Reduced levels of Ago2 expression result in increased siRNA competition in mammalian cells

por Vickers, Timothy A., Lima, Walt F., Nichols, Josh G., Crooke, Stanley T.
Publicado 2007

Human RNase H1 Is Associated with Protein P32 and Is Involved in Mitochondrial Pre-rRNA Processing

por Wu, Hongjiang, Sun, Hong, Liang, Xuehai, Lima, Walt F., Crooke, Stanley T.
Publicado 2013

Defining the Factors That Contribute to On-Target Specificity of Antisense Oligonucleotides

por Lima, Walt F., Vickers, Timothy A., Nichols, Josh, Li, Cheryl, Crooke, Stanley T.
Publicado 2014

RNA cleavage products generated by antisense oligonucleotides and siRNAs are processed by the RNA surveillance machinery

por Lima, Walt F., De Hoyos, Cheryl L., Liang, Xue-hai, Crooke, Stanley T.
Publicado 2016

Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 ‘Slicer’ independent and can be mediated by Ago1

por Vickers, Timothy A., Lima, Walt F., Wu, Hongjiang, Nichols, Josh G., Linsley, Peter S., Crooke, Stanley T.
Publicado 2009

Fluorinated Nucleotide Modifications Modulate Allele Selectivity of SNP-Targeting Antisense Oligonucleotides

por Østergaard, Michael E., Nichols, Josh, Dwight, Timothy A., Lima, Walt, Jung, Michael E., Swayze, Eric E., Seth, Punit P.
Publicado 2017

ss-siRNAs allele selectively inhibit ataxin-3 expression: multiple mechanisms for an alternative gene silencing strategy

por Liu, Jing, Yu, Dongbo, Aiba, Yuichiro, Pendergraff, Hannah, Swayze, Eric E., Lima, Walt F., Hu, Jiaxin, Prakash, Thazha P., Corey, David R.
Publicado 2013

Viable RNaseH1 knockout mice show RNaseH1 is essential for R loop processing, mitochondrial and liver function

por Lima, Walt F., Murray, Heather M., Damle, Sagar S., Hart, Christopher E., Hung, Gene, De Hoyos, Cheryl Li, Liang, Xue-Hai, Crooke, Stanley T.
Publicado 2016

Identification of metabolically stable 5′-phosphate analogs that support single-stranded siRNA activity

por Prakash, Thazha P., Lima, Walt F., Murray, Heather M., Li, Wenyu, Kinberger, Garth A., Chappell, Alfred E., Gaus, Hans, Seth, Punit P., Bhat, Balkrishen, Crooke, Stanley T., Swayze, Eric E.
Publicado 2015

Identification of metabolically stable 5΄-phosphate analogs that support single-stranded siRNA activity

por Prakash, Thazha P., Lima, Walt F., Murray, Heather M., Li, Wenyu, Kinberger, Garth A., Chappell, Alfred E., Gaus, Hans, Seth, Punit P., Bhat, Balkrishen, Crooke, Stanley T., Swayze, Eric E.
Publicado 2017

Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages

por Wan, W. Brad, Migawa, Michael T., Vasquez, Guillermo, Murray, Heather M., Nichols, Josh G., Gaus, Hans, Berdeja, Andres, Lee, Sam, Hart, Christopher E., Lima, Walt F., Swayze, Eric E., Seth, Punit P.
Publicado 2014

Allele-Selective Inhibition of Mutant Atrophin-1 Expression by Duplex and Single-Stranded RNAs

por Hu, Jiaxin, Liu, Jing, Narayanannair, K. Jayaprakash, Lackey, Jeremy G., Kuchimanchi, Satya, Rajeev, Kallanthottathil G., Manoharan, Muthiah, Swayze, Eric E., Lima, Walt F., Prakash, Thazha P., Xiang, Qin, Martinez, Carlos, Corey, David R.
Publicado 2014

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice

por Prakash, Thazha P., Graham, Mark J., Yu, Jinghua, Carty, Rick, Low, Audrey, Chappell, Alfred, Schmidt, Karsten, Zhao, Chenguang, Aghajan, Mariam, Murray, Heather F., Riney, Stan, Booten, Sheri L., Murray, Susan F., Gaus, Hans, Crosby, Jeff, Lima, Walt F., Guo, Shuling, Monia, Brett P., Swayze, Eric E., Seth, Punit P.
Publicado 2014