DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity

por Ghosh, Arundhati Sengupta, Wang, Bei, Pozniak, Christine D., Chen, Mark, Watts, Ryan J., Lewcock, Joseph W.
Publicado 2011

JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis

por Huntwork-Rodriguez, Sarah, Wang, Bei, Watkins, Trent, Ghosh, Arundhati Sengupta, Pozniak, Christine D., Bustos, Daisy, Newton, Kim, Kirkpatrick, Donald S., Lewcock, Joseph W.
Publicado 2013

A Whole Cell Assay to Measure Caspase-6 Activity by Detecting Cleavage of Lamin A/C

por Mintzer, Robert, Ramaswamy, Sreemathy, Shah, Kinjalkumar, Hannoush, Rami N., Pozniak, Christine D., Cohen, Frederick, Zhao, Xianrui, Plise, Emile, Lewcock, Joseph W., Heise, Christopher E.
Publicado 2012

Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult

por Larhammar, Martin, Huntwork-Rodriguez, Sarah, Jiang, Zhiyu, Solanoy, Hilda, Sengupta Ghosh, Arundhati, Wang, Bei, Kaminker, Joshua S, Huang, Kevin, Eastham-Anderson, Jeffrey, Siu, Michael, Modrusan, Zora, Farley, Madeline M, Tessier-Lavigne, Marc, Lewcock, Joseph W, Watkins, Trent A
Publicado 2017

Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration

por Pozniak, Christine D., Sengupta Ghosh, Arundhati, Gogineni, Alvin, Hanson, Jesse E., Lee, Seung-Hye, Larson, Jessica L., Solanoy, Hilda, Bustos, Daisy, Li, Hong, Ngu, Hai, Jubb, Adrian M., Ayalon, Gai, Wu, Jiansheng, Scearce-Levie, Kimberly, Zhou, Qiang, Weimer, Robby M., Kirkpatrick, Donald S., Lewcock, Joseph W.
Publicado 2013

Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6

por Heise, Christopher E., Murray, Jeremy, Augustyn, Katherine E., Bravo, Brandon, Chugha, Preeti, Cohen, Frederick, Giannetti, Anthony M., Gibbons, Paul, Hannoush, Rami N., Hearn, Brian R., Jaishankar, Priyadarshini, Ly, Cuong Q., Shah, Kinjalkumar, Stanger, Karen, Steffek, Micah, Tang, Yinyan, Zhao, Xianrui, Lewcock, Joseph W., Renslo, Adam R., Flygare, John, Arkin, Michelle R.
Publicado 2012

Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain

por Newton, Kim, Dugger, Debra L., Sengupta-Ghosh, Arundhati, Ferrando, Ronald E., Chu, Felix, Tao, Janet, Lam, Wendy, Haller, Susan, Chan, Sara, Sa, Susan, Dunlap, Debra, Eastham-Anderson, Jeffrey, Ngu, Hai, Hung, Jeffrey, French, Dorothy M., Webster, Joshua D., Bolon, Brad, Liu, Jinfeng, Reja, Rohit, Kummerfeld, Sarah, Chen, Ying-Jiun, Modrusan, Zora, Lewcock, Joseph W., Dixit, Vishva M.
Publicado 2018

Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region

por Schlepckow, Kai, Monroe, Kathryn M, Kleinberger, Gernot, Cantuti‐Castelvetri, Ludovico, Parhizkar, Samira, Xia, Dan, Willem, Michael, Werner, Georg, Pettkus, Nadine, Brunner, Bettina, Sülzen, Alice, Nuscher, Brigitte, Hampel, Heike, Xiang, Xianyuan, Feederle, Regina, Tahirovic, Sabina, Park, Joshua I, Prorok, Rachel, Mahon, Cathal, Liang, Chun‐Chi, Shi, Ju, Kim, Do Jin, Sabelström, Hanna, Huang, Fen, Di Paolo, Gilbert, Simons, Mikael, Lewcock, Joseph W, Haass, Christian
Publicado 2020

Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency

por Reifschneider, Anika, Robinson, Sophie, van Lengerich, Bettina, Gnörich, Johannes, Logan, Todd, Heindl, Steffanie, Vogt, Miriam A, Weidinger, Endy, Riedl, Lina, Wind, Karin, Zatcepin, Artem, Pesämaa, Ida, Haberl, Sophie, Nuscher, Brigitte, Kleinberger, Gernot, Klimmt, Julien, Götzl, Julia K, Liesz, Arthur, Bürger, Katharina, Brendel, Matthias, Levin, Johannes, Diehl‐Schmid, Janine, Suh, Jung, Di Paolo, Gilbert, Lewcock, Joseph W, Monroe, Kathryn M, Paquet, Dominik, Capell, Anja, Haass, Christian
Publicado 2022

Molecular architecture determines brain delivery of a transferrin receptor–targeted lysosomal enzyme

por Arguello, Annie, Mahon, Cathal S., Calvert, Meredith E.K., Chan, Darren, Dugas, Jason C., Pizzo, Michelle E., Thomsen, Elliot R., Chau, Roni, Damo, Lorna A., Duque, Joseph, Fang, Meng, Giese, Tina, Kim, Do Jin, Liang, Nicholas, Nguyen, Hoang N., Solanoy, Hilda, Tsogtbaatar, Buyankhishig, Ullman, Julie C., Wang, Junhua, Dennis, Mark S., Diaz, Dolores, Gunasekaran, Kannan, Henne, Kirk R., Lewcock, Joseph W., Sanchez, Pascal E., Troyer, Matthew D., Harris, Jeffrey M., Scearce-Levie, Kimberly, Shan, Lu, Watts, Ryan J., Thorne, Robert G., Henry, Anastasia G., Kariolis, Mihalis S.
Publicado 2022

Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia

por Xia, Dan, Lianoglou, Steve, Sandmann, Thomas, Calvert, Meredith, Suh, Jung H., Thomsen, Elliot, Dugas, Jason, Pizzo, Michelle E., DeVos, Sarah L., Earr, Timothy K., Lin, Chia-Ching, Davis, Sonnet, Ha, Connie, Leung, Amy Wing-Sze, Nguyen, Hoang, Chau, Roni, Yulyaningsih, Ernie, Lopez, Isabel, Solanoy, Hilda, Masoud, Shababa T., Liang, Chun-chi, Lin, Karin, Astarita, Giuseppe, Khoury, Nathalie, Zuchero, Joy Yu, Thorne, Robert G., Shen, Kevin, Miller, Stephanie, Palop, Jorge J., Garceau, Dylan, Sasner, Michael, Whitesell, Jennifer D., Harris, Julie A., Hummel, Selina, Gnörich, Johannes, Wind, Karin, Kunze, Lea, Zatcepin, Artem, Brendel, Matthias, Willem, Michael, Haass, Christian, Barnett, Daniel, Zimmer, Till S., Orr, Anna G., Scearce-Levie, Kimberly, Lewcock, Joseph W., Di Paolo, Gilbert, Sanchez, Pascal E.
Publicado 2022

