Tolerogenic nanoparticles mitigate the formation of anti-drug antibodies against pegylated uricase in patients with hyperuricemia

por Sands, Earl, Kivitz, Alan, DeHaan, Wesley, Leung, Sheldon S., Johnston, Lloyd, Kishimoto, Takashi Kei
Publicado 2022

Readministration of high-dose adeno-associated virus gene therapy vectors enabled by ImmTOR nanoparticles combined with B cell-targeted agents

por Ilyinskii, Petr O, Roy, Christopher, Michaud, Alicia, Rizzo, Gina, Capela, Teresa, Leung, Sheldon S, Kishimoto, Takashi Kei
Publicado 2023

Enhancement of liver-directed transgene expression at initial and repeat doses of AAV vectors admixed with ImmTOR nanoparticles

por Ilyinskii, Petr O., Michaud, Alicia M., Roy, Christopher J., Rizzo, Gina L., Elkins, Stephanie L., Capela, Teresa, Chowdhury, Aparajita C., Leung, Sheldon S., Kishimoto, Takashi K.
Publicado 2021

Phase 2 Dose-Finding Study in Patients with Gout Using SEL-212, a Novel PEGylated Uricase (SEL-037) Combined with Tolerogenic Nanoparticles (SEL-110)

por Kivitz, Alan, DeHaan, Wesley, Azeem, Rehan, Park, Justin, Rhodes, Sheri, Inshaw, Jamie, Leung, Sheldon S., Nicolaou, Savvas, Johnston, Lloyd, Kishimoto, Takashi K., Traber, Peter G., Sands, Earl, Choi, Hyon
Publicado 2023

ImmTOR nanoparticles enhance AAV transgene expression after initial and repeat dosing in a mouse model of methylmalonic acidemia

por Ilyinskii, Petr O., Michaud, Alicia M., Rizzo, Gina L., Roy, Christopher J., Leung, Sheldon S., Elkins, Stephanie L., Capela, Teresa, Chowdhury, Aparajita, Li, Lina, Chandler, Randy J., Manoli, Irini, Andres-Mateos, Eva, Johnston, Lloyd P.M., Vandenberghe, Luk H., Venditti, Charles P., Kishimoto, Takashi Kei
Publicado 2021