Emerging Advances in Combinatorial Treatments of Epigenetically Altered Pediatric High-Grade H3K27M Gliomas

por Leszczynska, Katarzyna B., Jayaprakash, Chinchu, Kaminska, Bozena, Mieczkowski, Jakub
Publicado 2021

The imidazoacridinone C-1311 induces p53-dependent senescence or p53-independent apoptosis and sensitizes cancer cells to radiation

por Skwarska, Anna, Ramachandran, Shaliny, Dobrynin, Grzegorz, Leszczynska, Katarzyna B., Hammond, Ester M.
Publicado 2017

OTME-2. Regulation of chromatin accessibility in the hypoxic tumor microenvironment of glioblastoma

por Dzwigonska, Monika, Mieczkowski, Jakub, Pilanc, Paulina, Cyranowski, Salwador, Kominek, Agata, Piwocka, Katarzyna, Kaminska, Bozena, Leszczynska, Katarzyna B
Publicado 2021

KDM4A regulates HIF-1 levels through H3K9me3

por Dobrynin, Grzegorz, McAllister, Tom E., Leszczynska, Katarzyna B., Ramachandran, Shaliny, Krieg, Adam J., Kawamura, Akane, Hammond, Ester M.
Publicado 2017

Hypoxia‐mediated regulation of DDX5 through decreased chromatin accessibility and post‐translational targeting restricts R‐loop accumulation

por Leszczynska, Katarzyna B., Dzwigonska, Monika, Estephan, Hala, Moehlenbrink, Jutta, Bowler, Elizabeth, Giaccia, Amato J., Mieczkowski, Jakub, Kaminska, Bozena, Hammond, Ester M.
Publicado 2023

Hypoxia Potentiates the Radiation-Sensitizing Effect of Olaparib in Human Non-Small Cell Lung Cancer Xenografts by Contextual Synthetic Lethality

por Jiang, Yanyan, Verbiest, Tom, Devery, Aoife M., Bokobza, Sivan M., Weber, Anika M., Leszczynska, Katarzyna B., Hammond, Ester M., Ryan, Anderson J.
Publicado 2016

Mechanisms and consequences of ATMIN repression in hypoxic conditions: roles for p53 and HIF-1

por Leszczynska, Katarzyna B., Göttgens, Eva-Leonne, Biasoli, Deborah, Olcina, Monica M., Ient, Jonathan, Anbalagan, Selvakumar, Bernhardt, Stephan, Giaccia, Amato J., Hammond, Ester M.
Publicado 2016

WSB-1 regulates the metastatic potential of hormone receptor negative breast cancer

por Poujade, Flore-Anne, Mannion, Aarren, Brittain, Nicholas, Theodosi, Andrew, Beeby, Ellie, Leszczynska, Katarzyna B., Hammond, Ester M., Greenman, John, Cawthorne, Christopher, Pires, Isabel M.
Publicado 2018

Preclinical testing of an Atr inhibitor demonstrates improved response to standard therapies for esophageal cancer

por Leszczynska, Katarzyna B., Dobrynin, Greg, Leslie, Rhea E., Ient, Jonathan, Boumelha, Adam J., Senra, Joana M., Hawkins, Maria A., Maughan, Tim, Mukherjee, Somnath, Hammond, Ester M.
Publicado 2016

Pharmacological Inhibition of ATR Can Block Autophagy through an ATR-Independent Mechanism

por Bowler, Elizabeth, Skwarska, Anna, Wilson, Joseph D., Ramachandran, Shaliny, Bolland, Hannah, Easton, Alistair, Ostheimer, Christian, Hwang, Ming-Shih, Leszczynska, Katarzyna B., Conway, Stuart J., Hammond, Ester M.
Publicado 2020

Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication

por Foskolou, Iosifina P., Jorgensen, Christian, Leszczynska, Katarzyna B., Olcina, Monica M., Tarhonskaya, Hanna, Haisma, Bauke, D’Angiolella, Vincenzo, Myers, William K., Domene, Carmen, Flashman, Emily, Hammond, Ester M.
Publicado 2017

Hypoxia-induced SETX links replication stress with the unfolded protein response

por Ramachandran, Shaliny, Ma, Tiffany S., Griffin, Jon, Ng, Natalie, Foskolou, Iosifina P., Hwang, Ming-Shih, Victori, Pedro, Cheng, Wei-Chen, Buffa, Francesca M., Leszczynska, Katarzyna B., El-Khamisy, Sherif F., Gromak, Natalia, Hammond, Ester M.
Publicado 2021

Identification of Histone Peptide Binding Specificity and Small-Molecule Ligands for the TRIM33α and TRIM33β Bromodomains

por Sekirnik, Angelina R., Reynolds, Jessica K., See, Larissa, Bluck, Joseph P., Scorah, Amy R., Tallant, Cynthia, Lee, Bernadette, Leszczynska, Katarzyna B., Grimley, Rachel L., Storer, R. Ian, Malattia, Marta, Crespillo, Sara, Caria, Sofia, Duclos, Stephanie, Hammond, Ester M., Knapp, Stefan, Morris, Garrett M., Duarte, Fernanda, Biggin, Philip C., Conway, Stuart J.
Publicado 2022