Protein-Directed Dynamic Combinatorial Chemistry: A Guide to Protein Ligand and Inhibitor Discovery

por Huang, Renjie, Leung, Ivanhoe K. H.
Publicado 2016

Novel Thermophilic Bacterial Laccase for the Degradation of Aromatic Organic Pollutants

por Sharma, Nabangshu, Leung, Ivanhoe K.H.
Publicado 2021

Identification of Isoform-Selective Ligands for the Middle Domain of Heat Shock Protein 90 (Hsp90)

por Mak, Oi Wei, Chand, Raina, Reynisson, Jóhannes, Leung, Ivanhoe K. H.
Publicado 2019

Phosphatidylcholine-Specific Phospholipase C as a Promising Drug Target

por Eurtivong, Chatchakorn, Leung, Euphemia, Sharma, Nabangshu, Leung, Ivanhoe K. H., Reynisson, Jóhannes
Publicado 2023

Protein-ligand binding affinity determination by the waterLOGSY method: An optimised approach considering ligand rebinding

por Huang, Renjie, Bonnichon, Arnaud, Claridge, Timothy D. W., Leung, Ivanhoe K. H.
Publicado 2017

Oxygenase-Catalyzed Desymmetrization of N,N-Dialkyl-piperidine-4-carboxylic Acids**

por Rydzik, Anna M, Leung, Ivanhoe K H, Kochan, Grazyna T, McDonough, Michael A, Claridge, Timothy D W, Schofield, Christopher J
Publicado 2014

Sensory, Microbiological and Physicochemical Characterisation of Functional Manuka Honey Yogurts Containing Probiotic Lactobacillus reuteri DPC16

por Mohan, Anand, Hadi, Joshua, Gutierrez-Maddox, Noemi, Li, Yu, Leung, Ivanhoe K. H., Gao, Yihuai, Shu, Quan, Quek, Siew-Young
Publicado 2020

Development of NMR and thermal shift assays for the evaluation of Mycobacterium tuberculosis isocitrate lyase inhibitors

por Bhusal, Ram Prasad, Patel, Krunal, Kwai, Brooke X. C., Swartjes, Anne, Bashiri, Ghader, Reynisson, Jóhannes, Sperry, Jonathan, Leung, Ivanhoe K. H.
Publicado 2017

Studies on the Glutathione-Dependent Formaldehyde-Activating Enzyme from Paracoccus denitrificans

por Hopkinson, Richard J., Leung, Ivanhoe K. H., Smart, Tristan J., Rose, Nathan R., Henry, Luc, Claridge, Timothy D. W., Schofield, Christopher J.
Publicado 2015

An improved method for the heterologous production of soluble human ribosomal proteins in Escherichia coli

por Correddu, Danilo, Montaño López, José de Jesús, Vadakkedath, Praveen G., Lai, Amy, Pernes, Jane I., Watson, Paris R., Leung, Ivanhoe K. H.
Publicado 2019

Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2

por Bhusal, Ram Prasad, Jiao, Wanting, Kwai, Brooke X. C., Reynisson, Jóhannes, Collins, Annabelle J., Sperry, Jonathan, Bashiri, Ghader, Leung, Ivanhoe K. H.
Publicado 2019

A novel tyrosine hyperoxidation enables selective peptide cleavage

por Zhang, Shengping, De Leon Rodriguez, Luis M., Li, Freda F., Huang, Renjie, Leung, Ivanhoe K. H., Harris, Paul W. R., Brimble, Margaret A.
Publicado 2022

A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2H-chromen-4-ol Scaffold

por Li-Zhulanov, Nikolai S., Zakharenko, Alexandra L., Chepanova, Arina A., Patel, Jinal, Zafar, Ayesha, Volcho, Konstantin P., Salakhutdinov, Nariman F., Reynisson, Jóhannes, Leung, Ivanhoe K. H., Lavrik, Olga I.
Publicado 2018

Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases

por Tarhonskaya, Hanna, Rydzik, Anna M., Leung, Ivanhoe K. H., Loik, Nikita D., Chan, Mun Chiang, Kawamura, Akane, McCullagh, James S. O., Claridge, Timothy D. W., Flashman, Emily, Schofield, Christopher J.
Publicado 2014

2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2

por Abboud, Martine I., McAllister, Tom E., Leung, Ivanhoe K. H., Chowdhury, Rasheduzzaman, Jorgensen, Christian, Domene, Carmen, Mecinović, Jasmin, Lippl, Kerstin, Hancock, Rebecca L., Hopkinson, Richard J., Kawamura, Akane, Claridge, Timothy D. W., Schofield, Christopher J.
Publicado 2018

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases

por Chowdhury, Rasheduzzaman, Leung, Ivanhoe K. H., Tian, Ya-Min, Abboud, Martine I., Ge, Wei, Domene, Carmen, Cantrelle, François-Xavier, Landrieu, Isabelle, Hardy, Adam P., Pugh, Christopher W., Ratcliffe, Peter J., Claridge, Timothy D. W., Schofield, Christopher J.
Publicado 2016

Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs

por Leung, Euphemia, Patel, Jinal, Hollywood, Jennifer A., Zafar, Ayesha, Tomek, Petr, Barker, David, Pilkington, Lisa I., van Rensburg, Michelle, Langley, Ries J., Helsby, Nuala A., Squire, Christopher J., Baguley, Bruce C., Denny, William A., Reynisson, Jóhannes, Leung, Ivanhoe K. H.
Publicado 2021

Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors

por Shishodia, Shifali, Demetriades, Marina, Zhang, Dong, Tam, Nok Yin, Maheswaran, Pratheesh, Clunie-O’Connor, Caitlin, Tumber, Anthony, Leung, Ivanhoe K. H., Ng, Yi Min, Leissing, Thomas M., El-Sagheer, Afaf H., Salah, Eidarus, Brown, Tom, Aik, Wei Shen, McDonough, Michael A., Schofield, Christopher J.
Publicado 2021

Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain

por Chan, Mun Chiang, Atasoylu, Onur, Hodson, Emma, Tumber, Anthony, Leung, Ivanhoe K. H., Chowdhury, Rasheduzzaman, Gómez-Pérez, Verónica, Demetriades, Marina, Rydzik, Anna M., Holt-Martyn, James, Tian, Ya-Min, Bishop, Tammie, Claridge, Timothy D. W., Kawamura, Akane, Pugh, Christopher W., Ratcliffe, Peter J., Schofield, Christopher J.
Publicado 2015

New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors

por Filimonov, Aleksander S., Chepanova, Arina A., Luzina, Olga A., Zakharenko, Alexandra L., Zakharova, Olga D., Ilina, Ekaterina S., Dyrkheeva, Nadezhda S., Kuprushkin, Maxim S., Kolotaev, Anton V., Khachatryan, Derenik S., Patel, Jinal, Leung, Ivanhoe K.H., Chand, Raina, Ayine-Tora, Daniel M., Reynisson, Johannes, Volcho, Konstantin P., Salakhutdinov, Nariman F., Lavrik, Olga I.
Publicado 2019