Stability and safety key factors of the oncolytic protoparvovirus H-1 from manufacturing to human application

por Frehtman, Veronika, Wohlfarth, Daniel, Müller, Marcus, Krebs, Ottheinz, Leuchs, Barbara
Publicado 2023

A novel scalable, robust downstream process for oncolytic rat parvovirus: isoelectric point-based elimination of empty particles

por Leuchs, Barbara, Frehtman, Veronika, Riese, Markus, Müller, Marcus, Rommelaere, Jean
Publicado 2017

Upstream process optimization and micro- and macrocarrier screening for large-scale production of the oncolytic H-1 protoparvovirus

por Wohlfarth, Daniel, Frehtman, Veronika, Müller, Marcus, Vogel, Martin, Phan, Linh Minh Phuc, Brunecker, Adrian, Leuchs, Barbara
Publicado 2021

Preclinical Testing of an Oncolytic Parvovirus: Standard Protoparvovirus H-1PV Efficiently Induces Osteosarcoma Cell Lysis In Vitro

por Geiss, Carsten, Kis, Zoltán, Leuchs, Barbara, Frank-Stöhr, Monika, Schlehofer, Jörg R., Rommelaere, Jean, Dinsart, Christiane, Lacroix, Jeannine
Publicado 2017

Activation of the human immune system by chemotherapeutic or targeted agents combined with the oncolytic parvovirus H-1

por Moehler, Markus, Sieben, Maike, Roth, Susanne, Springsguth, Franziska, Leuchs, Barbara, Zeidler, Maja, Dinsart, Christiane, Rommelaere, Jean, Galle, Peter R
Publicado 2011

Moving oncolytic viruses into the clinic: clinical-grade production, purification, and characterization of diverse oncolytic viruses

por Ungerechts, Guy, Bossow, Sascha, Leuchs, Barbara, Holm, Per S, Rommelaere, Jean, Coffey, Matt, Coffin, Rob, Bell, John, Nettelbeck, Dirk M
Publicado 2016

TLR-9 Contributes to the Antiviral Innate Immune Sensing of Rodent Parvoviruses MVMp and H-1PV by Normal Human Immune Cells

por Raykov, Zahari, Grekova, Svitlana P., Hörlein, Rita, Leuchs, Barbara, Giese, Thomas, Giese, Nathalia A., Rommelaere, Jean, Zawatzky, Rainer, Daeffler, Laurent
Publicado 2013

Screening of Human Tumor Antigens for CD4(+) T Cell Epitopes by Combination of HLA-Transgenic Mice, Recombinant Adenovirus and Antigen Peptide Libraries

por Osen, Wolfram, Soltek, Sabine, Song, Mingxia, Leuchs, Barbara, Steitz, Julia, Tüting, Thomas, Eichmüller, Stefan B., Nguyen, Xuan-Duc, Schadendorf, Dirk, Paschen, Annette
Publicado 2010

Phase I/IIa study of intratumoral/intracerebral or intravenous/intracerebral administration of Parvovirus H-1 (ParvOryx) in patients with progressive primary or recurrent glioblast...

por Geletneky, Karsten, Huesing, Johannes, Rommelaere, Jean, Schlehofer, Joerg R, Leuchs, Barbara, Dahm, Michael, Krebs, Ottheinz, von Knebel Doeberitz, Magnus, Huber, Bernard, Hajda, Jacek
Publicado 2012

Focal Delivery of AAV2/1-transgenes Into the Rat Brain by Localized Ultrasound-induced BBB Opening

por Alonso, Angelika, Reinz, Eileen, Leuchs, Barbara, Kleinschmidt, Jürgen, Fatar, Marc, Geers, Bart, Lentacker, Ine, Hennerici, Michael G., de Smedt, Stefaan C., Meairs, Stephen
Publicado 2013

Preclinical Testing of an Oncolytic Parvovirus in Ewing Sarcoma: Protoparvovirus H-1 Induces Apoptosis and Lytic Infection In Vitro but Fails to Improve Survival In Vivo

por Lacroix, Jeannine, Kis, Zoltán, Josupeit, Rafael, Schlund, Franziska, Stroh-Dege, Alexandra, Frank-Stöhr, Monika, Leuchs, Barbara, Schlehofer, Jörg R., Rommelaere, Jean, Dinsart, Christiane
Publicado 2018

