A NanoBRET-Based H(3)R Conformational Biosensor to Study Real-Time H(3) Receptor Pharmacology in Cell Membranes and Living Cells

por Ma, Xiaoyuan, Gao, Meichun, Vischer, Henry F., Leurs, Rob
Publicado 2022

Structural Optimization of BIPPO Analogs as Potent Antimalarials

por Zheng, Yang, Matheeussen, An, Maes, Louis, Caljon, Guy, Sterk, Geert Jan, Leurs, Rob
Publicado 2023

Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors

por de Munnik, Sabrina M., Smit, Martine J., Leurs, Rob, Vischer, Henry F.
Publicado 2015

Analysis of Missense Variants in the Human Histamine Receptor Family Reveals Increased Constitutive Activity of E410(6.30×30)K Variant in the Histamine H(1) Receptor

por Ma, Xiaoyuan, Segura, Marta Arimont, Zarzycka, Barbara, Vischer, Henry F., Leurs, Rob
Publicado 2021

Identification of TSPAN4 as Novel Histamine H(4) Receptor Interactor

por Ma, Xiaoyuan, Verweij, Eléonore W. E., Siderius, Marco, Leurs, Rob, Vischer, Henry F.
Publicado 2021

Bioluminescence Resonance Energy Transfer Based G Protein-Activation Assay to Probe Duration of Antagonism at the Histamine H(3) Receptor

por Mocking, Tamara A. M., Buzink, Maurice C. M. L., Leurs, Rob, Vischer, Henry F.
Publicado 2019

Short- and Long-Term Social Recognition Memory Are Differentially Modulated by Neuronal Histamine

por Rani, Barbara, Silva-Marques, Bruna, Leurs, Rob, Passani, Maria Beatrice, Blandina, Patrizio, Provensi, Gustavo
Publicado 2021

4-Hydroxypiperidines and Their Flexible 3-(Amino)propyloxy Analogues as Non-Imidazole Histamine H(3) Receptor Antagonist: Further Structure–Activity Relationship Exploration and In...

por Olszewska, Beata, Stasiak, Anna, McNaught Flores, Daniel, Fogel, Wiesława Agnieszka, Leurs, Rob, Walczyński, Krzysztof
Publicado 2018

Structure‐Activity Relationship of Phenylpyrazolones against Trypanosoma cruzi

por Sijm, Maarten, Sterk, Geert Jan, Caljon, Guy, Maes, Louis, de Esch, Iwan J. P., Leurs, Rob
Publicado 2020

Structure Activity Relationship of N-Substituted Phenyldihydropyrazolones Against Trypanosoma cruzi Amastigotes

por Sijm, Maarten, Maes, Louis, de Esch, Iwan J. P., Caljon, Guy, Sterk, Geert Jan, Leurs, Rob
Publicado 2021

Ubiquitination of CXCR7 Controls Receptor Trafficking

por Canals, Meritxell, Scholten, Danny J., de Munnik, Sabrina, Han, Mitchell K. L., Smit, Martine J., Leurs, Rob
Publicado 2012

Structural Analysis of Chemokine Receptor–Ligand Interactions

por Arimont, Marta, Sun, Shan-Liang, Leurs, Rob, Smit, Martine, de Esch, Iwan J. P., de Graaf, Chris
Publicado 2017

Non-Imidazole Histamine H(3) Ligands. Part VII. Synthesis, In Vitro and In Vivo Characterization of 5-Substituted-2-thiazol-4-n-propylpiperazines

por Guryn, Roman, Staszewski, Marek, Stasiak, Anna, McNaught Flores, Daniel, Fogel, Wiesława Agnieszka, Leurs, Rob, Walczyński, Krzysztof
Publicado 2018

The single cyclic nucleotide-specific phosphodiesterase of the intestinal parasite Giardia lamblia represents a potential drug target

por Kunz, Stefan, Balmer, Vreni, Sterk, Geert Jan, Pollastri, Michael P., Leurs, Rob, Müller, Norbert, Hemphill, Andrew, Spycher, Cornelia
Publicado 2017

Development of a Conformational Histamine H(3) Receptor Biosensor for the Synchronous Screening of Agonists and Inverse Agonists

por Schihada, Hannes, Ma, Xiaoyuan, Zabel, Ulrike, Vischer, Henry F., Schulte, Gunnar, Leurs, Rob, Pockes, Steffen, Lohse, Martin J.
Publicado 2020

The Target Residence Time of Antihistamines Determines Their Antagonism of the G Protein-Coupled Histamine H1 Receptor

por Bosma, Reggie, Witt, Gesa, Vaas, Lea A. I., Josimovic, Ivana, Gribbon, Philip, Vischer, Henry F., Gul, Sheraz, Leurs, Rob
Publicado 2017

PSW-Designer: An Open-Source Computational Platform for the Design and Virtual Screening of Photopharmacological Ligands

por Simon, Icaro A., Homan, Evert J., Wijtmans, Maikel, Sundström, Michael, Leurs, Rob, De Esch, Iwan J. P., Zarzycka, Barbara A.
Publicado 2023

Metabolic profiling of ligands for the chemokine receptor CXCR3 by liquid chromatography-mass spectrometry coupled to bioaffinity assessment

por Mladic, Marija, Scholten, Danny J., Wijtmans, Maikel, Falck, David, Leurs, Rob, Niessen, Wilfried M. A., Smit, Martine J., Kool, Jeroen
Publicado 2015

Function-specific virtual screening for GPCR ligands using a combined scoring method

por Kooistra, Albert J., Vischer, Henry F., McNaught-Flores, Daniel, Leurs, Rob, de Esch, Iwan J. P., de Graaf, Chris
Publicado 2016

KLIFS: a structural kinase-ligand interaction database

por Kooistra, Albert J., Kanev, Georgi K., van Linden, Oscar P.J., Leurs, Rob, de Esch, Iwan J.P., de Graaf, Chris
Publicado 2016