, Quan, Wang, Xue, Quicksall, Zachary, Ryu, Daniel, Funk, Cory, Ertekin-Taner, Nilüfer, Prokop, Stefan, Golde, Todd E., Chakrabarty, Paramita
Publicado 2022