Pediatric and Adult High-Grade Glioma Stem Cell Culture Models Are Permissive to Lytic Infection with Parvovirus H-1

por Josupeit, Rafael, Bender, Sebastian, Kern, Sonja, Leuchs, Barbara, Hielscher, Thomas, Herold-Mende, Christel, Schlehofer, Jörg R., Dinsart, Christiane, Witt, Olaf, Rommelaere, Jean, Lacroix, Jeannine
Publicado 2016

Oncolytic effects of parvovirus H-1 in medulloblastoma are associated with repression of master regulators of early neurogenesis

por Lacroix, Jeannine, Schlund, Franziska, Leuchs, Barbara, Adolph, Kathrin, Sturm, Dominik, Bender, Sebastian, Hielscher, Thomas, Pfister, Stefan M, Witt, Olaf, Rommelaere, Jean, Schlehofer, Jörg R, Witt, Hendrik
Publicado 2014

THER-01. Precision brain tumor therapy by AAV-mediated oncogene editing

por von Soosten, Laura, Haar, Janina, Frehtman, Veronika, Holderbach, Stefan, zu Belzen, Julius Upmeier, Jendrusch, Michael, Okonechnikov, Konstantin, Pfister, Stefan M, Grimm, Dirk, Leuchs, Barbara, Jones, David, Kutscher, Lena M, Zuckermann, Marc
Publicado 2022

Human Retrotransposons and the Global Shutdown of Homeostatic Innate Immunity by Oncolytic Parvovirus H-1PV in Pancreatic Cancer

por Neulinger-Muñoz, Matthias, Schaack, Dominik, Grekova, Svetlana P., Bauer, Andrea S., Giese, Thomas, Salg, Gabriel A., Espinet, Elisa, Leuchs, Barbara, Heller, Anette, Nüesch, Jürg P. F., Schenk, Miriam, Volkmar, Michael, Giese, Nathalia A.
Publicado 2021

A non-controlled, single arm, open label, phase II study of intravenous and intratumoral administration of ParvOryx in patients with metastatic, inoperable pancreatic cancer: ParvO...

por Hajda, Jacek, Lehmann, Monika, Krebs, Ottheinz, Kieser, Meinhard, Geletneky, Karsten, Jäger, Dirk, Dahm, Michael, Huber, Bernard, Schöning, Tilman, Sedlaczek, Oliver, Stenzinger, Albrecht, Halama, Niels, Daniel, Volker, Leuchs, Barbara, Angelova, Assia, Rommelaere, Jean, Engeland, Christine E., Springfeld, Christoph, Ungerechts, Guy
Publicado 2017

TSC22D4 is a molecular output of hepatic wasting metabolism

por Jones, Allan, Friedrich, Kilian, Rohm, Maria, Schäfer, Michaela, Algire, Carolyn, Kulozik, Philipp, Seibert, Oksana, Müller-Decker, Karin, Sijmonsma, Tjeerd, Strzoda, Daniela, Sticht, Carsten, Gretz, Norbert, Dallinga-Thie, Geesje M, Leuchs, Barbara, Kögl, Manfred, Stremmel, Wolfgang, Diaz, Mauricio Berriel, Herzig, Stephan
Publicado 2013

Oncolytic H-1 Parvovirus Shows Safety and Signs of Immunogenic Activity in a First Phase I/IIa Glioblastoma Trial

por Geletneky, Karsten, Hajda, Jacek, Angelova, Assia L., Leuchs, Barbara, Capper, David, Bartsch, Andreas J., Neumann, Jan-Oliver, Schöning, Tilman, Hüsing, Johannes, Beelte, Birgit, Kiprianova, Irina, Roscher, Mandy, Bhat, Rauf, von Deimling, Andreas, Brück, Wolfgang, Just, Alexandra, Frehtman, Veronika, Löbhard, Stephanie, Terletskaia-Ladwig, Elena, Fry, Jeremy, Jochims, Karin, Daniel, Volker, Krebs, Ottheinz, Dahm, Michael, Huber, Bernard, Unterberg, Andreas, Rommelaere, Jean
Publicado 2017