Inhibitors of SARS-CoV-2 PLpro

por Calleja, Dale J., Lessene, Guillaume, Komander, David
Publicado 2022

Dual drug targeting to kill colon cancers

por Corona, Silvia Paola, Walker, Francesca, Weinstock, Janet, Lessene, Guillaume, Faux, Maree, Burgess, Antony W.
Publicado 2022

From (Tool)Bench to Bedside: The Potential of Necroptosis Inhibitors

por Gardner, Christopher R., Davies, Katherine A., Zhang, Ying, Brzozowski, Martin, Czabotar, Peter E., Murphy, James M., Lessene, Guillaume
Publicado 2023

Removal of BFL-1 sensitises some melanoma cells to killing by BH3 mimetic drugs

por Gangoda, Lahiru, Schenk, Robyn L., Tai, Lin, Szeto, Pacman, Cheung, Jen G., Strasser, Andreas, Lessene, Guillaume, Shackleton, Mark, Herold, Marco J.
Publicado 2022

The BH3-only proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL

por Delbridge, Alex RD, Aubrey, Brandon J, Hyland, Craig, Bernardini, Jonathan P, Di Rago, Ladina, Garnier, Jean-Marc, Lessene, Guillaume, Strasser, Andreas, Alexander, Warren S, Grabow, Stephanie
Publicado 2017

Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations

por Birkinshaw, Richard W., Gong, Jia-nan, Luo, Cindy S., Lio, Daisy, White, Christine A., Anderson, Mary Ann, Blombery, Piers, Lessene, Guillaume, Majewski, Ian J., Thijssen, Rachel, Roberts, Andrew W., Huang, David C. S., Colman, Peter M., Czabotar, Peter E.
Publicado 2019

Defining the susceptibility of colorectal cancers to BH3-mimetic compounds

por Luo, Ming-Jie, Palmieri, Michelle, Riffkin, Chris D., Sakthianandeswaren, Anuratha, Djajawi, Tirta Mario, Hirokawa, Yumiko, Shuttleworth, Victoria, Segal, David H., White, Christine A., Nhu, Duong, Lessene, Guillaume, Lee, Margaret, Gibbs, Peter, Huang, David C. S., Sieber, Oliver M., Gong, Jia-nan
Publicado 2020

Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis

por Meng, Yanxiang, Davies, Katherine A., Fitzgibbon, Cheree, Young, Samuel N., Garnish, Sarah E., Horne, Christopher R., Luo, Cindy, Garnier, Jean-Marc, Liang, Lung-Yu, Cowan, Angus D., Samson, Andre L., Lessene, Guillaume, Sandow, Jarrod J., Czabotar, Peter E., Murphy, James M.
Publicado 2021

The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL

por Jacobsen, Annette V., Pierotti, Catia L., Lowes, Kym N., Au, Amanda E., Zhang, Ying, Etemadi, Nima, Fitzgibbon, Cheree, Kersten, Wilhelmus J. A., Samson, André L., van Delft, Mark F., Huang, David C. S., Sabroux, Hélène Jousset, Lessene, Guillaume, Silke, John, Murphy, James M.
Publicado 2022

The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells

por Wang, Zilu, Hu, Huimin, Heitink, Luuk, Rogers, Kelly, You, Yue, Tan, Tao, Suen, Connie Li Wai, Garnham, Alex, Chen, Hao, Lieschke, Elizabeth, Diepstraten, Sarah T., Chang, Catherine, Chen, Tianwei, Moujalled, Diane, Sutherland, Kate, Lessene, Guillaume, Sieber, Oliver M., Visvader, Jane, Kelly, Gemma L., Strasser, Andreas
Publicado 2023

Correction to: The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells

por Wang, Zilu, Hu, Huimin, Heitink, Luuk, Rogers, Kelly, You, Yue, Tan, Tao, Suen, Connie Li Wai, Garnham, Alex, Chen, Hao, Lieschke, Elizabeth, Diepstraten, Sarah T., Chang, Catherine, Chen, Tianwei, Moujalled, Diane, Sutherland, Kate, Lessene, Guillaume, Sieber, Oliver M., Visvader, Jane, Kelly, Gemma L., Strasser, Andreas
Publicado 2023

The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinase

por Pierotti, Catia L., Jacobsen, Annette V., Grohmann, Christoph, Dempsey, Ruby K., Etemadi, Nima, Hildebrand, Joanne M., Fitzgibbon, Cheree, Young, Samuel N., Davies, Katherine A., Kersten, Wilhelmus J. A., Silke, John, Lowes, Kym N., Jousset Sabroux, Hélène, Huang, David C. S., van Delft, Mark F., Murphy, James M., Lessene, Guillaume
Publicado 2023

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

por Berger, Stephanie, Procko, Erik, Margineantu, Daciana, Lee, Erinna F, Shen, Betty W, Zelter, Alex, Silva, Daniel-Adriano, Chawla, Kusum, Herold, Marco J, Garnier, Jean-Marc, Johnson, Richard, MacCoss, Michael J, Lessene, Guillaume, Davis, Trisha N, Stayton, Patrick S, Stoddard, Barry L, Fairlie, W Douglas, Hockenbery, David M, Baker, David
Publicado 2016

Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms

por Grohmann, Christoph, Magtoto, Charlene M., Walker, Joel R., Chua, Ngee Kiat, Gabrielyan, Anna, Hall, Mary, Cobbold, Simon A., Mieruszynski, Stephen, Brzozowski, Martin, Simpson, Daniel S., Dong, Hao, Dorizzi, Bridget, Jacobsen, Annette V., Morrish, Emma, Silke, Natasha, Murphy, James M., Heath, Joan K., Testa, Andrea, Maniaci, Chiara, Ciulli, Alessio, Lessene, Guillaume, Silke, John, Feltham, Rebecca
Publicado 2022

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

por Petrie, Emma J., Sandow, Jarrod J., Jacobsen, Annette V., Smith, Brian J., Griffin, Michael D. W., Lucet, Isabelle S., Dai, Weiwen, Young, Samuel N., Tanzer, Maria C., Wardak, Ahmad, Liang, Lung-Yu, Cowan, Angus D., Hildebrand, Joanne M., Kersten, Wilhelmus J. A., Lessene, Guillaume, Silke, John, Czabotar, Peter E., Webb, Andrew I., Murphy, James M.
Publicado 2018

Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia

por Moujalled, Donia M., Brown, Fiona C., Chua, Chong Chyn, Dengler, Michael A., Pomilio, Giovanna, Anstee, Natasha S., Litalien, Veronique, Thompson, Ella, Morley, Thomas, MacRaild, Sarah, Tiong, Ing S., Morris, Rhiannon, Dun, Karen, Zordan, Adrian, Shah, Jaynish, Banquet, Sebastien, Halilovic, Ensar, Morris, Erick, Herold, Marco J., Lessene, Guillaume, Adams, Jerry M., Huang, David C. S., Roberts, Andrew W., Blombery, Piers, Wei, Andrew H.
Publicado 2023

Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia

por Moujalled, Donia M., Pomilio, Giovanna, Ghiurau, Corina, Ivey, Adam, Salmon, Jessica, Rijal, Sewa, Macraild, Sarah, Zhang, Lan, Teh, Tse-Chieh, Tiong, Ing-Soo, Lan, Ping, Chanrion, Maia, Claperon, Audrey, Rocchetti, Francesca, Zichi, Adrien, Kraus-Berthier, Laurence, Wang, Youzhen, Halilovic, Ensar, Morris, Erick, Colland, Frédéric, Segal, David, Huang, David, Roberts, Andrew W., Maragno, Ana Leticia, Lessene, Guillaume, Geneste, Olivier, Wei, Andrew H.
Publicado 2018

MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis

por Samson, Andre L., Zhang, Ying, Geoghegan, Niall D., Gavin, Xavier J., Davies, Katherine A., Mlodzianoski, Michael J., Whitehead, Lachlan W., Frank, Daniel, Garnish, Sarah E., Fitzgibbon, Cheree, Hempel, Anne, Young, Samuel N., Jacobsen, Annette V., Cawthorne, Wayne, Petrie, Emma J., Faux, Maree C., Shield-Artin, Kristy, Lalaoui, Najoua, Hildebrand, Joanne M., Silke, John, Rogers, Kelly L., Lessene, Guillaume, Hawkins, Edwin D., Murphy, James M.
Publicado 2020

Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors

por Calleja, Dale J., Kuchel, Nathan, Lu, Bernadine G. C., Birkinshaw, Richard W., Klemm, Theresa, Doerflinger, Marcel, Cooney, James P., Mackiewicz, Liana, Au, Amanda E., Yap, Yu Q., Blackmore, Timothy R, Katneni, Kasiram, Crighton, Elly, Newman, Janet, Jarman, Kate E., Call, Melissa J., Lechtenberg, Bernhard C., Czabotar, Peter E., Pellegrini, Marc, Charman, Susan A., Lowes, Kym N., Mitchell, Jeffrey P., Nachbur, Ueli, Lessene, Guillaume, Komander, David
Publicado 2022

Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2

por Klemm, Theresa, Ebert, Gregor, Calleja, Dale J, Allison, Cody C, Richardson, Lachlan W, Bernardini, Jonathan P, Lu, Bernadine GC, Kuchel, Nathan W, Grohmann, Christoph, Shibata, Yuri, Gan, Zhong Yan, Cooney, James P, Doerflinger, Marcel, Au, Amanda E, Blackmore, Timothy R, van der Heden van Noort, Gerbrand J, Geurink, Paul P, Ovaa, Huib, Newman, Janet, Riboldi‐Tunnicliffe, Alan, Czabotar, Peter E, Mitchell, Jeffrey P, Feltham, Rebecca, Lechtenberg, Bernhard C, Lowes, Kym N, Dewson, Grant, Pellegrini, Marc, Lessene, Guillaume, Komander, David
Publicado 2020