The Novel RXR Agonist MSU-42011 Differentially Regulates Gene Expression in Mammary Tumors of MMTV-Neu Mice

por Reich, Lyndsey A., Leal, Ana S., Ellsworth, Edmund, Liby, Karen T.
Publicado 2023

The Bromodomain Inhibitor, INCB057643, Targets Both Cancer Cells and the Tumor Microenvironment in Two Preclinical Models of Pancreatic Cancer

por Leal, Ana S., Liu, Phillip, Krieger-Burke, Teresa, Ruggeri, Bruce, Liby, Karen T.
Publicado 2020

CDDO-Me Redirects Activation of Breast Tumor Associated Macrophages

por Ball, Michael S., Shipman, Emilie P., Kim, Hyunjung, Liby, Karen T., Pioli, Patricia A.
Publicado 2016

A nano-liposome formulation of the PARP inhibitor Talazoparib enhances treatment efficacy and modulates immune cell populations in mammary tumors of BRCA-deficient mice

por Zhang, Di, Baldwin, Paige, Leal, Ana S., Carapellucci, Sarah, Sridhar, Srinivas, Liby, Karen T.
Publicado 2019

The Multi-Faceted Consequences of NRF2 Activation throughout Carcinogenesis

por Occhiuto, Christopher J., Moerland, Jessica A., Leal, Ana S., Gallo, Kathleen A., Liby, Karen T.
Publicado 2023

Dehydroabietic oximes halt pancreatic cancer cell growth in the G1 phase through induction of p27 and downregulation of cyclin D1

por Kolsi, Laura E., Leal, Ana S., Yli-Kauhaluoma, Jari, Liby, Karen T., Moreira, Vânia M.
Publicado 2018

The Rho/MRTF pathway inhibitor CCG-222740 reduces stellate cell activation and modulates immune cell populations in Kras(G12D); Pdx1-Cre (KC) mice

por Leal, Ana S., Misek, Sean A., Lisabeth, Erika M., Neubig, Richard R., Liby, Karen T.
Publicado 2019

Proteomic Analysis Shows Synthetic Oleanane Triterpenoid Binds to mTOR

por Yore, Mark M., Kettenbach, Arminja N., Sporn, Michael B., Gerber, Scott A., Liby, Karen T.
Publicado 2011

NRF2 as an Emerging Therapeutic Target

por Copple, Ian M., Dinkova-Kostova, Albena T., Kensler, Thomas W., Liby, Karen T., Wigley, W. Christian
Publicado 2017

Synthetic oleanane triterpenoids enhance blood brain barrier integrity and improve survival in experimental cerebral malaria

por Crowley, Valerie M., Ayi, Kodjo, Lu, Ziyue, Liby, Karen T., Sporn, Michael, Kain, Kevin C.
Publicado 2017

A Synthetic Triterpenoid CDDO-Im Inhibits Tumorsphere Formation by Regulating Stem Cell Signaling Pathways in Triple-Negative Breast Cancer

por So, Jae Young, Lin, Janice J., Wahler, Joseph, Liby, Karen T., Sporn, Michael B., Suh, Nanjoo
Publicado 2014

New Synthetic Triterpenoids: Potent Agents for Prevention and Treatment of Tissue Injury Caused by Inflammatory and Oxidative Stress

por Sporn, Michael B., Liby, Karen T., Yore, Mark M., Fu, Liangfeng, Lopchuk, Justin M., Gribble, Gordon W.
Publicado 2011

Sustained, local delivery of the PARP inhibitor talazoparib prevents the development of mammary gland hyperplasia in Brca1-deficient mice

por Zhang, Di, Singh, Bijay, Moerland, Jessica, Mitchell, Owen, Lockwood, Lizbeth, Carapellucci, Sarah, Sridhar, Srinivas, Liby, Karen T.
Publicado 2021

Identifying chemopreventive agents for obesity-associated cancers using an efficient, 3D high-throughput transformation assay

por Benham, Vanessa, Bullard, Blair, Dexheimer, Thomas S., Bernard, Matthew P., Neubig, Richard R., Liby, Karen T., Bernard, Jamie J.
Publicado 2019

The Triterpenoid CDDO-Methyl Ester Redirects Macrophage Polarization and Reduces Lung Tumor Burden in a Nrf2-Dependent Manner

por Moerland, Jessica A., Leal, Ana S., Lockwood, Beth, Demireva, Elena Y., Xie, Huirong, Krieger-Burke, Teresa, Liby, Karen T.
Publicado 2023

Retinoid X receptor agonist LG100268 modulates the immune microenvironment in preclinical breast cancer models

por Leal, Ana S., Zydeck, Kayla, Carapellucci, Sarah, Reich, Lyndsey A., Zhang, Di, Moerland, Jessica A., Sporn, Michael B., Liby, Karen T.
Publicado 2019

T Cells and CDDO-Me Attenuate Immunosuppressive Activation of Human Melanoma-Conditioned Macrophages

por Torres, Gretel M., Yang, Heetaek, Park, Chanhyuk, Spezza, Paul A., Khatwani, Nikhil, Bhandari, Rajan, Liby, Karen T., Pioli, Patricia A.
Publicado 2022

The RXR Agonist MSU42011 Is Effective for the Treatment of Preclinical HER2+ Breast Cancer and Kras-Driven Lung Cancer

por Leal, Ana S., Moerland, Jessica A., Zhang, Di, Carapellucci, Sarah, Lockwood, Beth, Krieger-Burke, Teresa, Aleiwi, Bilal, Ellsworth, Edmund, Liby, Karen T.
Publicado 2021

Adipocyte-derived kynurenine stimulates malignant transformation of mammary epithelial cells through the aryl hydrocarbon receptor

por Diedrich, Jonathan D., Gonzalez-Pons, Romina, Medeiros, Hyllana C.D., Ensink, Elliot, Liby, Karen T., Wellberg, Elizabeth A., Lunt, Sophia Y., Bernard, Jamie J.
Publicado 2023

CDDO-Me Alters the Tumor Microenvironment in Estrogen Receptor Negative Breast Cancer

por Ball, Michael S., Bhandari, Rajan, Torres, Gretel M., Martyanov, Viktor, ElTanbouly, Mohamed A., Archambault, Kim, Whitfield, Michael L., Liby, Karen T., Pioli, Patricia A.
Publicado 2020