A mechanistic kinetic description of lactate dehydrogenase elucidating cancer diagnosis and inhibitor evaluation

por Tang, Peifeng, Xu, Jianlin, Oliveira, Christopher L., Li, Zheng Jian, Liu, Shijie
Publicado 2017

Computational insights into O-glycosylation in a CTLA4 Fc-fusion protein linker and its impact on protein quality attributes

por Song, Yuanli, Qian, Yueming, Huang, Zhe, Khattak, Sarwat F., Li, Zheng Jian
Publicado 2020

Design of next-generation therapeutic IgG4 with improved manufacturability and bioanalytical characteristics

por Chen, Zhiqiang, Qian, Yueming, Song, Yuanli, Xu, Xuankuo, Tao, Li, Mussa, Nesredin, Ghose, Sanchayita, Li, Zheng Jian
Publicado 2020

N-1 Perfusion Platform Development Using a Capacitance Probe for Biomanufacturing

por Rittershaus, Emily S. C., Rehmann, Matthew S., Xu, Jianlin, He, Qin, Hill, Charles, Swanberg, Jeffrey, Borys, Michael C., Li, Zheng-Jian, Khetan, Anurag
Publicado 2022

High throughput screening data for a case study of CHO cell culture process development

por He, Qin, Xu, Jianlin, Vandermark, Erik, Tian, Jun, Qian, Yueming, Chelius, Cynthia, Lee, Jongchan, Borys, Michael C., Li, Zheng Jian, Pendse, Girish
Publicado 2021

Optimization and kinetic modeling of interchain disulfide bond reoxidation of monoclonal antibodies in bioprocesses

por Tang, Peifeng, Tan, Zhijun, Ehamparanathan, Vivekh, Ren, Tingwei, Hoffman, Laurel, Du, Cheng, Song, Yuanli, Tao, Li, Lewandowski, Angela, Ghose, Sanchayita, Li, Zheng Jian, Liu, Shijie
Publicado 2020

Biomanufacturing evolution from conventional to intensified processes for productivity improvement: a case study

por Xu, Jianlin, Xu, Xuankuo, Huang, Chao, Angelo, James, Oliveira, Christopher L., Xu, Mengmeng, Xu, Xia, Temel, Deniz, Ding, Julia, Ghose, Sanchayita, Borys, Michael C., Li, Zheng Jian
Publicado 2020

Increased MSX level improves biological productivity and production stability in multiple recombinant GS CHO cell lines

por Tian, Jun, He, Qin, Oliveira, Christopher, Qian, Yueming, Egan, Susan, Xu, Jianlin, Qian, Nan‐Xin, Langsdorf, Erik, Warrack, Bethanne, Aranibar, Nelly, Reily, Michael, Borys, Michael, Li, Zheng Jian
Publicado 2020

Understanding and Controlling Sialylation in a CHO Fc-Fusion Process

por Lewis, Amanda M., Croughan, William D., Aranibar, Nelly, Lee, Alison G., Warrack, Bethanne, Abu-Absi, Nicholas R., Patel, Rutva, Drew, Barry, Borys, Michael C., Reily, Michael D., Li, Zheng Jian
Publicado 2016

On-column disulfide bond formation of monoclonal antibodies during Protein A chromatography eliminates low molecular weight species and rescues reduced antibodies

por Tan, Zhijun, Ehamparanathan, Vivekh, Ren, Tingwei, Tang, Peifeng, Hoffman, Laurel, Kuang, June, Liu, Peiran, Huang, Chao, Du, Cheng, Tao, Li, Chemmalil, Letha, Lewandowski, Angela, Ghose, Sanchayita, Li, Zheng Jian, Liu, Shijie
Publicado 2020

Metabolomic and quality data for early and late passages of an antibody-producing industrial CHO cell line

por Sowa, Steven W., Qian, Yueming, Aron, Kathryn L., Xu, Ping, Langsdorf, Erik, Warrack, Bethanne, Aranibar, Nelly, Tremml, Gabi, Xu, Jianlin, McVey, Duncan, Reily, Michael, Khetan, Anurag, Borys, Michael C., Li, Zheng Jian
Publicado 2020

Improved Titer in Late-Stage Mammalian Cell Culture Manufacturing by Re-Cloning

por He, Qin, Rehmann, Matthew S., Tian, Jun, Xu, Jianlin, Sabino, Luzmary, Vandermark, Erik, Basson, Ziev, Po, Iris, Bierilo, Kathleen, Tremml, Gabi, Rizzi, Giovanni, Langsdorf, Erik F., Qian, Nan-Xin, Borys, Michael C., Khetan, Anurag, Li, Zheng-Jian
Publicado 2022