Structural and Spectroscopic Analysis of the Kinase Inhibitor Bosutinib and an Isomer of Bosutinib Binding to the Abl Tyrosine Kinase Domain

por Levinson, Nicholas M., Boxer, Steven G.
Publicado 2012

A conserved water-mediated hydrogen bond network defines bosutinib’s kinase selectivity

por Levinson, Nicholas M., Boxer, Steven G.
Publicado 2013

The Tyrosine Kinase Csk Dimerizes through Its SH3 Domain

por Levinson, Nicholas M., Visperas, Patrick R., Kuriyan, John
Publicado 2009

A Src-Like Inactive Conformation in the Abl Tyrosine Kinase Domain

por Levinson, Nicholas M, Kuchment, Olga, Shen, Kui, Young, Matthew A, Koldobskiy, Michael, Karplus, Martin, Cole, Philip A, Kuriyan, John
Publicado 2006

Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states

por Lake, Eric W., Muretta, Joseph M., Thompson, Andrew R., Rasmussen, Damien M., Majumdar, Abir, Faber, Erik B., Ruff, Emily F., Thomas, David D., Levinson, Nicholas M.
Publicado 2018

Allostery governs Cdk2 activation and differential recognition of CDK inhibitors

por Majumdar, Abir, Burban, David J., Muretta, Joseph M., Thompson, Andrew R., Engel, Tiffany A., Rasmussen, Damien M., Subrahmanian, Manu V., Veglia, Gianluigi, Thomas, David D., Levinson, Nicholas M.
Publicado 2021

A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation

por Ruff, Emily F, Muretta, Joseph M, Thompson, Andrew R, Lake, Eric W, Cyphers, Soreen, Albanese, Steven K, Hanson, Sonya M, Behr, Julie M, Thomas, David D, Chodera, John D, Levinson, Nicholas M
Publicado 2018

Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding

por Faber, Erik B., Sun, Luxin, Tang, Jian, Roberts, Emily, Ganeshkumar, Sornakala, Wang, Nan, Rasmussen, Damien, Majumdar, Abir, Hirsch, Laura E., John, Kristen, Yang, An, Khalid, Hira, Hawkinson, Jon E., Levinson, Nicholas M., Chennathukuzhi, Vargheese, Harki, Daniel A., Schönbrunn, Ernst, Georg, Gunda I.
Publicado 2023