CD98hc is a target for brain delivery of biotherapeutics

por Chew, Kylie S., Wells, Robert C., Moshkforoush, Arash, Chan, Darren, Lechtenberg, Kendra J., Tran, Hai L., Chow, Johann, Kim, Do Jin, Robles-Colmenares, Yaneth, Srivastava, Devendra B., Tong, Raymond K., Tong, Mabel, Xa, Kaitlin, Yang, Alexander, Zhou, Yinhan, Akkapeddi, Padma, Annamalai, Lakshman, Bajc, Kaja, Blanchette, Marie, Cherf, Gerald Maxwell, Earr, Timothy K., Gill, Audrey, Huynh, David, Joy, David, Knight, Kristen N., Lac, Diana, Leung, Amy Wing-Sze, Lexa, Katrina W., Liau, Nicholas P. D., Becerra, Isabel, Malfavon, Mario, McInnes, Joseph, Nguyen, Hoang N., Lozano, Edwin I., Pizzo, Michelle E., Roche, Elysia, Sacayon, Patricia, Calvert, Meredith E. K., Daneman, Richard, Dennis, Mark S., Duque, Joseph, Gadkar, Kapil, Lewcock, Joseph W., Mahon, Cathal S., Meisner, René, Solanoy, Hilda, Thorne, Robert G., Watts, Ryan J., Zuchero, Y. Joy Yu, Kariolis, Mihalis S.
Publicado 2023

Author Correction: CD98hc is a target for brain delivery of biotherapeutics

por Chew, Kylie S., Wells, Robert C., Moshkforoush, Arash, Chan, Darren, Lechtenberg, Kendra J., Tran, Hai L., Chow, Johann, Kim, Do Jin, Robles-Colmenares, Yaneth, Srivastava, Devendra B., Tong, Raymond K., Tong, Mabel, Xa, Kaitlin, Yang, Alexander, Zhou, Yinhan, Akkapeddi, Padma, Annamalai, Lakshman, Bajc, Kaja, Blanchette, Marie, Cherf, Gerald Maxwell, Earr, Timothy K., Gill, Audrey, Huynh, David, Joy, David, Knight, Kristen N., Lac, Diana, Leung, Amy Wing-Sze, Lexa, Katrina W., Liau, Nicholas P. D., Becerra, Isabel, Malfavon, Mario, McInnes, Joseph, Nguyen, Hoang N., Lozano, Edwin I., Pizzo, Michelle E., Roche, Elysia, Sacayon, Patricia, Calvert, Meredith E. K., Daneman, Richard, Dennis, Mark S., Duque, Joseph, Gadkar, Kapil, Lewcock, Joseph W., Mahon, Cathal S., Meisner, René, Solanoy, Hilda, Thorne, Robert G., Watts, Ryan J., Zuchero, Y. Joy Yu, Kariolis, Mihalis S.
Publicado 2023

A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models

por van Lengerich, Bettina, Zhan, Lihong, Xia, Dan, Chan, Darren, Joy, David, Park, Joshua I., Tatarakis, David, Calvert, Meredith, Hummel, Selina, Lianoglou, Steve, Pizzo, Michelle E., Prorok, Rachel, Thomsen, Elliot, Bartos, Laura M., Beumers, Philipp, Capell, Anja, Davis, Sonnet S., de Weerd, Lis, Dugas, Jason C., Duque, Joseph, Earr, Timothy, Gadkar, Kapil, Giese, Tina, Gill, Audrey, Gnörich, Johannes, Ha, Connie, Kannuswamy, Malavika, Kim, Do Jin, Kunte, Sebastian T., Kunze, Lea H., Lac, Diana, Lechtenberg, Kendra, Leung, Amy Wing-Sze, Liang, Chun-Chi, Lopez, Isabel, McQuade, Paul, Modi, Anuja, Torres, Vanessa O., Nguyen, Hoang N., Pesämaa, Ida, Propson, Nicholas, Reich, Marvin, Robles-Colmenares, Yaneth, Schlepckow, Kai, Slemann, Luna, Solanoy, Hilda, Suh, Jung H., Thorne, Robert G., Vieira, Chandler, Wind-Mark, Karin, Xiong, Ken, Zuchero, Y. Joy Yu, Diaz, Dolo, Dennis, Mark S., Huang, Fen, Scearce-Levie, Kimberly, Watts, Ryan J., Haass, Christian, Lewcock, Joseph W., Di Paolo, Gilbert, Brendel, Matthias, Sanchez, Pascal E., Monroe, Kathryn M.
Publicado 2023