Therapeutic Potential of Protein Tyrosine Kinase 6 in Colorectal Cancer

por Jerin, Samanta, Harvey, Amanda J., Lewis, Annabelle
Publicado 2023

Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines

por Davis, Hayley, Lewis, Annabelle, Behrens, Axel, Tomlinson, Ian
Publicado 2014

FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development

por Davis, Hayley, Lewis, Annabelle, Spencer-Dene, Bradley, Tateossian, Hilda, Stamp, Gordon, Behrens, Axel, Tomlinson, Ian
Publicado 2011

NRF2 Mediates Therapeutic Resistance to Chemoradiation in Colorectal Cancer through a Metabolic Switch

por O’Cathail, Séan M., Wu, Chieh-Hsi, Thomas, Rachael, Hawkins, Maria A., Maughan, Tim S., Lewis, Annabelle
Publicado 2021

CRISPR-Cas9 Causes Chromosomal Instability and Rearrangements in Cancer Cell Lines, Detectable by Cytogenetic Methods

por Rayner, Emily, Durin, Mary-Anne, Thomas, Rachael, Moralli, Daniela, O'Cathail, Sean M., Tomlinson, Ian, Green, Catherine M., Lewis, Annabelle
Publicado 2019

Severe polyposis in Apc(1322T) mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5

por Lewis, Annabelle, Segditsas, Stefania, Deheragoda, Maesha, Pollard, Patrick, Jeffery, Rosemary, Nye, Emma, Lockstone, Helen, Davis, Hayley, Clark, Susan, Stamp, Gordon, Poulsom, Richard, Wright, Nicholas, Tomlinson, Ian
Publicado 2010

Hereditary mixed polyposis syndrome is caused by a 40kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1

por Jaeger, Emma, Leedham, Simon, Lewis, Annabelle, Segditsas, Stefania, Becker, Martin, Cuadrado, Pedro Rodenas, Davis, Hayley, Kaur, Kulvinder, Heinimann, Karl, Howarth, Kimberley, East, James, Taylor, Jenny, Thomas, Huw, Tomlinson, Ian
Publicado 2012

Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis

por Brown, Matthew, Leon, Alicia, Kedzierska, Katarzyna, Moore, Charlotte, Belnoue‐Davis, Hayley L, Flach, Susanne, Lydon, John P, DeMayo, Francesco J, Lewis, Annabelle, Bosse, Tjalling, Tomlinson, Ian, Church, David N
Publicado 2023

The polymorphic variant rs1800734 influences methylation acquisition and allele-specific TFAP4 binding in the MLH1 promoter leading to differential mRNA expression

por Thomas, Rachael, Trapani, Davide, Goodyer-Sait, Lily, Tomkova, Marketa, Fernandez-Rozadilla, Ceres, Sahnane, Nora, Woolley, Connor, Davis, Hayley, Chegwidden, Laura, Kriaucionis, Skirmantas, Maughan, Timothy, Leedham, Simon, Palles, Claire, Furlan, Daniela, Tomlinson, Ian, Lewis, Annabelle
Publicado 2019

FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation

por Babaei-Jadidi, Roya, Li, Ningning, Saadeddin, Anas, Spencer-Dene, Bradley, Jandke, Anett, Muhammad, Belal, Ibrahim, ElSayed E., Muraleedharan, Ranjithmenon, Abuzinadah, Mohammed, Davis, Hayley, Lewis, Annabelle, Watson, Susan, Behrens, Axel, Tomlinson, Ian, Nateri, Abdolrahman Shams
Publicado 2011

The MLH1 polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability

por Russell, Holly, Kedzierska, Katarzyna, Buchanan, Daniel D., Thomas, Rachael, Tham, Emma, Mints, Miriam, Keränen, Anne, Giles, Graham G., Southey, Melissa C., Milne, Roger L., Tomlinson, Ian, Church, David, Spurdle, Amanda B., O’Mara, Tracy A., Lewis, Annabelle
Publicado 2020

Correction to: The MLH1 polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability

por Russell, Holly, Kedzierska, Katarzyna, Buchanan, Daniel D., Thomas, Rachael, Tham, Emma, Mints, Miriam, Keränen, Anne, Giles, Graham G., Southey, Melissa C., Milne, Roger L., Tomlinson, Ian, Church, David, Spurdle, Amanda B., O’Mara, Tracy A., Lewis, Annabelle
Publicado 2021

A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts

por Leedham, Simon J, Rodenas-Cuadrado, Pedro, Howarth, Kimberley, Lewis, Annabelle, Mallappa, Sreelakshmi, Segditsas, Stefania, Davis, Hayley, Jeffery, Rosemary, Rodriguez-Justo, Manuel, Keshav, Satish, Travis, Simon P L, Graham, Trevor A, East, James, Clark, Susan, Tomlinson, Ian P M
Publicado 2013

Bone morphogenetic protein and Notch signalling crosstalk in poor‐prognosis, mesenchymal‐subtype colorectal cancer

por Irshad, Shazia, Bansal, Mukesh, Guarnieri, Paolo, Davis, Hayley, Al Haj Zen, Ayman, Baran, Brygida, Pinna, Claudia Maria Assunta, Rahman, Haseeb, Biswas, Sujata, Bardella, Chiara, Jeffery, Rosemary, Wang, Lai Mun, East, James Edward, Tomlinson, Ian, Lewis, Annabelle, Leedham, Simon John
Publicado 2017

