Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases

por Limbocker, Ryan, Cremades, Nunilo, Cascella, Roberta, Tessier, Peter M., Vendruscolo, Michele, Chiti, Fabrizio
Publicado 2023

Localized Drug Application and Sub-Second Voltammetric Dopamine Release Measurements in a Brain Slice Perfusion Device

por Sun, Meng, Kaplan, Sam V., Gehringer, Rachel C., Limbocker, Ryan A., Johnson, Michael A.
Publicado 2014

Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation

por Joshi, Priyanka, Chia, Sean, Yang, Xiaoting, Perni, Michele, Gabriel, Justus M., Gilmer, Marshall, Limbocker, Ryan, Habchi, Johnny, Vendruscolo, Michele
Publicado 2023

Two human metabolites rescue a C. elegans model of Alzheimer’s disease via a cytosolic unfolded protein response

por Joshi, Priyanka, Perni, Michele, Limbocker, Ryan, Mannini, Benedetta, Casford, Sam, Chia, Sean, Habchi, Johnny, Labbadia, Johnathan, Dobson, Christopher M., Vendruscolo, Michele
Publicado 2021

Publisher Correction: Two human metabolites rescue a C. elegans model of Alzheimer’s disease via a cytosolic unfolded protein response

por Joshi, Priyanka, Perni, Michele, Limbocker, Ryan, Mannini, Benedetta, Casford, Sam, Chia, Sean, Habchi, Johnny, Labbadia, Johnathan, Dobson, Christopher M., Vendruscolo, Michele
Publicado 2021

Therapeutic Strategies to Reduce the Toxicity of Misfolded Protein Oligomers

por Kreiser, Ryan P., Wright, Aidan K., Block, Natalie R., Hollows, Jared E., Nguyen, Lam T., LeForte, Kathleen, Mannini, Benedetta, Vendruscolo, Michele, Limbocker, Ryan
Publicado 2020

Impaired Brain Dopamine and Serotonin Release and Uptake in Wistar Rats Following Treatment with Carboplatin

por Kaplan, Sam V., Limbocker, Ryan A., Gehringer, Rachel C., Divis, Jenny L., Osterhaus, Gregory L., Newby, Maxwell D., Sofis, Michael J., Jarmolowicz, David P., Newman, Brooke D., Mathews, Tiffany A., Johnson, Michael A.
Publicado 2016

A rationally designed bicyclic peptide remodels Aβ42 aggregation in vitro and reduces its toxicity in a worm model of Alzheimer’s disease

por Ikenoue, Tatsuya, Aprile, Francesco A., Sormanni, Pietro, Ruggeri, Francesco S., Perni, Michele, Heller, Gabriella T., Haas, Christian P., Middel, Christoph, Limbocker, Ryan, Mannini, Benedetta, Michaels, Thomas C. T., Knowles, Tuomas P. J., Dobson, Christopher M., Vendruscolo, Michele
Publicado 2020

Rationally Designed Antibodies as Research Tools to Study the Structure–Toxicity Relationship of Amyloid-β Oligomers

por Limbocker, Ryan, Mannini, Benedetta, Cataldi, Rodrigo, Chhangur, Shianne, Wright, Aidan K., Kreiser, Ryan P., Albright, J. Alex, Chia, Sean, Habchi, Johnny, Sormanni, Pietro, Kumita, Janet R., Ruggeri, Francesco S., Dobson, Christopher M., Chiti, Fabrizio, Aprile, Francesco A., Vendruscolo, Michele
Publicado 2020

Quantitative Attribution of the Protective Effects of Aminosterols against Protein Aggregates to Their Chemical Structures and Ability to Modulate Biological Membranes

por Errico, Silvia, Lucchesi, Giacomo, Odino, Davide, Osman, Enass Youssef, Cascella, Roberta, Neri, Lorenzo, Capitini, Claudia, Calamai, Martino, Bemporad, Francesco, Cecchi, Cristina, Kinney, William A., Barbut, Denise, Relini, Annalisa, Canale, Claudio, Caminati, Gabriella, Limbocker, Ryan, Vendruscolo, Michele, Zasloff, Michael, Chiti, Fabrizio
Publicado 2023

Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease

por Heller, Gabriella T., Aprile, Francesco A., Michaels, Thomas C. T., Limbocker, Ryan, Perni, Michele, Ruggeri, Francesco Simone, Mannini, Benedetta, Löhr, Thomas, Bonomi, Massimiliano, Camilloni, Carlo, De Simone, Alfonso, Felli, Isabella C., Pierattelli, Roberta, Knowles, Tuomas P. J., Dobson, Christopher M., Vendruscolo, Michele
Publicado 2020

