High-throughput RNAi screen for essential genes and drug synergistic combinations in colorectal cancer

por Williams, Steven P., Barthorpe, Andrew S., Lightfoot, Howard, Garnett, Mathew J., McDermott, Ultan
Publicado 2017

Corrigendum: High-throughput RNAi screen for essential genes and drug synergistic combinations in colorectal cancer

por Williams, Steven P., Barthorpe, Andrew S., Lightfoot, Howard, Garnett, Mathew J., McDermott, Ultan
Publicado 2018

GDSCTools for mining pharmacogenomic interactions in cancer

por Cokelaer, Thomas, Chen, Elisabeth, Iorio, Francesco, Menden, Michael P, Lightfoot, Howard, Saez-Rodriguez, Julio, Garnett, Mathew J
Publicado 2018

Cell Model Passports—a hub for clinical, genetic and functional datasets of preclinical cancer models

por van der Meer, Dieudonne, Barthorpe, Syd, Yang, Wanjuan, Lightfoot, Howard, Hall, Caitlin, Gilbert, James, Francies, Hayley E, Garnett, Mathew J
Publicado 2019

Project Score database: a resource for investigating cancer cell dependencies and prioritizing therapeutic targets

por Dwane, Lisa, Behan, Fiona M, Gonçalves, Emanuel, Lightfoot, Howard, Yang, Wanjuan, van der Meer, Dieudonne, Shepherd, Rebecca, Pignatelli, Miguel, Iorio, Francesco, Garnett, Mathew J
Publicado 2020

Integrated cross-study datasets of genetic dependencies in cancer

por Pacini, Clare, Dempster, Joshua M., Boyle, Isabella, Gonçalves, Emanuel, Najgebauer, Hanna, Karakoc, Emre, van der Meer, Dieudonne, Barthorpe, Andrew, Lightfoot, Howard, Jaaks, Patricia, McFarland, James M., Garnett, Mathew J., Tsherniak, Aviad, Iorio, Francesco
Publicado 2021

A suspension technique for efficient large-scale cancer organoid culturing and perturbation screens

por Price, Stacey, Bhosle, Shriram, Gonçalves, Emanuel, Li, Xiaodun, McClurg, Dylan P., Barthorpe, Syd, Beck, Alex, Hall, Caitlin, Lightfoot, Howard, Farrow, Luke, Ansari, Rizwan, Jackson, David A., Allen, Laura, Roberts, Kirsty, Beaver, Charlotte, Francies, Hayley E., Garnett, Mathew J.
Publicado 2022

Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells

por Yang, Wanjuan, Soares, Jorge, Greninger, Patricia, Edelman, Elena J., Lightfoot, Howard, Forbes, Simon, Bindal, Nidhi, Beare, Dave, Smith, James A., Thompson, I. Richard, Ramaswamy, Sridhar, Futreal, P. Andrew, Haber, Daniel A., Stratton, Michael R., Benes, Cyril, McDermott, Ultan, Garnett, Mathew J.
Publicado 2013

Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics

por Li, Xiaodun, Francies, Hayley E., Secrier, Maria, Perner, Juliane, Miremadi, Ahmad, Galeano-Dalmau, Núria, Barendt, William J., Letchford, Laura, Leyden, Genevieve M., Goffin, Emma K., Barthorpe, Andrew, Lightfoot, Howard, Chen, Elisabeth, Gilbert, James, Noorani, Ayesha, Devonshire, Ginny, Bower, Lawrence, Grantham, Amber, MacRae, Shona, Grehan, Nicola, Wedge, David C., Fitzgerald, Rebecca C., Garnett, Mathew J.
Publicado 2018

Drug mechanism‐of‐action discovery through the integration of pharmacological and CRISPR screens

por Gonçalves, Emanuel, Segura‐Cabrera, Aldo, Pacini, Clare, Picco, Gabriele, Behan, Fiona M, Jaaks, Patricia, Coker, Elizabeth A, van der Meer, Donny, Barthorpe, Andrew, Lightfoot, Howard, Mironenko, Tatiana, Beck, Alexandra, Richardson, Laura, Yang, Wanjuan, Lleshi, Ermira, Hall, James, Tolley, Charlotte, Hall, Caitlin, Mali, Iman, Thomas, Frances, Morris, James, Leach, Andrew R, Lynch, James T, Sidders, Ben, Crafter, Claire, Iorio, Francesco, Fawell, Stephen, Garnett, Mathew J
Publicado 2020

