Computational and structure-guided design of phosphoinositide substrate specificity into the tyrosine specific LMW-PTP enzyme

por Egbe, Eyong, Levy, Colin W., Tabernero, Lydia
Publicado 2020

Structure and Properties of a Natural Competence-Associated Pilin Suggest a Unique Pilus Tip-Associated DNA Receptor

por Salleh, Mohd Zulkifli, Karuppiah, Vijaykumar, Snee, Matthew, Thistlethwaite, Angela, Levy, Colin W., Knight, David, Derrick, Jeremy P.
Publicado 2019

Studies of the oligomerisation mechanism of a cystatin-based engineered protein scaffold

por Zalar, Matja, Indrakumar, Sowmya, Levy, Colin W., Tunnicliffe, Richard B., Peters, Günther H. J., Golovanov, Alexander P.
Publicado 2019

Better than Nature: Nicotinamide Biomimetics That Outperform Natural Coenzymes

por Knaus, Tanja, Paul, Caroline E., Levy, Colin W., de Vries, Simon, Mutti, Francesco G., Hollmann, Frank, Scrutton, Nigel S.
Publicado 2016

Biocatalytic Asymmetric Alkene Reduction: Crystal Structure and Characterization of a Double Bond Reductase from Nicotiana tabacum

por Mansell, David J., Toogood, Helen S., Waller, John, Hughes, John M. X., Levy, Colin W., Gardiner, John M., Scrutton, Nigel S.
Publicado 2013

The Dual PDZ Domain from Postsynaptic Density Protein 95 Forms a Scaffold with Peptide Ligand

por Rodzli, Nazahiyah A., Lockhart-Cairns, Michael P., Levy, Colin W., Chipperfield, John, Bird, Louise, Baldock, Clair, Prince, Stephen M.
Publicado 2020

How a 10-epi-Cubebol Synthase Avoids Premature Reaction Quenching to Form a Tricyclic Product at High Purity

por Whitehead, Joshua N., Leferink, Nicole G. H., Komati Reddy, Gajendar, Levy, Colin W., Hay, Sam, Takano, Eriko, Scrutton, Nigel S.
Publicado 2022

Structural and catalytic properties of the peroxygenase P450 enzyme CYP152K6 from Bacillus methanolicus

por Girvan, Hazel M., Poddar, Harshwardhan, McLean, Kirsty J., Nelson, David R., Hollywood, Katherine A., Levy, Colin W., Leys, David, Munro, Andrew W.
Publicado 2018

Utilization of dietary mixed-linkage β-glucans by the Firmicute Blautia producta

por Singh, Ravindra Pal, Niharika, Jayashree, Thakur, Raksha, Wagstaff, Ben A., Kumar, Gulshan, Kurata, Rikuya, Patel, Dhaval, Levy, Colin W., Miyazaki, Takatsugu, Field, Robert A.
Publicado 2023

Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs

por Jeffreys, Laura N., Poddar, Harshwardhan, Golovanova, Marina, Levy, Colin W., Girvan, Hazel M., McLean, Kirsty J., Voice, Michael W., Leys, David, Munro, Andrew W.
Publicado 2019

Equatorial Active Site Compaction and Electrostatic Reorganization in Catechol-O-methyltransferase

por Czarnota, Sylwia, Johannissen, Linus O., Baxter, Nicola J., Rummel, Felix, Wilson, Alex L., Cliff, Matthew J., Levy, Colin W., Scrutton, Nigel S., Waltho, Jonathan P., Hay, Sam
Publicado 2019

Catalytic Determinants of Alkene Production by the Cytochrome P450 Peroxygenase OleT(JE)

por Matthews, Sarah, Belcher, James D., Tee, Kang Lan, Girvan, Hazel M., McLean, Kirsty J., Rigby, Stephen E. J., Levy, Colin W., Leys, David, Parker, David A., Blankley, Richard T., Munro, Andrew W.
Publicado 2017

Structural characterization of CYP144A1 – a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis

por Chenge, Jude, Kavanagh, Madeline E., Driscoll, Max D., McLean, Kirsty J., Young, Douglas B., Cortes, Teresa, Matak-Vinkovic, Dijana, Levy, Colin W., Rigby, Stephen E. J., Leys, David, Abell, Chris, Munro, Andrew W.
Publicado 2016

Biocatalysis in Drug Design: Engineered Reductive Aminases (RedAms) Are Used to Access Chiral Building Blocks with Multiple Stereocenters

por Casamajo, Arnau Rué, Yu, Yuqi, Schnepel, Christian, Morrill, Charlotte, Barker, Rhys, Levy, Colin W., Finnigan, James, Spelling, Victor, Westerlund, Kristina, Petchey, Mark, Sheppard, Robert J., Lewis, Richard J., Falcioni, Francesco, Hayes, Martin A., Turner, Nicholas J.
Publicado 2023

Design and Synthesis of Imidazole and Triazole Pyrazoles as Mycobacterium Tuberculosis CYP121A1 Inhibitors

por Kishk, Safaa M., McLean, Kirsty J., Sood, Sakshi, Smith, Darren, Evans, Jack W.D., Helal, Mohamed A., Gomaa, Mohamed S., Salama, Ismail, Mostafa, Samia M., de Carvalho, Luiz Pedro S., Levy, Colin W., Munro, Andrew W., Simons, Claire
Publicado 2019

Redox driven B(12)-ligand switch drives CarH photoresponse

por Poddar, Harshwardhan, Rios-Santacruz, Ronald, Heyes, Derren J., Shanmugam, Muralidharan, Brookfield, Adam, Johannissen, Linus O., Levy, Colin W., Jeffreys, Laura N., Zhang, Shaowei, Sakuma, Michiyo, Colletier, Jacques-Philippe, Hay, Sam, Schirò, Giorgio, Weik, Martin, Scrutton, Nigel S., Leys, David
Publicado 2023

Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors

por Kavanagh, Madeline E., Coyne, Anthony G., McLean, Kirsty J., James, Guy G., Levy, Colin W., Marino, Leonardo B., de Carvalho, Luiz Pedro S., Chan, Daniel S. H., Hudson, Sean A., Surade, Sachin, Leys, David, Munro, Andrew W., Abell, Chris
Publicado 2016

Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation

por Taban, Ismail M., Elshihawy, Hosam E. A. E., Torun, Beyza, Zucchini, Benedetta, Williamson, Clare J., Altuwairigi, Dania, Ngu, Adeline S. T., McLean, Kirsty J., Levy, Colin W., Sood, Sakshi, Marino, Leonardo B., Munro, Andrew W., de Carvalho, Luiz Pedro S., Simons, Claire
Publicado 2017

Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1

por Chenge, Jude T., Duyet, Le Van, Swami, Shalini, McLean, Kirsty J., Kavanagh, Madeline E., Coyne, Anthony G., Rigby, Stephen E. J., Cheesman, Myles R., Girvan, Hazel M., Levy, Colin W., Rupp, Bernd, von Kries, Jens P., Abell, Chris, Leys, David, Munro, Andrew W.
Publicado 2017

A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening app...

por Frederickson, Martyn, Selvam, Irwin R., Evangelopoulos, Dimitrios, McLean, Kirsty J., Katariya, Mona M., Tunnicliffe, Richard B., Campbell, Bethany, Kavanagh, Madeline E., Charoensutthivarakul, Sitthivut, Blankley, Richard T., Levy, Colin W., de Carvalho, Luiz Pedro S., Leys, David, Munro, Andrew W., Coyne, Anthony G., Abell, Chris
Publicado 2022