A Guided Tour of the Structural Biology of Gaucher Disease: Acid-β-Glucosidase and Saposin C

por Lieberman, Raquel L.
Publicado 2011

How does a protein’s structure spell the difference between health and disease? Our journey to understand glaucoma-associated myocilin

por Lieberman, Raquel L.
Publicado 2019

Biophysical Characterization of the Olfactomedin Domain of Myocilin, an Extracellular Matrix Protein Implicated in Inherited Forms of Glaucoma

por Orwig, Susan D., Lieberman, Raquel L.
Publicado 2011

Antibodies Used to Detect Glaucoma-Associated Myocilin: More or Less Than Meets the Eye?

por Patterson-Orazem, Athéna C., Lieberman, Raquel L
Publicado 2019

Calcium-ligand variants of the myocilin olfactomedin propeller selected from invertebrate phyla reveal cross-talk with N-terminal blade and surface helices

por Hill, Shannon E., Cho, Hayeon, Raut, Priyam, Lieberman, Raquel L.
Publicado 2019

Myocilin Regulates Metalloprotease 2 Activity Through Interaction With TIMP3

por Joe, Myung Kuk, Lieberman, Raquel L., Nakaya, Naoki, Tomarev, Stanislav I.
Publicado 2017

Lipid environment modulates processivity and kinetics of a presenilin homolog acting on multiple substrates in vitro

por Wu, Yuqi, Thomas, Gwendell M., Thomsen, Max, Bahri, Sara, Lieberman, Raquel L.
Publicado 2023

Bioplastic degradation by a polyhydroxybutyrate depolymerase from a thermophilic soil bacterium

por Thomas, Gwendell M., Quirk, Stephen, Huard, Dustin J. E., Lieberman, Raquel L.
Publicado 2022

Different Grp94 components interact transiently with the myocilin olfactomedin domain in vitro to enhance or retard its amyloid aggregation

por Huard, Dustin J. E., Jonke, Alex P., Torres, Matthew P., Lieberman, Raquel L.
Publicado 2019

Molecular Details of Olfactomedin Domains Provide Pathway to Structure-Function Studies

por Hill, Shannon E., Donegan, Rebecca K., Nguyen, Elaine, Desai, Tanay M., Lieberman, Raquel L.
Publicado 2015

Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability

por Scelsi, Hailee F., Hill, Kamisha R., Barlow, Brett M., Martin, Mackenzie D., Lieberman, Raquel L.
Publicado 2023

Metal ion coordination in the E. coli Nudix hydrolase dihydroneopterin triphosphate pyrophosphatase: New clues into catalytic mechanism

por Hill, Shannon E., Nguyen, Elaine, Ukachukwu, Chiamaka U., Freeman, Dana M., Quirk, Stephen, Lieberman, Raquel L.
Publicado 2017

Substrate–Enzyme Interactions in Intramembrane Proteolysis: γ-Secretase as the Prototype

por Liu, Xinyue, Zhao, Jing, Zhang, Yingkai, Ubarretxena-Belandia, Iban, Forth, Scott, Lieberman, Raquel L., Wang, Chunyu
Publicado 2020

Progranulin deficiency leads to reduced glucocerebrosidase activity

por Zhou, Xiaolai, Paushter, Daniel H., Pagan, Mitchell D., Kim, Dongsung, Nunez Santos, Mariela, Lieberman, Raquel L., Overkleeft, Herman S., Sun, Ying, Smolka, Marcus B., Hu, Fenghua
Publicado 2019

Molecular basis for inhibition of methane clathrate growth by a deep subsurface bacterial protein

por Huard, Dustin J E, Johnson, Abigail M, Fan, Zixing, Kenney, Lydia G, Xu, Manlin, Drori, Ran, Gumbart, James C, Dai, Sheng, Lieberman, Raquel L, Glass, Jennifer B
Publicado 2023

Recombinant antibodies recognize conformation-dependent epitopes of the leucine zipper of misfolding-prone myocilin

por Patterson-Orazem, Athéna C., Qerqez, Ahlam N., Azouz, Laura R., Ma, Minh Thu, Hill, Shannon E., Ku, Yemo, Schildmeyer, Lisa A., Maynard, Jennifer A., Lieberman, Raquel L.
Publicado 2021

De novo design of antibody complementarity determining regions binding a FLAG tetra-peptide

por Entzminger, Kevin C., Hyun, Jeong-min, Pantazes, Robert J., Patterson-Orazem, Athena C., Qerqez, Ahlam N., Frye, Zach P., Hughes, Randall A., Ellington, Andrew D., Lieberman, Raquel L., Maranas, Costas D., Maynard, Jennifer A.
Publicado 2017

Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability

por Goldenzweig, Adi, Goldsmith, Moshe, Hill, Shannon E., Gertman, Or, Laurino, Paola, Ashani, Yacov, Dym, Orly, Unger, Tamar, Albeck, Shira, Prilusky, Jaime, Lieberman, Raquel L., Aharoni, Amir, Silman, Israel, Sussman, Joel L., Tawfik, Dan S., Fleishman, Sarel J.
Publicado 2016

Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability

por Goldenzweig, Adi, Goldsmith, Moshe, Hill, Shannon E., Gertman, Or, Laurino, Paola, Ashani, Yacov, Dym, Orly, Unger, Tamar, Albeck, Shira, Prilusky, Jaime, Lieberman, Raquel L., Aharoni, Amir, Silman, Israel, Sussman, Joel L., Tawfik, Dan S., Fleishman, Sarel J.
Publicado 2018

Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma

por Stothert, Andrew R., Suntharalingam, Amirthaa, Tang, Xiaolan, Crowley, Vincent M., Mishra, Sanket J., Webster, Jack M., Nordhues, Bryce A., Huard, Dustin J. E., Passaglia, Christopher L., Lieberman, Raquel L., Blagg, Brian S. J., Blair, Laura J., Koren, John, Dickey, Chad A.
Publicado 2017