IKKβ slows Huntington’s disease progression in R6/1 mice

por Ochaba, Joseph, Fote, Gianna, Kachemov, Marketta, Thein, Soe, Yeung, Sylvia Y., Lau, Alice L., Hernandez, Sarah, Lim, Ryan G., Casale, Malcolm, Neel, Michael J., Monuki, Edwin S., Reidling, Jack, Housman, David E., Thompson, Leslie M., Steffan, Joan S.
Publicado 2019

Huntington’s Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits

por Lim, Ryan G., Quan, Chris, Reyes-Ortiz, Andrea M., Lutz, Sarah E., Kedaigle, Amanda J., Gipson, Theresa A., Wu, Jie, Vatine, Gad D., Stocksdale, Jennifer, Casale, Malcolm S., Svendsen, Clive N., Fraenkel, Ernest, Housman, David E., Agalliu, Dritan, Thompson, Leslie M.
Publicado 2017

Aberrant Development Corrected in Adult-Onset Huntington's Disease iPSC-Derived Neuronal Cultures via WNT Signaling Modulation

por Smith-Geater, Charlene, Hernandez, Sarah J., Lim, Ryan G., Adam, Miriam, Wu, Jie, Stocksdale, Jennifer T., Wassie, Brook T., Gold, Maxwell Philip, Wang, Keona Q., Miramontes, Ricardo, Kopan, Lexi, Orellana, Iliana, Joy, Shona, Kemp, Paul J., Allen, Nicholas D., Fraenkel, Ernest, Thompson, Leslie M.
Publicado 2020

An altered extracellular matrix–integrin interface contributes to Huntington’s disease-associated CNS dysfunction in glial and vascular cells

por Hernandez, Sarah J, Lim, Ryan G, Onur, Tarik, Dane, Mark A, Smith, Rebecca, Wang, Keona, Jean, Grace En-Hway, Reyes-Ortiz, Andrea, Devlin, Kaylyn, Miramontes, Ricardo, Wu, Jie, Casale, Malcolm, Kilburn, David, Heiser, Laura M, Korkola, James E, Van Vactor, David, Botas, Juan, Thompson-Peer, Katherine L, Thompson, Leslie M
Publicado 2022

Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits

por Reyes-Ortiz, Andrea M., Abud, Edsel M., Burns, Mara S., Wu, Jie, Hernandez, Sarah J., McClure, Nicolette, Wang, Keona Q., Schulz, Corey J., Miramontes, Ricardo, Lau, Alice, Michael, Neethu, Miyoshi, Emily, Van Vactor, David, Reidling, John C., Blurton-Jones, Mathew, Swarup, Vivek, Poon, Wayne W., Lim, Ryan G., Thompson, Leslie M.
Publicado 2022

Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects

por Workman, Michael J., Lim, Ryan G., Wu, Jie, Frank, Aaron, Ornelas, Loren, Panther, Lindsay, Galvez, Erick, Perez, Daniel, Meepe, Imara, Lei, Susan, Valencia, Viviana, Gomez, Emilda, Liu, Chunyan, Moran, Ruby, Pinedo, Louis, Tsitkov, Stanislav, Ho, Ritchie, Kaye, Julia A., Thompson, Terri, Rothstein, Jeffrey D., Finkbeiner, Steven, Fraenkel, Ernest, Sareen, Dhruv, Thompson, Leslie M., Svendsen, Clive N.
Publicado 2023

PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington’s disease

por Morozko, Eva L., Smith-Geater, Charlene, Monteys, Alejandro Mas, Pradhan, Subrata, Lim, Ryan G., Langfelder, Peter, Kachemov, Marketta, Hill, Austin, Stocksdale, Jennifer T., Cullis, Pieter R., Wu, Jie, Ochaba, Joseph, Miramontes, Ricardo, Chakraborty, Anirban, Hazra, Tapas K., Lau, Alice, St-cyr, Sophie, Orellana, Iliana, Kopan, Lexi, Wang, Keona Q., Yeung, Sylvia, Leavitt, Blair R., Reidling, Jack C., Yang, X. William, Steffan, Joan S., Davidson, Beverly L., Sarkar, Partha S., Thompson, Leslie M.
Publicado 2021

Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation

por Lim, Ryan G., Al-Dalahmah, Osama, Wu, Jie, Gold, Maxwell P., Reidling, Jack C., Tang, Guomei, Adam, Miriam, Dansu, David K., Park, Hye-Jin, Casaccia, Patrizia, Miramontes, Ricardo, Reyes-Ortiz, Andrea M., Lau, Alice, Hickman, Richard A., Khan, Fatima, Paryani, Fahad, Tang, Alice, Ofori, Kenneth, Miyoshi, Emily, Michael, Neethu, McClure, Nicolette, Flowers, Xena E., Vonsattel, Jean Paul, Davidson, Shawn, Menon, Vilas, Swarup, Vivek, Fraenkel, Ernest, Goldman, James E., Thompson, Leslie M.
Publicado 2022

An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients

por Li, Jonathan, Lim, Ryan G., Kaye, Julia A., Dardov, Victoria, Coyne, Alyssa N., Wu, Jie, Milani, Pamela, Cheng, Andrew, Thompson, Terri G., Ornelas, Loren, Frank, Aaron, Adam, Miriam, Banuelos, Maria G., Casale, Malcolm, Cox, Veerle, Escalante-Chong, Renan, Daigle, J. Gavin, Gomez, Emilda, Hayes, Lindsey, Holewenski, Ronald, Lei, Susan, Lenail, Alex, Lima, Leandro, Mandefro, Berhan, Matlock, Andrea, Panther, Lindsay, Patel-Murray, Natasha Leanna, Pham, Jacqueline, Ramamoorthy, Divya, Sachs, Karen, Shelley, Brandon, Stocksdale, Jennifer, Trost, Hannah, Wilhelm, Mark, Venkatraman, Vidya, Wassie, Brook T., Wyman, Stacia, Yang, Stephanie, Van Eyk, Jennifer E., Lloyd, Thomas E., Finkbeiner, Steven, Fraenkel, Ernest, Rothstein, Jeffrey D., Sareen, Dhruv, Svendsen, Clive N., Thompson, Leslie M.
Publicado 2021

Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines

por Baxi, Emily G., Thompson, Terri, Li, Jonathan, Kaye, Julia A., Lim, Ryan G., Wu, Jie, Ramamoorthy, Divya, Lima, Leandro, Vaibhav, Vineet, Matlock, Andrea, Frank, Aaron, Coyne, Alyssa N., Landin, Barry, Ornelas, Loren, Mosmiller, Elizabeth, Thrower, Sara, Farr, S. Michelle, Panther, Lindsey, Gomez, Emilda, Galvez, Erick, Perez, Daniel, Meepe, Imara, Lei, Susan, Mandefro, Berhan, Trost, Hannah, Pinedo, Louis, Banuelos, Maria G., Liu, Chunyan, Moran, Ruby, Garcia, Veronica, Workman, Michael, Ho, Richie, Wyman, Stacia, Roggenbuck, Jennifer, Harms, Matthew B., Stocksdale, Jennifer, Miramontes, Ricardo, Wang, Keona, Venkatraman, Vidya, Holewenski, Ronald, Sundararaman, Niveda, Pandey, Rakhi, Manalo, Danica-Mae, Donde, Aneesh, Huynh, Nhan, Adam, Miriam, Wassie, Brook T., Vertudes, Edward, Amirani, Naufa, Raja, Krishna, Thomas, Reuben, Hayes, Lindsey, Lenail, Alex, Cerezo, Aianna, Luppino, Sarah, Farrar, Alanna, Pothier, Lindsay, Prina, Carolyn, Morgan, Todd, Jamil, Arish, Heintzman, Sarah, Jockel-Balsarotti, Jennifer, Karanja, Elizabeth, Markway, Jesse, McCallum, Molly, Joslin, Ben, Alibazoglu, Deniz, Kolb, Stephen, Ajroud-Driss, Senda, Baloh, Robert, Heitzman, Daragh, Miller, Tim, Glass, Jonathan D., Patel-Murray, Natasha Leanna, Yu, Hong, Sinani, Ervin, Vigneswaran, Prasha, Sherman, Alexander V., Ahmad, Omar, Roy, Promit, Beavers, Jay C., Zeiler, Steven, Krakauer, John W., Agurto, Carla, Cecchi, Guillermo, Bellard, Mary, Raghav, Yogindra, Sachs, Karen, Ehrenberger, Tobias, Bruce, Elizabeth, Cudkowicz, Merit E., Maragakis, Nicholas, Norel, Raquel, Van Eyk, Jennifer E., Finkbeiner, Steven, Berry, James, Sareen, Dhruv, Thompson, Leslie M., Fraenkel, Ernest, Svendsen, Clive N., Rothstein, Jeffrey D.
Publicado 2022