A formal perturbation equation between genotype and phenotype determines the Evolutionary Action of protein-coding variations on fitness

por Katsonis, Panagiotis, Lichtarge, Olivier
Publicado 2014

CAGI5: Objective performance assessments of predictions based on the Evolutionary Action equation

por Katsonis, Panagiotis, Lichtarge, Olivier
Publicado 2019

Graph-based information diffusion method for prioritizing functionally related genes in protein-protein interaction networks

por Pham, Minh, Lichtarge, Olivier
Publicado 2020

Rapid detection of similarity in protein structure and function through contact metric distances

por Lisewski, Andreas Martin, Lichtarge, Olivier
Publicado 2006

Using interpretable deep learning to model cancer dependencies

por Lin, Chih-Hsu, Lichtarge, Olivier
Publicado 2021

ShinyBioHEAT: an interactive shiny app to identify phenotype driver genes in E.coli and B.subtilis

por Wang, Chen, Govindarajan, Harikumar, Katsonis, Panagiotis, Lichtarge, Olivier
Publicado 2023

An Evolutionary Trace method defines functionally important bases and sites common to RNA families

por Novikov, Ilya B., Wilkins, Angela D., Lichtarge, Olivier
Publicado 2020

Genome interpretation using in silico predictors of variant impact

por Katsonis, Panagiotis, Wilhelm, Kevin, Williams, Amanda, Lichtarge, Olivier
Publicado 2022

Function prediction from networks of local evolutionary similarity in protein structure

por Erdin, Serkan, Venner, Eric, Lisewski, Andreas Martin, Lichtarge, Olivier
Publicado 2013

Evolutionary Action–Machine Learning Model Identifies Candidate Genes Associated With Early‐Onset Coronary Artery Disease

por Shapiro, Dillon, Lee, Kwanghyuk, Asmussen, Jennifer, Bourquard, Thomas, Lichtarge, Olivier
Publicado 2023

Cooperativity of Negative Autoregulation Confers Increased Mutational Robustness

por Marciano, David C., Lua, Rhonald C., Herman, Christophe, Lichtarge, Olivier
Publicado 2016

Discovery of disease- and drug-specific pathways through community structures of a literature network

por Pham, Minh, Wilson, Stephen, Govindarajan, Harikumar, Lin, Chih-Hsu, Lichtarge, Olivier
Publicado 2020

Discovery of disease- and drug-specific pathways through community structures of a literature network

por Pham, Minh, Wilson, Stephen, Govindarajan, Harikumar, Lin, Chih-Hsu, Lichtarge, Olivier
Publicado 2020

Codon-level co-occurrences of germline variants and somatic mutations in cancer are rare but often lead to incorrect variant annotation and underestimated impact prediction

por Koire, Amanda, Kim, Young Won, Wang, Jarey, Katsonis, Panagiotis, Jin, Haijing, Lichtarge, Olivier
Publicado 2017

Predicting phenotype from genotype: Improving accuracy through more robust experimental and computational modeling

por Gallion, Jonathan, Koire, Amanda, Katsonis, Panagiotis, Schoenegge, Anne‐Marie, Bouvier, Michel, Lichtarge, Olivier
Publicado 2017

Separation of Recombination and SOS Response in Escherichia coli RecA Suggests LexA Interaction Sites

por Adikesavan, Anbu K., Katsonis, Panagiotis, Marciano, David C., Lua, Rhonald, Herman, Christophe, Lichtarge, Olivier
Publicado 2011

CovET: A covariation-evolutionary trace method that identifies protein structure–function modules

por Konecki, Daniel M., Hamrick, Spencer, Wang, Chen, Agosto, Melina A., Wensel, Theodore G., Lichtarge, Olivier
Publicado 2023

Accurate Protein Structure Annotation through Competitive Diffusion of Enzymatic Functions over a Network of Local Evolutionary Similarities

por Venner, Eric, Lisewski, Andreas Martin, Erdin, Serkan, Ward, R. Matthew, Amin, Shivas R., Lichtarge, Olivier
Publicado 2010

The Maternal-to-Zygotic Transition Targets Actin to Promote Robustness during Morphogenesis

por Zheng, Liuliu, Sepúlveda, Leonardo A., Lua, Rhonald C., Lichtarge, Olivier, Golding, Ido, Sokac, Anna Marie
Publicado 2013

Recurrent high-impact mutations at cognate structural positions in class A G protein-coupled receptors expressed in tumors

por Huh, Eunna, Gallion, Jonathan, Agosto, Melina A., Wright, Sara J., Wensel, Theodore G., Lichtarge, Olivier
Publicado 2021