A Polymorphic Enhancer near GREM1 Influences Bowel Cancer Risk through Differential CDX2 and TCF7L2 Binding

por Lewis, Annabelle, Freeman-Mills, Luke, de la Calle-Mustienes, Elisa, Giráldez-Pérez, Rosa María, Davis, Hayley, Jaeger, Emma, Becker, Martin, Hubner, Nina C., Nguyen, Luan N., Zeron-Medina, Jorge, Bond, Gareth, Stunnenberg, Hendrik G., Carvajal, Jaime J., Gomez-Skarmeta, Jose Luis, Leedham, Simon, Tomlinson, Ian
Publicado 2014

Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution

por Baker, Ann-Marie, Huang, Weini, Wang, Xiao-Ming Mindy, Jansen, Marnix, Ma, Xiao-Jun, Kim, Jeffrey, Anderson, Courtney M., Wu, Xingyong, Pan, Liuliu, Su, Nan, Luo, Yuling, Domingo, Enric, Heide, Timon, Sottoriva, Andrea, Lewis, Annabelle, Beggs, Andrew D., Wright, Nicholas A., Rodriguez-Justo, Manuel, Park, Emily, Tomlinson, Ian, Graham, Trevor A.
Publicado 2017

Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside of the crypt base stem cell niche

por Davis, Hayley, Irshad, Shazia, Bansal, Mukesh, Rafferty, Hannah, Boitsova, Tatjana, Bardella, Chiara, Jaeger, Emma, Lewis, Annabelle, Freeman-Mills, Luke, Giner, Francesc Castro, Rodenas-Cuadrado, Pedro, Mallappa, Sreelakshmi, Clark, Susan, Thomas, Huw, Jeffery, Rosemary, Poulsom, Richard, Rodriguez-Justo, Manuel, Novelli, Marco, Chetty, Runjan, Silver, Andrew, Sansom, Owen James, Greten, Florian R, Wang, Lai Mun, East, James Edward, Tomlinson, Ian, Leedham, Simon John
Publicado 2014

Multiple Common Susceptibility Variants near BMP Pathway Loci GREM1, BMP4, and BMP2 Explain Part of the Missing Heritability of Colorectal Cancer

por Tomlinson, Ian P. M., Carvajal-Carmona, Luis G., Dobbins, Sara E., Tenesa, Albert, Jones, Angela M., Howarth, Kimberley, Palles, Claire, Broderick, Peter, Jaeger, Emma E. M., Farrington, Susan, Lewis, Annabelle, Prendergast, James G. D., Pittman, Alan M., Theodoratou, Evropi, Olver, Bianca, Walker, Marion, Penegar, Steven, Barclay, Ella, Whiffin, Nicola, Martin, Lynn, Ballereau, Stephane, Lloyd, Amy, Gorman, Maggie, Lubbe, Steven, Howie, Bryan, Marchini, Jonathan, Ruiz-Ponte, Clara, Fernandez-Rozadilla, Ceres, Castells, Antoni, Carracedo, Angel, Castellvi-Bel, Sergi, Duggan, David, Conti, David, Cazier, Jean-Baptiste, Campbell, Harry, Sieber, Oliver, Lipton, Lara, Gibbs, Peter, Martin, Nicholas G., Montgomery, Grant W., Young, Joanne, Baird, Paul N., Gallinger, Steven, Newcomb, Polly, Hopper, John, Jenkins, Mark A., Aaltonen, Lauri A., Kerr, David J., Cheadle, Jeremy, Pharoah, Paul, Casey, Graham, Houlston, Richard S., Dunlop, Malcolm G.
Publicado 2011

Five endometrial cancer risk loci identified through genome-wide association analysis

por Cheng, Timothy HT, Thompson, Deborah J, O’Mara, Tracy A, Painter, Jodie N, Glubb, Dylan M, Flach, Susanne, Lewis, Annabelle, French, Juliet D, Freeman-Mills, Luke, Church, David, Gorman, Maggie, Martin, Lynn, Hodgson, Shirley, Webb, Penelope M, Attia, John, Holliday, Elizabeth G, McEvoy, Mark, Scott, Rodney J, Henders, Anjali K, Martin, Nicholas G, Montgomery, Grant W, Nyholt, Dale R, Ahmed, Shahana, Healey, Catherine S, Shah, Mitul, Dennis, Joe, Fasching, Peter A, Beckmann, Matthias W, Hein, Alexander, Ekici, Arif B, Hall, Per, Czene, Kamila, Darabi, Hatef, Li, Jingmei, Dörk, Thilo, Dürst, Matthias, Hillemanns, Peter, Runnebaum, Ingo, Amant, Frederic, Schrauwen, Stefanie, Zhao, Hui, Lambrechts, Diether, Depreeuw, Jeroen, Dowdy, Sean C, Goode, Ellen L, Fridley, Brooke L, Winham, Stacey J, Njølstad, Tormund S, Salvesen, Helga B, Trovik, Jone, Werner, Henrica MJ, Ashton, Katie, Otton, Geoffrey, Proietto, Tony, Liu, Tao, Mints, Miriam, Tham, Emma, Consortium, CHIBCHA, Jun Li, Mulin, Yip, Shun H, Wang, Junwen, Bolla, Manjeet K, Michailidou, Kyriaki, Wang, Qin, Tyrer, Jonathan P, Dunlop, Malcolm, Houlston, Richard, Palles, Claire, Hopper, John L, Peto, Julian, Swerdlow, Anthony J, Burwinkel, Barbara, Brenner, Hermann, Meindl, Alfons, Brauch, Hiltrud, Lindblom, Annika, Chang-Claude, Jenny, Couch, Fergus J, Giles, Graham G, Kristensen, Vessela N, Cox, Angela, Cunningham, Julie M, Pharoah, Paul D P, Dunning, Alison M, Edwards, Stacey L, Easton, Douglas F, Tomlinson, Ian, Spurdle, Amanda B
Publicado 2016