Targeting Mitochondrial Dysfunction and Oxidative Stress in Activated Microglia using Dendrimer-Based Therapeutics

por Sharma, Anjali, Liaw, Kevin, Sharma, Rishi, Zhang, Zhi, Kannan, Sujatha, Kannan, Rangaramanujam M.
Publicado 2018

Dendrimer size effects on the selective brain tumor targeting in orthotopic tumor models upon systemic administration

por Liaw, Kevin, Zhang, Fan, Mangraviti, Antonella, Kannan, Sujatha, Tyler, Betty, Kannan, Rangaramanujam M.
Publicado 2020

Targeted systemic dendrimer delivery of CSF‐1R inhibitor to tumor‐associated macrophages improves outcomes in orthotopic glioblastoma

por Liaw, Kevin, Reddy, Rajsekhar, Sharma, Anjali, Li, Jiangyu, Chang, Michelle, Sharma, Rishi, Salazar, Sebastian, Kannan, Sujatha, Kannan, Rangaramanujam M.
Publicado 2020

In vivo DNA-launched bispecific T cell engager targeting IL-13Rα2 controls tumor growth in an animal model of glioblastoma multiforme

por Bhojnagarwala, Pratik S., O’Connell, Ryan P., Park, Daniel, Liaw, Kevin, Ali, Ali R., Bordoloi, Devivasha, Cassel, Joel, Tursi, Nicholas J., Gary, Ebony, Weiner, David B.
Publicado 2022

Dense hydroxyl polyethylene glycol dendrimer targets activated glia in multiple CNS disorders

por Sharma, Anjali, Sharma, Rishi, Zhang, Zhi, Liaw, Kevin, Kambhampati, Siva P., Porterfield, Joshua E., Lin, Ku Chien, DeRidder, Louis B., Kannan, Sujatha, Kannan, Rangaramanujam M.
Publicado 2020

A mAb against surface-expressed FSHR engineered to engage adaptive immunity for ovarian cancer immunotherapy

por Bordoloi, Devivasha, Bhojnagarwala, Pratik S., Perales-Puchalt, Alfredo, Kulkarni, Abhijeet J., Zhu, Xizhou, Liaw, Kevin, O’Connell, Ryan P., Park, Daniel H., Kulp, Daniel W., Zhang, Rugang, Weiner, David B.
Publicado 2022

DNA immunotherapy targeting BARF1 induces potent anti-tumor responses against Epstein-Barr-virus-associated carcinomas

por Zhu, Xizhou, Perales-Puchalt, Alfredo, Wojtak, Krzysztof, Xu, Ziyang, Yun, Kun, Bhojnagarwala, Pratik S., Bordoloi, Devivasha, Park, Daniel H., Liaw, Kevin, Bah, Mamadou A., Lieberman, Paul M., Gary, Ebony N., Patel, Ami, Weiner, David B.
Publicado 2021

Dendrimer-2PMPA selectively blocks upregulated microglial GCPII activity and improves cognition in a mouse model of multiple sclerosis

por Hollinger, Kristen R., Sharma, Anjali, Tallon, Carolyn, Lovell, Lyndah, Thomas, Ajit G., Zhu, Xiaolei, Wiseman, Robyn, Wu, Ying, Kambhampati, Siva P., Liaw, Kevin, Sharma, Rishi, Rojas, Camilo, Rais, Rana, Kannan, Sujatha, Kannan, Rangaramanujam M., Slusher, Barbara S.
Publicado 2022

Multivalent in vivo delivery of DNA-encoded bispecific T cell engagers effectively controls heterogeneous GBM tumors and mitigates immune escape

por Park, Daniel H., Liaw, Kevin, Bhojnagarwala, Pratik, Zhu, Xizhou, Choi, Jihae, Ali, Ali R., Bordoloi, Devivasha, Gary, Ebony N., O’Connell, Ryan P., Kulkarni, Abhijeet, Guimet, Diana, Smith, Trevor, Perales-Puchalt, Alfredo, Patel, Ami, Weiner, David B.
Publicado 2023

ssDNA nanotubes for selective targeting of glioblastoma and delivery of doxorubicin for enhanced survival

por Harris, Michael A., Kuang, Huihui, Schneiderman, Zachary, Shiao, Maple L., Crane, Andrew T., Chrostek, Matthew R., Tăbăran, Alexandru-Flaviu, Pengo, Thomas, Liaw, Kevin, Xu, Beibei, Lin, Lucy, Chen, Clark C., O’Sullivan, M. Gerard, Kannan, Rangaramanujam M., Low, Walter C., Kokkoli, Efrosini
Publicado 2021

