Puma strikes Bax

por Letai, Anthony
Publicado 2009

Displacement of Bim by Bmf and Puma rather than increase in Bim level mediates paclitaxel-induced apoptosis in breast cancer cells

por Kutuk, Ozgur, Letai, Anthony
Publicado 2010

Priming BCL-2 to kill: the combination therapy of tamoxifen and ABT-199 in ER(+) breast cancer

por Deng, Jing, Letai, Anthony
Publicado 2013

Dynamic BH3 profiling identifies active BH3 mimetic combinations in non-small cell lung cancer

por Potter, Danielle S., Du, Ruochen, Bhola, Patrick, Bueno, Raphael, Letai, Anthony
Publicado 2021

MCL-1–dependent leukemia cells are more sensitive to chemotherapy than BCL-2–dependent counterparts

por Brunelle, Joslyn K., Ryan, Jeremy, Yecies, Derek, Opferman, Joseph T., Letai, Anthony
Publicado 2009

Designed BH3 Peptides with High Affinity and Specificity for Targeting Mcl-1 in Cells

por Foight, Glenna Wink, Ryan, Jeremy A., Gullá, Stefano V., Letai, Anthony, Keating, Amy E.
Publicado 2014

Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1

por Jenson, Justin M, Ryan, Jeremy A, Grant, Robert A, Letai, Anthony, Keating, Amy E
Publicado 2017

Bruton’s tyrosine kinase inhibition increases BCL-2 dependence and enhances sensitivity to venetoclax in chronic lymphocytic leukemia

por Deng, Jing, Isik, Elif, Fernandes, Stacey M., Brown, Jennifer R., Letai, Anthony, Davids, Matthew S.
Publicado 2017

Targeting conditioned media dependencies and FLT-3 in chronic lymphocytic leukemia

por Parvin, Salma, Aryal, Aditi, Yin, Shanye, Fell, Geoffrey G., Davids, Matthew S., Wu, Catherine J., Letai, Anthony
Publicado 2023

Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance

por Kale, Justin, Kutuk, Ozgur, Brito, Glauber Costa, Andrews, Tallulah S, Leber, Brian, Letai, Anthony, Andrews, David W
Publicado 2018

Dynamic BH3 profiling identifies pro-apoptotic drug combinations for the treatment of malignant pleural mesothelioma

por Potter, Danielle S., Du, Ruochen, Bohl, Stephan R., Chow, Kin-Hoe, Ligon, Keith L., Bueno, Raphael, Letai, Anthony
Publicado 2023

Cristae remodeling causes acidification detected by integrated graphene sensor during mitochondrial outer membrane permeabilization

por Pham, Ted D., Pham, Phi Q., Li, Jinfeng, Letai, Anthony G., Wallace, Douglas C., Burke, Peter J.
Publicado 2016

ER+ Breast Cancer Strongly Depends on MCL-1 and BCL-xL Anti-Apoptotic Proteins

por Alcon, Clara, Zañudo, Jorge Gómez Tejeda, Albert, Reka, Wagle, Nikhil, Scaltriti, Maurizio, Letai, Anthony, Samitier, Josep, Montero, Joan
Publicado 2021

Complementary dynamic BH3 profiles predict co-operativity between the multi-kinase inhibitor TG02 and the BH3 mimetic ABT-199 in acute myeloid leukaemia cells

por Pallis, Monica, Burrows, Francis, Ryan, Jeremy, Grundy, Martin, Seedhouse, Claire, Abdul-Aziz, Amina, Montero, Joan, Letai, Anthony, Russell, Nigel
Publicado 2016

Quantifying requirements for mitochondrial apoptosis in CAR T killing of cancer cells

por Pourzia, Alexandra L., Olson, Michael L., Bailey, Stefanie R., Boroughs, Angela C., Aryal, Aditi, Ryan, Jeremy, Maus, Marcela V., Letai, Anthony
Publicado 2023

Defining specificity and on-target activity of BH3-mimetics using engineered B-ALL cell lines

por Koss, Brian, Ryan, Jeremy, Budhraja, Amit, Szarama, Katherine, Yang, Xue, Bathina, Madhavi, Cardone, Michael H., Nikolovska-Coleska, Zaneta, Letai, Anthony, Opferman, Joseph T.
Publicado 2016

Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage

por Gutierrez-Martinez, Paula, Hogdal, Leah, Nagai, Manavi, Kruta, Miriama, Singh, Rumani, Sarosiek, Kristopher, Nussenzweig, Andre, Beerman, Isabel, Letai, Anthony, Rossi, Derrick J.
Publicado 2018

BH3-profiling identifies heterogeneous dependency on Bcl-2 family members in Multiple Myeloma and predicts sensitivity to BH3 mimetics

por Touzeau, Cyrille, Ryan, Jeremy, Guerriero, Jennifer L., Moreau, Philippe, Chonghaile, Triona Ni, Gouill, Steven Le, Richardson, Paul, Anderson, Kenneth, Amiot, Martine, Letai, Anthony
Publicado 2015

P324: CELL PLASTICITY PREDETERMINES TREATMENT RESPONSE IN T-ALL

por Dimitrova, Valeriya, Frede, Julia, Montanaro, Anna, Potdar, Sayalee, Stuart, Hannah, Sotoudeh, Noori, Van Scoyk, Alexandria, Bhatt, Shruti, Letai, Anthony, Aster, Jon, Lohr, Jens, Knoechel, Birgit
Publicado 2023

Comparing syngeneic and autochthonous models of breast cancer to identify tumor immune components that correlate with response to immunotherapy in breast cancer

por Lal, Jessica Castrillon, Townsend, Madeline G., Mehta, Anita K., Oliwa, Madisson, Miller, Eric, Sotayo, Alaba, Cheney, Emily, Mittendorf, Elizabeth A., Letai, Anthony, Guerriero, Jennifer L.
Publicado 2021