The chemical stability of abasic RNA compared to abasic DNA

por Küpfer, Pascal A., Leumann, Christian J.
Publicado 2007

Synthesis, base pairing properties and trans-lesion synthesis by reverse transcriptases of oligoribonucleotides containing the oxidatively damaged base 5-hydroxycytidine

por Küpfer, Pascal A., Leumann, Christian J.
Publicado 2011

Therapeutic Potential of Tricyclo-DNA antisense oligonucleotides

por Goyenvalle, Aurelie, Leumann, Christian, Garcia, Luis
Publicado 2016

Nucleic acid sensing by an orthogonal reporter system based on homo-DNA

por Stoop, Matthias, Désiron, Camille, Leumann, Christian J.
Publicado 2013

Structure/affinity studies in the bicyclo-DNA series: Synthesis and properties of oligonucleotides containing bc(en)-T and iso-tricyclo-T nucleosides

por Dugovic, Branislav, Wagner, Michael, Leumann, Christian J
Publicado 2014

6’-Fluoro[4.3.0]bicyclo nucleic acid: synthesis, biophysical properties and molecular dynamics simulations

por Frei, Sibylle, Istrate, Andrei, Leumann, Christian J
Publicado 2018

Position-dependent effects on stability in tricyclo-DNA modified oligonucleotide duplexes

por Ittig, Damian, Gerber, Anna-Barbara, Leumann, Christian J.
Publicado 2011

The effect of RNA base lesions on mRNA translation

por Calabretta, Alessandro, Küpfer, Pascal A., Leumann, Christian J.
Publicado 2015

Synthesis, biophysical properties, and RNase H activity of 6’-difluoro[4.3.0]bicyclo-DNA

por Frei, Sibylle, Katolik, Adam K, Leumann, Christian J
Publicado 2019

Molecular beacons with a homo-DNA stem: improving target selectivity

por Crey-Desbiolles, Caroline, Ahn, Dae-Ro, Leumann, Christian J.
Publicado 2005

Trans-lesion synthesis and RNaseH activity by reverse transcriptases on a true abasic RNA template

por Küpfer, Pascal A., Crey-Desbiolles, Caroline, Leumann, Christian J.
Publicado 2007

NMR solution structure of tricyclo-DNA containing duplexes: insight into enhanced thermal stability and nuclease resistance

por Istrate, Andrei, Johannsen, Silke, Istrate, Alena, Sigel, Roland K O, Leumann, Christian J
Publicado 2019

Oxidative stress damages rRNA inside the ribosome and differentially affects the catalytic center

por Willi, Jessica, Küpfer, Pascal, Evéquoz, Damien, Fernandez, Guillermo, Katz, Assaf, Leumann, Christian, Polacek, Norbert
Publicado 2018

3CAPS – a structural AP–site analogue as a tool to investigate DNA base excision repair

por Schuermann, David, Scheidegger, Simon P., Weber, Alain R., Bjørås, Magnar, Leumann, Christian J., Schär, Primo
Publicado 2016

Efficient SMN Rescue following Subcutaneous Tricyclo-DNA Antisense Oligonucleotide Treatment

por Robin, Valérie, Griffith, Graziella, Carter, John-Paul L., Leumann, Christian J., Garcia, Luis, Goyenvalle, Aurélie
Publicado 2017

Efficacy and Safety Profile of Tricyclo-DNA Antisense Oligonucleotides in Duchenne Muscular Dystrophy Mouse Model

por Relizani, Karima, Griffith, Graziella, Echevarría, Lucía, Zarrouki, Faouzi, Facchinetti, Patricia, Vaillend, Cyrille, Leumann, Christian, Garcia, Luis, Goyenvalle, Aurélie
Publicado 2017

7′,5′-alpha-bicyclo-DNA: new chemistry for oligonucleotide exon splicing modulation therapy

por Evéquoz, Damien, Verhaart, Ingrid E C, van de Vijver, Davy, Renner, Wolfgang, Aartsma-Rus, Annemieke, Leumann, Christian J
Publicado 2021

TricycloDNA-modified oligo-2′-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues—a comparative study of oligonucleotide length, design and...

por Murray, Sue, Ittig, Damian, Koller, Erich, Berdeja, Andres, Chappell, Alfred, Prakash, Thazha P., Norrbom, Michaela, Swayze, Eric E., Leumann, Christian J., Seth, Punit P.
Publicado 2012