Tau and TDP-43 synergy: a novel therapeutic target for sporadic late-onset Alzheimer’s disease

por Latimer, Caitlin S., Liachko, Nicole F.
Publicado 2021

sut-2 loss of function mutants protect against tau-driven shortened lifespan and hyperactive pharyngeal pumping in a C. elegans model of tau toxicity

por Currey, Heather N, Kraemer, Brian C., Liachko, Nicole F
Publicado 2023

Regulation of TDP-43 phosphorylation in aging and disease

por Eck, Randall J., Kraemer, Brian C., Liachko, Nicole F.
Publicado 2021

ARENA-based activity profiling of tau and TDP-43 transgenic C. elegans

por Currey, Heather N, Malinkevich, Anna, Melquist, Penny, Liachko, Nicole F
Publicado 2020

Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau

por Waldherr, Sarah M., Strovas, Timothy J., Vadset, Taylor A., Liachko, Nicole F., Kraemer, Brian C.
Publicado 2019

SPOP loss of function protects against tauopathy

por Eck, Randall J., Kow, Rebecca L., Black, Aristide H., Liachko, Nicole F., Kraemer, Brian C.
Publicado 2022

Cytochrome P450 and Epoxide Hydrolase Metabolites in Aβ and tau-induced Neurodegeneration: Insights from Caenorhabditis elegans

por Sarparast, Morteza, Hinman, Jennifer, Pourmand, Elham, Vonarx, Derek, Ramirez, Leslie, Ma, Wenjuan, Liachko, Nicole F., Alan, Jamie K., Lee, Kin Sing Stephen
Publicado 2023

Genome wide analysis reveals heparan sulfate epimerase modulates TDP-43 proteinopathy

por Liachko, Nicole F., Saxton, Aleen D., McMillan, Pamela J., Strovas, Timothy J., Keene, C. Dirk, Bird, Thomas D., Kraemer, Brian C.
Publicado 2019

TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic Caenorhabditis elegans

por Latimer, Caitlin S., Stair, Jade G., Hincks, Joshua C., Currey, Heather N., Bird, Thomas D., Keene, C. Dirk, Kraemer, Brian C., Liachko, Nicole F.
Publicado 2022

Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration

por Taylor, Laura M., McMillan, Pamela J., Liachko, Nicole F., Strovas, Timothy J., Ghetti, Bernardino, Bird, Thomas D., Keene, C. Dirk, Kraemer, Brian C.
Publicado 2018

Protein Kinase CK-1 Inhibitors As New Potential Drugs for Amyotrophic Lateral Sclerosis

por Salado, Irene G., Redondo, Miriam, Bello, Murilo L., Perez, Concepción, Liachko, Nicole F., Kraemer, Brian C., Miguel, Laetitia, Lecourtois, Magalie, Gil, Carmen, Martinez, Ana, Perez, Daniel I.
Publicado 2014

Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice

por McMillan, Pamela, Wheeler, Jeanna, Gatlin, Rachel E., Taylor, Laura, Strovas, Tim, Baum, Misa, Bird, Thomas D., Latimer, Caitlin, Keene, C. Dirk, Kraemer, Brian C., Liachko, Nicole F.
Publicado 2020

The Tau Tubulin Kinases TTBK1/2 Promote Accumulation of Pathological TDP-43

por Liachko, Nicole F., McMillan, Pamela J., Strovas, Timothy J., Loomis, Elaine, Greenup, Lynne, Murrell, Jill R., Ghetti, Bernardino, Raskind, Murray A., Montine, Thomas J., Bird, Thomas D., Leverenz, James B., Kraemer, Brian C.
Publicado 2014

Sertraline, Paroxetine, and Chlorpromazine Are Rapidly Acting Anthelmintic Drugs Capable of Clinical Repurposing

por Weeks, Janis C., Roberts, William M., Leasure, Caitlyn, Suzuki, Brian M., Robinson, Kristin J., Currey, Heather, Wangchuk, Phurpa, Eichenberger, Ramon M., Saxton, Aleen D., Bird, Thomas D., Kraemer, Brian C., Loukas, Alex, Hawdon, John M., Caffrey, Conor R., Liachko, Nicole F.
Publicado 2018

Resistance and resilience to Alzheimer’s disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a commun...

por Latimer, Caitlin S., Burke, Bridget T., Liachko, Nicole F., Currey, Heather N., Kilgore, Mitchell D., Gibbons, Laura E., Henriksen, Jonathan, Darvas, Martin, Domoto-Reilly, Kimiko, Jayadev, Suman, Grabowski, Tom J., Crane, Paul K., Larson, Eric B., Kraemer, Brian C., Bird, Thomas D., Keene, C. Dirk
Publicado 2019