Rational design of a conformation-specific antibody for the quantification of Aβ oligomers

por Aprile, Francesco A., Sormanni, Pietro, Podpolny, Marina, Chhangur, Shianne, Needham, Lisa-Maria, Ruggeri, Francesco S., Perni, Michele, Limbocker, Ryan, Heller, Gabriella T., Sneideris, Tomas, Scheidt, Tom, Mannini, Benedetta, Habchi, Johnny, Lee, Steven F., Salinas, Patricia C., Knowles, Tuomas P. J., Dobson, Christopher M., Vendruscolo, Michele
Publicado 2020

Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism

por Limbocker, Ryan, Mannini, Benedetta, Ruggeri, Francesco S., Cascella, Roberta, Xu, Catherine K., Perni, Michele, Chia, Sean, Chen, Serene W., Habchi, Johnny, Bigi, Alessandra, Kreiser, Ryan P., Wright, Aidan K., Albright, J. Alex, Kartanas, Tadas, Kumita, Janet R., Cremades, Nunilo, Zasloff, Michael, Cecchi, Cristina, Knowles, Tuomas P. J., Chiti, Fabrizio, Vendruscolo, Michele, Dobson, Christopher M.
Publicado 2020

A Brain-Permeable Aminosterol Regulates Cell Membranes to Mitigate the Toxicity of Diverse Pore-Forming Agents

por Kreiser, Ryan P., Wright, Aidan K., Sasser, Liam R., Rinauro, Dillon J., Gabriel, Justus M., Hsu, Claire M., Hurtado, Jorge A., McKenzie, Tristan L., Errico, Silvia, Albright, J. Alex, Richardson, Lance, Jaffett, Victor A., Riegner, Dawn E., Nguyen, Lam T., LeForte, Kathleen, Zasloff, Michael, Hollows, Jared E., Chiti, Fabrizio, Vendruscolo, Michele, Limbocker, Ryan
Publicado 2022

Trodusquemine enhances Aβ(42) aggregation but suppresses its toxicity by displacing oligomers from cell membranes

por Limbocker, Ryan, Chia, Sean, Ruggeri, Francesco S., Perni, Michele, Cascella, Roberta, Heller, Gabriella T., Meisl, Georg, Mannini, Benedetta, Habchi, Johnny, Michaels, Thomas C. T., Challa, Pavan K., Ahn, Minkoo, Casford, Samuel T., Fernando, Nilumi, Xu, Catherine K., Kloss, Nina D., Cohen, Samuel I. A., Kumita, Janet R., Cecchi, Cristina, Zasloff, Michael, Linse, Sara, Knowles, Tuomas P. J., Chiti, Fabrizio, Vendruscolo, Michele, Dobson, Christopher M.
Publicado 2019

Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers

por Limbocker, Ryan, Staats, Roxine, Chia, Sean, Ruggeri, Francesco S., Mannini, Benedetta, Xu, Catherine K., Perni, Michele, Cascella, Roberta, Bigi, Alessandra, Sasser, Liam R., Block, Natalie R., Wright, Aidan K., Kreiser, Ryan P., Custy, Edward T., Meisl, Georg, Errico, Silvia, Habchi, Johnny, Flagmeier, Patrick, Kartanas, Tadas, Hollows, Jared E., Nguyen, Lam T., LeForte, Kathleen, Barbut, Denise, Kumita, Janet R., Cecchi, Cristina, Zasloff, Michael, Knowles, Tuomas P. J., Dobson, Christopher M., Chiti, Fabrizio, Vendruscolo, Michele
Publicado 2021

Comparative Studies in the A30P and A53T α-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson's Disease

por Perni, Michele, van der Goot, Annemieke, Limbocker, Ryan, van Ham, Tjakko J., Aprile, Francesco A., Xu, Catherine K., Flagmeier, Patrick, Thijssen, Karen, Sormanni, Pietro, Fusco, Giuliana, Chen, Serene W., Challa, Pavan K., Kirkegaard, Julius B., Laine, Romain F., Ma, Kai Yu, Müller, Martin B. D., Sinnige, Tessa, Kumita, Janet R., Cohen, Samuel I. A., Seinstra, Renée, Kaminski Schierle, Gabriele S., Kaminski, Clemens F., Barbut, Denise, De Simone, Alfonso, Knowles, Tuomas P. J., Zasloff, Michael, Nollen, Ellen A. A., Vendruscolo, Michele, Dobson, Christopher M.
Publicado 2021