Effective drug combinations in breast, colon and pancreatic cancer cells

por Jaaks, Patricia, Coker, Elizabeth A., Vis, Daniel J., Edwards, Olivia, Carpenter, Emma F., Leto, Simonetta M., Dwane, Lisa, Sassi, Francesco, Lightfoot, Howard, Barthorpe, Syd, van der Meer, Dieudonne, Yang, Wanjuan, Beck, Alexandra, Mironenko, Tatiana, Hall, Caitlin, Hall, James, Mali, Iman, Richardson, Laura, Tolley, Charlotte, Morris, James, Thomas, Frances, Lleshi, Ermira, Aben, Nanne, Benes, Cyril H., Bertotti, Andrea, Trusolino, Livio, Wessels, Lodewyk, Garnett, Mathew J.
Publicado 2022

Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells

por Kolluri, Krishna Kalyan, Alifrangis, Constantine, Kumar, Neelam, Ishii, Yuki, Price, Stacey, Michaut, Magali, Williams, Steven, Barthorpe, Syd, Lightfoot, Howard, Busacca, Sara, Sharkey, Annabel, Yuan, Zhenqiang, Sage, Elizabeth K, Vallath, Sabarinath, Le Quesne, John, Tice, David A, Alrifai, Doraid, von Karstedt, Sylvia, Montinaro, Antonella, Guppy, Naomi, Waller, David A, Nakas, Apostolos, Good, Robert, Holmes, Alan, Walczak, Henning, Fennell, Dean A, Garnett, Mathew, Iorio, Francesco, Wessels, Lodewyk, McDermott, Ultan, Janes, Samuel M
Publicado 2018

A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds

por Bruna, Alejandra, Rueda, Oscar M., Greenwood, Wendy, Batra, Ankita Sati, Callari, Maurizio, Batra, Rajbir Nath, Pogrebniak, Katherine, Sandoval, Jose, Cassidy, John W., Tufegdzic-Vidakovic, Ana, Sammut, Stephen-John, Jones, Linda, Provenzano, Elena, Baird, Richard, Eirew, Peter, Hadfield, James, Eldridge, Matthew, McLaren-Douglas, Anne, Barthorpe, Andrew, Lightfoot, Howard, O’Connor, Mark J., Gray, Joe, Cortes, Javier, Baselga, Jose, Marangoni, Elisabetta, Welm, Alana L., Aparicio, Samuel, Serra, Violeta, Garnett, Mathew J., Caldas, Carlos
Publicado 2016

Pan-cancer proteomic map of 949 human cell lines

por Gonçalves, Emanuel, Poulos, Rebecca C., Cai, Zhaoxiang, Barthorpe, Syd, Manda, Srikanth S., Lucas, Natasha, Beck, Alexandra, Bucio-Noble, Daniel, Dausmann, Michael, Hall, Caitlin, Hecker, Michael, Koh, Jennifer, Lightfoot, Howard, Mahboob, Sadia, Mali, Iman, Morris, James, Richardson, Laura, Seneviratne, Akila J., Shepherd, Rebecca, Sykes, Erin, Thomas, Frances, Valentini, Sara, Williams, Steven G., Wu, Yangxiu, Xavier, Dylan, MacKenzie, Karen L., Hains, Peter G., Tully, Brett, Robinson, Phillip J., Zhong, Qing, Garnett, Mathew J., Reddel, Roger R.
Publicado 2022

A Landscape of Pharmacogenomic Interactions in Cancer

por Iorio, Francesco, Knijnenburg, Theo A., Vis, Daniel J., Bignell, Graham R., Menden, Michael P., Schubert, Michael, Aben, Nanne, Gonçalves, Emanuel, Barthorpe, Syd, Lightfoot, Howard, Cokelaer, Thomas, Greninger, Patricia, van Dyk, Ewald, Chang, Han, de Silva, Heshani, Heyn, Holger, Deng, Xianming, Egan, Regina K., Liu, Qingsong, Mironenko, Tatiana, Mitropoulos, Xeni, Richardson, Laura, Wang, Jinhua, Zhang, Tinghu, Moran, Sebastian, Sayols, Sergi, Soleimani, Maryam, Tamborero, David, Lopez-Bigas, Nuria, Ross-Macdonald, Petra, Esteller, Manel, Gray, Nathanael S., Haber, Daniel A., Stratton, Michael R., Benes, Cyril H., Wessels, Lodewyk F.A., Saez-Rodriguez, Julio, McDermott, Ultan, Garnett, Mathew J.
Publicado 2016