Discovery of novel and potent P2Y(14)R antagonists via structure-based virtual screening for the treatment of acute gouty arthritis

por Wang, Weiwei, Liu, Chunxiao, Li, Hanwen, Tian, Sheng, Liu, Yingxian, Wang, Nanxi, Yan, Duanyang, Li, Huanqiu, Hu, Qinghua
Publicado 2020

GPR105-Targeted Therapy Promotes Gout Resolution as a Switch Between NETosis and Apoptosis of Neutrophils

por Liu, Chunxiao, Zhou, Mengze, Jiang, Wenjiao, Ye, Shumin, Tian, Sheng, Jiang, Cheng, Hao, Kun, Li, Huanqiu, Hu, Qinghua
Publicado 2022

A novel SRSF3 inhibitor, SFI003, exerts anticancer activity against colorectal cancer by modulating the SRSF3/DHCR24/ROS axis

por Zhang, Yawen, Wang, Mengmeng, Meng, Fanyi, Yang, Man, Chen, Yinshuang, Guo, Xuqin, Wang, Weiwei, Zhu, Yifan, Guo, Yundi, Feng, Chunlai, Tian, Shen, Zhang, Hongjian, Li, Huanqiu, Sun, Jing, Wang, Weipeng
Publicado 2022

FDW028, a novel FUT8 inhibitor, impels lysosomal proteolysis of B7-H3 via chaperone-mediated autophagy pathway and exhibits potent efficacy against metastatic colorectal cancer

por Wang, Mengmeng, Zhang, Zhoudong, Chen, Mengxi, Lv, Yixin, Tian, Sheng, Meng, Fanyi, Zhang, Yawen, Guo, Xuqin, Chen, Yinshuang, Yang, Man, Li, Jiawei, Qiu, Tian, Xu, Fang, Li, Zhi, Zhang, Qi, Yang, Jie, Sun, Jing, Zhang, Hongjian, Zhang, Haiyang, Li, Huanqiu, Wang, Weipeng
Publicado 2023