Development of a nano-luciferase based assay to measure the binding of SARS-CoV-2 spike receptor binding domain to ACE-2

por Lima, Marcelo A., Skidmore, Mark, Khanim, Farhat, Richardson, Alan
Publicado 2021

SULF2 overexpression positively regulates tumorigenicity of human prostate cancer cells

por Vicente, Carolina M, Lima, Marcelo A, Nader, Helena B, Toma, Leny
Publicado 2015

Insights into the N-Sulfation Mechanism: Molecular Dynamics Simulations of the N-Sulfotransferase Domain of Ndst1 and Mutants

por Gesteira, Tarsis F., Pol-Fachin, Laércio, Coulson-Thomas, Vivien Jane, Lima, Marcelo A., Verli, Hugo, Nader, Helena B.
Publicado 2013

Crude Heparin Preparations Unveil the Presence of Structurally Diverse Oversulfated Contaminants

por Mendes, Aline, Meneghetti, Maria C. Z., Palladino, Marcelly Valle, Justo, Giselle Zenker, Sassaki, Guilherme L., Fareed, Jawed, Lima, Marcelo A., Nader, Helena B.
Publicado 2019

A Glycosaminoglycan Extract from Portunus pelagicus Inhibits BACE1, the β Secretase Implicated in Alzheimer’s Disease

por Mycroft-West, Courtney J., Cooper, Lynsay C., Devlin, Anthony J., Procter, Patricia, Guimond, Scott E., Guerrini, Marco, Fernig, David G., Lima, Marcelo A., Yates, Edwin A., Skidmore, Mark A.
Publicado 2019

THE M-RNA, EXPRESSION OF SERCA2 AND NCX1 IN THE PROCESS OF PHARMACOLOGICAL CELL PROTECTION IN EXPERIMENTAL ACUTE PANCREATITIS INDUCED BY TAUROCHOLATE

por VASQUES, Enio Rodrigues, CUNHA, José Eduardo Monteiro, KUBRUSLY, Marcia Saldanha, COELHO, Ana Maria, SANPIETRI, Sandra N., NADER, Helena B., TERSARIOL, Ivarne L.S., LIMA, Marcelo A., CHAIB, Eleazar, D’ALBUQUERQUE, Luiz Augusto Carneiro
Publicado 2018

Inhibition of BACE1, the β-secretase implicated in Alzheimer’s disease, by a chondroitin sulfate extract from Sardina pilchardus

por Mycroft-West, Courtney J., Devlin, Anthony J., Cooper, Lynsay C., Procter, Patricia, Miller, Gavin J., Fernig, David G., Guerrini, Marco, Guimond, Scott E., Lima, Marcelo A., Yates, Edwin A., Skidmore, Mark Andrew
Publicado 2020

Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells

por Ghezzi, Silvia, Cooper, Lynsay, Rubio, Alicia, Pagani, Isabel, Capobianchi, Maria Rosaria, Ippolito, Giuseppe, Pelletier, Julien, Meneghetti, Maria Cecilia Z., Lima, Marcelo A., Skidmore, Mark A., Broccoli, Vania, Yates, Edwin A., Vicenzi, Elisa
Publicado 2017

Glycosaminoglycans from Litopenaeus vannamei Inhibit the Alzheimer’s Disease β Secretase, BACE1

por Mycroft-West, Courtney J., Devlin, Anthony J., Cooper, Lynsay C., Guimond, Scott E., Procter, Patricia, Guerrini, Marco, Miller, Gavin J., Fernig, David G., Yates, Edwin A., Lima, Marcelo A., Skidmore, Mark A.
Publicado 2021

Using NMR to Dissect the Chemical Space and O-Sulfation Effects within the O- and S-Glycoside Analogues of Heparan Sulfate

por Meneghetti, Maria C.Z., Naughton, Lucy, O’Shea, Conor, Koffi Teki, Dindet S.-E., Chagnault, Vincent, Nader, Helena B., Rudd, Timothy R., Yates, Edwin A., Kovensky, José, Miller, Gavin J., Lima, Marcelo A.
Publicado 2022