Engineered antibody cytokine chimera synergizes with DNA-launched nanoparticle vaccines to potentiate melanoma suppression in vivo

por Tursi, Nicholas J., Xu, Ziyang, Helble, Michaela, Walker, Susanne, Liaw, Kevin, Chokkalingam, Neethu, Kannan, Toshitha, Wu, Yuanhan, Tello-Ruiz, Edgar, Park, Daniel H., Zhu, Xizhou, Wise, Megan C., Smith, Trevor R. F., Majumdar, Sonali, Kossenkov, Andrew, Kulp, Daniel W., Weiner, David B.
Publicado 2023

A novel mouse AAV6 hACE2 transduction model of wild-type SARS-CoV-2 infection studied using synDNA immunogens

por Gary, Ebony N., Warner, Bryce M., Parzych, Elizabeth M., Griffin, Bryan D., Zhu, Xizhou, Tailor, Nikesh, Tursi, Nicholas J., Chan, Mable, Purwar, Mansi, Vendramelli, Robert, Choi, Jihae, Frost, Kathy L., Reeder, Sophia, Liaw, Kevin, Tello, Edgar, Ali, Ali R., Yun, Kun, Pei, Yanlong, Thomas, Sylvia P., Rghei, Amira D., Guilleman, Matthew M., Muthumani, Kar, Smith, Trevor, Wootton, Sarah K., Patel, Ami, Weiner, David B., Kobasa, Darwyn
Publicado 2021

Nucleic acid delivery of immune-focused SARS-CoV-2 nanoparticles drives rapid and potent immunogenicity capable of single-dose protection

por Konrath, Kylie M., Liaw, Kevin, Wu, Yuanhan, Zhu, Xizhou, Walker, Susanne N., Xu, Ziyang, Schultheis, Katherine, Chokkalingam, Neethu, Chawla, Himanshi, Du, Jianqiu, Tursi, Nicholas J., Moore, Alan, Adolf-Bryfogle, Jared, Purwar, Mansi, Reuschel, Emma L., Frase, Drew, Sullivan, Matthew, Fry, Benjamin, Maricic, Igor, Andrade, Viviane M., Iffland, Christel, Crispin, Max, Broderick, Kate E., Humeau, Laurent M.P.F., Patel, Ami, Smith, Trevor R.F., Pallesen, Jesper, Weiner, David B., Kulp, Daniel W.
Publicado 2022

571. Safety and Immunogenicity of INO-4800, a COVID-19 DNA Vaccine as a Primary Series and Booster

por Tebas, Pablo, Agnes, Joseph, Giffear, Mary, Kraynyak, Kimberly A, Blackwood, Elliott, Amante, Dinah, Reuschel, Emma, Liu, Neiman, Purwar, Mansi, Christensen-Quick, Aaron, Andrade, Viviane M, Carter, Julie, Garufi, Gabriella, Diehl, Malissa, Sylvester, Albert, Morrow, Matthew P, Pezzoli, Patrick P, Kulkarni, Abhijeet J, Zaidi, Faraz I, Frase, Drew, Liaw, Kevin, Patel, Ami, Buttigieg, Karen R, Ervin, John E, Pawlicki, Jan, Gillespie, Elisabeth, Maricic, Igor, Schultheis, Katherine, Badie, Hedieh, Herring, Timothy A, Simon, Keiko O, Smith, Trevor R F, Ramos, Stephanie, Spitz, Robert, Lee, Jessica, Dallas, Michael, Brown, Ami Shah, Shea, Jacqueline E, Kim, J Joseph, Weiner, David, Broderick, Kate, McMullan, Trevor, Boyer, Jean, Humeau, Laurent, Mammen Jr., Mammen P
Publicado 2021