Kinome profiling of cholangiocarcinoma organoids reveals potential druggable targets that hold promise for treatment stratification

por Lieshout, Ruby, Faria, Alessandra V. S., Peppelenbosch, Maikel P., van der Laan, Luc J. W., Verstegen, Monique M. A., Fuhler, Gwenny M.
Publicado 2022

Label-Free Imaging Analysis of Patient-Derived Cholangiocarcinoma Organoids after Sorafenib Treatment

por Koch, Michael, Nickel, Sandra, Lieshout, Ruby, Lissek, Susanna M., Leskova, Martina, van der Laan, Luc J. W., Verstegen, Monique M. A., Christ, Bruno, Pampaloni, Francesco
Publicado 2022

Mitochondrial Fusion Via OPA1 and MFN1 Supports Liver Tumor Cell Metabolism and Growth

por Li, Meng, Wang, Ling, Wang, Yijin, Zhang, Shaoshi, Zhou, Guoying, Lieshout, Ruby, Ma, Buyun, Liu, Jiaye, Qu, Changbo, Verstegen, Monique M. A., Sprengers, Dave, Kwekkeboom, Jaap, van der Laan, Luc J. W., Cao, Wanlu, Peppelenbosch, Maikel P., Pan, Qiuwei
Publicado 2020

Cholangiocyte organoids from human bile retain a local phenotype and can repopulate bile ducts in vitro

por Roos, Floris J. M., Wu, Haoyu, Willemse, Jorke, Lieshout, Ruby, Albarinos, Laura A. Muñoz, Kan, Yik‐Yang, Poley, Jan‐Werner, Bruno, Marco J., de Jonge, Jeroen, Bártfai, Richard, Marks, Hendrik, IJzermans, Jan N. M., Verstegen, Monique M. A., van der Laan, Luc J. W.
Publicado 2021

Precancerous liver diseases do not cause increased mutagenesis in liver stem cells

por Nguyen, Luan, Jager, Myrthe, Lieshout, Ruby, de Ruiter, Petra E., Locati, Mauro D., Besselink, Nicolle, van der Roest, Bastiaan, Janssen, Roel, Boymans, Sander, de Jonge, Jeroen, IJzermans, Jan N. M., Doukas, Michail, Verstegen, Monique M. A., van Boxtel, Ruben, van der Laan, Luc J. W., Cuppen, Edwin, Kuijk, Ewart
Publicado 2021

Modelling immune cytotoxicity for cholangiocarcinoma with tumour-derived organoids and effector T cells

por Zhou, Guoying, Lieshout, Ruby, van Tienderen, Gilles S., de Ruiter, Valeska, van Royen, Martin E., Boor, Patrick P. C., Magré, Luc, Desai, Jyaysi, Köten, Kübra, Kan, Yik Yang, Ge, Zhouhong, Campos Carrascosa, Lucia, Geuijen, Cecile, Sprengers, Dave, van der Laan, Luc J. W., Verstegen, Monique M. A., Kwekkeboom, Jaap
Publicado 2022

Cancer-Associated Fibroblasts Provide a Stromal Niche for Liver Cancer Organoids That Confers Trophic Effects and Therapy Resistance

por Liu, Jiaye, Li, Pengfei, Wang, Ling, Li, Meng, Ge, Zhouhong, Noordam, Lisanne, Lieshout, Ruby, Verstegen, Monique M.A., Ma, Buyun, Su, Junhong, Yang, Qin, Zhang, Ruyi, Zhou, Guoying, Carrascosa, Lucia Campos, Sprengers, Dave, IJzermans, Jan N.M., Smits, Ron, Kwekkeboom, Jaap, van der Laan, Luc J.W., Peppelenbosch, Maikel P., Pan, Qiuwei, Cao, Wanlu
Publicado 2020

Large‐Scale Production of LGR5‐Positive Bipotential Human Liver Stem Cells

por Schneeberger, Kerstin, Sánchez‐Romero, Natalia, Ye, Shicheng, van Steenbeek, Frank G., Oosterhoff, Loes A., Pla Palacin, Iris, Chen, Chen, van Wolferen, Monique E., van Tienderen, Gilles, Lieshout, Ruby, Colemonts‐Vroninks, Haaike, Schene, Imre, Hoekstra, Ruurdtje, Verstegen, Monique M.A., van der Laan, Luc J.W., Penning, Louis C., Fuchs, Sabine A., Clevers, Hans, De Kock, Joery, Baptista, Pedro M., Spee, Bart
Publicado 2020

Human Primary Liver Cancer -derived Organoid Cultures for disease modelling and drug screening

por Broutier, Laura, Mastrogiovanni, Gianmarco, Verstegen, Monique M.A., Francies, Hayley E., Gavarró, Lena Morrill, Bradshaw, Charles R, Allen, George E, Arnes-Benito, Robert, Sidorova, Olga, Gaspersz, Marcia P., Georgakopoulos, Nikitas, Koo, Bon-Kyoung, Dietmann, Sabine, Davies, Susan E., Praseedom, Raaj K., Lieshout, Ruby, IJzermans, Jan N. M., Wigmore, Stephen J, Saeb-Parsy, Kourosh, Garnett, Mathew J., van der Laan, Luc J.W., Huch, Meritxell
Publicado 2017