STATing the importance of immune modulation by platinum chemotherapeutics

por Hato, Stanleyson V., de Vries, I. Jolanda M., Lesterhuis, W. Joost
Publicado 2012

Programmed Death Ligand 2 in Cancer-Induced Immune Suppression

por Rozali, Esdy N., Hato, Stanleyson V., Robinson, Bruce W., Lake, Richard A., Lesterhuis, W. Joost
Publicado 2012

Cancer chemotherapy: insights into cellular and tumor microenvironmental mechanisms of action

por Tilsed, Caitlin M., Fisher, Scott A., Nowak, Anna K., Lake, Richard A., Lesterhuis, W. Joost
Publicado 2022

A systematic investigation of the maximum tolerated dose of cytotoxic chemotherapy with and without supportive care in mice

por Aston, Wayne J., Hope, Danika E., Nowak, Anna K., Robinson, Bruce W., Lake, Richard A., Lesterhuis, W. Joost
Publicado 2017

Sensitizing the Tumor Microenvironment to Immune Checkpoint Therapy

por Zemek, Rachael M., Chin, Wee Loong, Nowak, Anna K., Millward, Michael J., Lake, Richard A., Lesterhuis, W. Joost
Publicado 2020

The chemotherapeutic drug oxaliplatin differentially affects blood DC function dependent on environmental cues

por Tel, Jurjen, Hato, Stanleyson V., Torensma, Ruurd, Buschow, Sonja I., Figdor, Carl G., Lesterhuis, W. Joost, de Vries, I. Jolanda M.
Publicado 2011

Dexamethasone differentially depletes tumour and peripheral blood lymphocytes and can impact the efficacy of chemotherapy/checkpoint blockade combination treatment

por Aston, Wayne J., Hope, Danika E., Cook, Alistair M., Boon, Louis, Dick, Ian, Nowak, Anna K., Lake, Richard A., Lesterhuis, W. Joost
Publicado 2019

A tipping point in cancer-immune dynamics leads to divergent immunotherapy responses and hampers biomarker discovery

por Creemers, Jeroen H A, Lesterhuis, W Joost, Mehra, Niven, Gerritsen, Winald R, Figdor, Carl G, de Vries, I Jolanda M, Textor, Johannes
Publicado 2021

Neoadjuvant anti-tumor vaccination prior to surgery enhances survival

por Fisher, Scott A, Cleaver, Amanda, Lakhiani, Devina D, Khong, Andrea, Connor, Theresa, Wylie, Ben, Lesterhuis, W Joost, Robinson, Bruce WS, Lake, Richard A
Publicado 2014

Synergistic Effect of CTLA-4 Blockade and Cancer Chemotherapy in the Induction of Anti-Tumor Immunity

por Lesterhuis, W. Joost, Salmons, Joanne, Nowak, Anna K., Rozali, Esdy N., Khong, Andrea, Dick, Ian M., Harken, Julie A., Robinson, Bruce W., Lake, Richard A.
Publicado 2013

Geldanamycin treatment does not result in anti-cancer activity in a preclinical model of orthotopic mesothelioma

por Orozco Morales, M. Lizeth, Rinaldi, Catherine A., de Jong, Emma, Lansley, Sally M., Lee, Y. C. Gary, Zemek, Rachael M., Bosco, Anthony, Lake, Richard A., Lesterhuis, W. Joost
Publicado 2023

Network analysis of immunotherapy-induced regressing tumours identifies novel synergistic drug combinations

por Lesterhuis, W. Joost, Rinaldi, Catherine, Jones, Anya, Rozali, Esdy N., Dick, Ian M., Khong, Andrea, Boon, Louis, Robinson, Bruce W., Nowak, Anna K., Bosco, Anthony, Lake, Richard A.
Publicado 2015

Transient Treg depletion enhances therapeutic anti‐cancer vaccination

por Fisher, Scott A., Aston, Wayne J., Chee, Jonathan, Khong, Andrea, Cleaver, Amanda L., Solin, Jessica N., Ma, Shaokang, Lesterhuis, W. Joost, Dick, Ian, Holt, Robert A., Creaney, Jenette, Boon, Louis, Robinson, Bruce, Lake, Richard A.
Publicado 2016

Strong spontaneous tumor neoantigen responses induced by a natural human carcinogen

por Creaney, Jenette, Ma, Shaokang, Sneddon, Sophie A, Tourigny, Michelle R, Dick, Ian M, Leon, Justine S, Khong, Andrea, Fisher, Scott A, Lake, Richard A, Lesterhuis, W Joost, Nowak, Anna K, Leary, Shay, Watson, Mark W, Robinson, Bruce W
Publicado 2015

Temporally restricted activation of IFNβ signaling underlies response to immune checkpoint therapy in mice

por Zemek, Rachael M., Chin, Wee Loong, Fear, Vanessa S., Wylie, Ben, Casey, Thomas H., Forbes, Cath, Tilsed, Caitlin M., Boon, Louis, Guo, Belinda B., Bosco, Anthony, Forrest, Alistair R. R., Millward, Michael J., Nowak, Anna K., Lake, Richard A., Lassmann, Timo, Lesterhuis, W. Joost
Publicado 2022

PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective

por Orozco Morales, M. Lizeth, Rinaldi, Catherine A., de Jong, Emma, Lansley, Sally M., Gummer, Joel P.A., Olasz, Bence, Nambiar, Shabarinath, Hope, Danika E., Casey, Thomas H., Lee, Y. C. Gary, Leslie, Connull, Nealon, Gareth, Shackleford, David M., Powell, Andrew K., Grimaldi, Marina, Balaguer, Patrick, Zemek, Rachael M., Bosco, Anthony, Piggott, Matthew J., Vrielink, Alice, Lake, Richard A., Lesterhuis, W. Joost
Publicado 2021

Autologous monocyte-derived DC vaccination combined with cisplatin in stage III and IV melanoma patients: a prospective, randomized phase 2 trial

por Boudewijns, Steve, Bloemendal, Martine, de Haas, Nienke, Westdorp, Harm, Bol, Kalijn F., Schreibelt, Gerty, Aarntzen, Erik H. J. G., Lesterhuis, W. Joost, Gorris, Mark A. J., Croockewit, Alexandra, van der Woude, Lieke L., van Rossum, Michelle M., Welzen, Marieke, de Goede, Anna, Hato, Stanleyson V., van der Graaf, Winette T. A., Punt, Cornelis J. A., Koornstra, Rutger H. T., Gerritsen, Winald R., Figdor, Carl G., de Vries, I. Jolanda M.
Publicado 2020