Inpatient Rehabilitation Issues Related to COVID-19

por Kelly, Amanda A., Lewis, Caroline A., Escalon, Miguel X.
Publicado 2023

Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading

por Jain, Nimansha, Lewis, Caroline A., Ulrich, Jason D., Holtzman, David M.
Publicado 2022

Identifying Cell-Type-Specific Metabolic Signatures Using Transcriptome and Proteome Analyses

por Gebert, Nadja, Rahman, Shahadat, Lewis, Caroline A., Ori, Alessandro, Cheng, Chia-Wei
Publicado 2021

Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition

por Muir, Alexander, Danai, Laura V, Gui, Dan Y, Waingarten, Chiara Y, Lewis, Caroline A, Vander Heiden, Matthew G
Publicado 2017

Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma

por Dayton, Talya L., Gocheva, Vasilena, Miller, Kathryn M., Bhutkar, Arjun, Lewis, Caroline A., Bronson, Roderick T., Vander Heiden, Matthew G., Jacks, Tyler
Publicado 2018

MFSD12 mediates the import of cysteine into melanosomes and lysosomes

por Adelmann, Charles H., Traunbauer, Anna K., Chen, Brandon, Condon, Kendall J., Chan, Sze Ham, Kunchok, Tenzin, Lewis, Caroline A., Sabatini, David M.
Publicado 2020

Dihydroxyacetone phosphate signals glucose availability to mTORC1

por Orozco, Jose M., Krawczyk, Patrycja A., Scaria, Sonia M., Cangelosi, Andrew L., Chan, Sze Ham, Kunchok, Tenzin, Lewis, Caroline A., Sabatini, David M.
Publicado 2020

Nucleotide imbalance decouples cell growth from cell proliferation

por Diehl, Frances F., Miettinen, Teemu P., Elbashir, Ryan, Nabel, Christopher S., Darnell, Alicia M., Do, Brian T., Manalis, Scott R., Lewis, Caroline A., Vander Heiden, Matthew G.
Publicado 2022

Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

por Sullivan, Mark R, Danai, Laura V, Lewis, Caroline A, Chan, Sze Ham, Gui, Dan Y, Kunchok, Tenzin, Dennstedt, Emily A, Vander Heiden, Matthew G, Muir, Alexander
Publicado 2019

Histidine catabolism is a major determinant of methotrexate sensitivity

por Kanarek, Naama, Keys, Heather R., Cantor, Jason R., Lewis, Caroline A., Chan, Sze Ham, Kunchok, Tenzin, Abu-Remaileh, Monther, Freinkman, Elizaveta, Schweitzer, Lawrence D., Sabatini, David M.
Publicado 2018

Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth

por Griffiths, Beatrice, Lewis, Caroline A, Bensaad, Karim, Ros, Susana, Zhang, Qifeng, Ferber, Emma C, Konisti, Sofia, Peck, Barrie, Miess, Heike, East, Philip, Wakelam, Michael, Harris, Adrian L, Schulze, Almut
Publicado 2013

Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumors

por Garcia-Bermudez, Javier, Baudrier, Lou, La, Konnor, Zhu, Xiphias Ge, Fidelin, Justine, Sviderskiy, Vladislav O, Papagiannakopoulos, Thales, Molina, Henrik, Snuderl, Matija, Lewis, Caroline A., Possemato, Richard L., Birsoy, Kıvanç
Publicado 2018

S-adenosylmethionine synthases specify distinct H3K4me3 populations and gene expression patterns during heat stress

por Godbole, Adwait A, Gopalan, Sneha, Nguyen, Thien-Kim, Munden, Alexander L, Lui, Dominique S, Fanelli, Matthew J, Vo, Paula, Lewis, Caroline A, Spinelli, Jessica B, Fazzio, Thomas G, Walker, Amy K
Publicado 2023

Aspartate is an endogenous metabolic limitation for tumour growth

por Sullivan, Lucas B., Luengo, Alba, Danai, Laura V., Bush, Lauren N., Diehl, Frances F., Hosios, Aaron M., Lau, Allison N., Elmiligy, Sarah, Malstrom, Scott, Lewis, Caroline A., Vander Heiden, Matthew G.
Publicado 2018

MCART1/SLC25A51 is required for mitochondrial NAD transport

por Kory, Nora, uit de Bos, Jelmi, van der Rijt, Sanne, Jankovic, Nevena, Güra, Miriam, Arp, Nicholas, Pena, Izabella A., Prakash, Gyan, Chan, Sze Ham, Kunchok, Tenzin, Lewis, Caroline A., Sabatini, David M.
Publicado 2020

High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity

por Mana, Miyeko D., Hussey, Amanda M., Tzouanas, Constantine N., Imada, Shinya, Millan, Yesenia Barrera, Bahceci, Dorukhan, Saiz, Dominic R., Webb, Anna T., Lewis, Caroline A., Carmeliet, Peter, Mihaylova, Maria M., Shalek, Alex K., Yilmaz, Ömer H.
Publicado 2021

Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer

por Luengo, Alba, Abbott, Keene L., Davidson, Shawn M., Hosios, Aaron M., Faubert, Brandon, Chan, Sze Ham, Freinkman, Elizaveta, Zacharias, Lauren G., Mathews, Thomas P., Clish, Clary B., DeBerardinis, Ralph J., Lewis, Caroline A., Vander Heiden, Matthew G.
Publicado 2019

Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy

por Pikman, Yana, Ocasio-Martinez, Nicole, Alexe, Gabriela, Dimitrov, Boris, Kitara, Samuel, Diehl, Frances F., Robichaud, Amanda L., Conway, Amy Saur, Ross, Linda, Su, Angela, Ling, Frank, Qi, Jun, Roti, Giovanni, Lewis, Caroline A., Puissant, Alexandre, Vander Heiden, Matthew G., Stegmaier, Kimberly
Publicado 2021

Targeting MTHFD2 in acute myeloid leukemia

por Pikman, Yana, Puissant, Alexandre, Alexe, Gabriela, Furman, Andrew, Chen, Liying M., Frumm, Stacey M., Ross, Linda, Fenouille, Nina, Bassil, Christopher F., Lewis, Caroline A., Ramos, Azucena, Gould, Joshua, Stone, Richard M., DeAngelo, Daniel J., Galinsky, Ilene, Clish, Clary B., Kung, Andrew L., Hemann, Michael T., Vander Heiden, Matthew G., Banerji, Versha, Stegmaier, Kimberly
Publicado 2016

A unique subset of glycolytic tumor propagating cells drives squamous cell carcinoma

por Choi, Jee-Eun, Sebastian, Carlos, Ferrer, Christina M., Lewis, Caroline A., Sade-Feldman, Moshe, LaSalle, Thomas, Gonye, Anna, Lopez, Begona G. C., Abdelmoula, Walid M., Regan, Michael S., Cetinbas, Murat, Pascual, Gloria, Wojtkiewicz, Gregory R., Silveira, Giorgia G., Boon, Ruben, Ross, Kenneth N., Tirosh, Itay, Saladi, Srinivas V., Ellisen, Leif W., Sadreyev, Ruslan I., Benitah, Salvador Aznar, Agar, Nathalie Y. R., Hacohen, Nir, Mostoslavsky, Raul
Publicado 2021