Virtual screening, identification and in vitro validation of small molecule GDP-mannose dehydrogenase inhibitors

por Dolan, Jonathan P., Ahmadipour, Sanaz, Wahart, Alice J. C., Cheallaigh, Aisling Ní, Sari, Suat, Eurtivong, Chatchakorn, Lima, Marcelo A., Skidmore, Mark A., Volcho, Konstantin P., Reynisson, Jóhannes, Field, Robert A., Miller, Gavin J.
Publicado 2023

Heparin Oligosaccharides Have Antiarrhythmic Effect by Accelerating the Sodium-Calcium Exchanger

por de Godoy, Carlos M. G., Vasques, Ênio R., Caricati-Neto, Afonso, Tavares, José G. P., Alves, Beatriz J., Duarte, Juliana, Miranda-Ferreira, Regiane, Lima, Marcelo A., Nader, Helena B., Tersariol, Ivarne L. dos Santos
Publicado 2018

Evidence of a putative glycosaminoglycan binding site on the glycosylated SARS-CoV-2 spike protein N-terminal domain

por Schuurs, Zachariah P., Hammond, Edward, Elli, Stefano, Rudd, Timothy R., Mycroft-West, Courtney J., Lima, Marcelo A., Skidmore, Mark A., Karlsson, Richard, Chen, Yen-Hsi, Bagdonaite, Ieva, Yang, Zhang, Ahmed, Yassir A., Richard, Derek J., Turnbull, Jeremy, Ferro, Vito, Coombe, Deirdre R., Gandhi, Neha S.
Publicado 2021

A New Approach for Heparin Standardization: Combination of Scanning UV Spectroscopy, Nuclear Magnetic Resonance and Principal Component Analysis

por Lima, Marcelo A., Rudd, Timothy R., de Farias, Eduardo H. C., Ebner, Lyvia F., Gesteira, Tarsis F., de Souza, Lauro M., Mendes, Aline, Córdula, Carolina R., Martins, João R. M., Hoppensteadt, Debra, Fareed, Jawed, Sassaki, Guilherme L., Yates, Edwin A., Tersariol, Ivarne L. S., Nader, Helena B.
Publicado 2011

Unfractionated heparin inhibits live wild type SARS‐CoV‐2 cell infectivity at therapeutically relevant concentrations

por Tree, Julia A., Turnbull, Jeremy E., Buttigieg, Karen R., Elmore, Michael J., Coombes, Naomi, Hogwood, John, Mycroft‐West, Courtney J., Lima, Marcelo A., Skidmore, Mark A., Karlsson, Richard, Chen, Yen‐Hsi, Yang, Zhang, Spalluto, Cosma Mirella, Staples, Karl J., Yates, Edwin A., Gray, Elaine, Singh, Dave, Wilkinson, Tom, Page, Clive P., Carroll, Miles W.
Publicado 2020

Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike–ACE2 Interaction

por Guimond, Scott E., Mycroft-West, Courtney J., Gandhi, Neha S., Tree, Julia A., Le, Thuy T., Spalluto, C. Mirella, Humbert, Maria V., Buttigieg, Karen R., Coombes, Naomi, Elmore, Michael J., Wand, Matthew, Nyström, Kristina, Said, Joanna, Setoh, Yin Xiang, Amarilla, Alberto A., Modhiran, Naphak, Sng, Julian D. J., Chhabra, Mohit, Young, Paul R., Rawle, Daniel J., Lima, Marcelo A., Yates, Edwin A., Karlsson, Richard, Miller, Rebecca L., Chen, Yen-Hsi, Bagdonaite, Ieva, Yang, Zhang, Stewart, James, Nguyen, Dung, Laidlaw, Stephen, Hammond, Edward, Dredge, Keith, Wilkinson, Tom M. A., Watterson, Daniel, Khromykh, Alexander A., Suhrbier, Andreas, Carroll, Miles W., Trybala, Edward, Bergström, Tomas, Ferro, Vito, Skidmore, Mark A., Turnbull, Jeremy E.
Publicado 2022