Pluripotent stem cell strategies for rebuilding the human brain

por Limone, Francesco, Klim, Joseph R., Mordes, Daniel A.
Publicado 2022

Cell-of-Origin-Specific 3D Genome Structure Acquired during Somatic Cell Reprogramming

por Krijger, Peter Hugo Lodewijk, Di Stefano, Bruno, de Wit, Elzo, Limone, Francesco, van Oevelen, Chris, de Laat, Wouter, Graf, Thomas
Publicado 2016

Considerations and practical implications of performing a phenotypic CRISPR/Cas survival screen

por Ashoti, Ator, Limone, Francesco, van Kranenburg, Melissa, Alemany, Anna, Baak, Mirna, Vivié, Judith, Piccioni, Frederica, Dijkers, Pascale F., Creyghton, Menno, Eggan, Kevin, Geijsen, Niels
Publicado 2022

Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients

por Mordes, Daniel A., Prudencio, Mercedes, Goodman, Lindsey D., Klim, Joseph R., Moccia, Rob, Limone, Francesco, Pietilainen, Olli, Chowdhary, Kaitavjeet, Dickson, Dennis W., Rademakers, Rosa, Bonini, Nancy M., Petrucelli, Leonard, Eggan, Kevin
Publicado 2018

De novo DNA methyltransferases DNMT3A and DNMT3B are essential for XIST silencing for erosion of dosage compensation in pluripotent stem cells

por Fukuda, Atsushi, Hazelbaker, Dane Z., Motosugi, Nami, Hao, Jin, Limone, Francesco, Beccard, Amanda, Mazzucato, Patrizia, Messana, Angelica, Okada, Chisa, San Juan, Irune Guerra, Qian, Menglu, Umezawa, Akihiro, Akutsu, Hidenori, Barrett, Lindy E., Eggan, Kevin
Publicado 2021

ALS IMPLICATED PROTEIN TDP-43 SUSTAINS LEVELS OF STMN2 A MEDIATOR OF MOTOR NEURON GROWTH AND REPAIR

por Klim, Joseph R., Williams, Luis A., Limone, Francesco, Juan, Irune Guerra San, Davis-Dusenbery, Brandi N., Mordes, Daniel A., Burberry, Aaron, Steinbaugh, Michael J., Gamage, Kanchana K., Kirchner, Rory, Moccia, Rob, Cassel, Seth H., Chen, Kuchuan, Wainger, Brian J., Woolf, Clifford J., Eggan, Kevin
Publicado 2019

Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission

por Nehme, Ralda, Zuccaro, Emanuela, Dia Ghosh, Sulagna, Li, Chenchen, Sherwood, John L., Pietilainen, Olli, Barrett, Lindy E., Limone, Francesco, Worringer, Kathleen A., Kommineni, Sravya, Zang, Ying, Cacchiarelli, Davide, Meissner, Alex, Adolfsson, Rolf, Haggarty, Stephen, Madison, Jon, Muller, Matthias, Arlotta, Paola, Fu, Zhanyan, Feng, Guoping, Eggan, Kevin
Publicado 2018

Efficient generation of lower induced motor neurons by coupling Ngn2 expression with developmental cues

por Limone, Francesco, Juan, Irune Guerra San, Mitchell, Jana M., Smith, Janell L.M., Raghunathan, Kavya, Meyer, Daniel, Ghosh, Sulagna Dia, Couto, Alexander, Klim, Joseph R., Joseph, Brian J., Gold, John, Mello, Curtis J., Nemesh, James, Smith, Brittany M., Verhage, Matthijs, McCarroll, Steven A., Pietiläinen, Olli, Nehme, Ralda, Eggan, Kevin
Publicado 2023

Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro

por Dolan, Michael-John, Therrien, Martine, Jereb, Saša, Kamath, Tushar, Gazestani, Vahid, Atkeson, Trevor, Marsh, Samuel E., Goeva, Aleksandrina, Lojek, Neal M., Murphy, Sarah, White, Cassandra M., Joung, Julia, Liu, Bingxu, Limone, Francesco, Eggan, Kevin, Hacohen, Nir, Bernstein, Bradley E., Glass, Christopher K., Leinonen, Ville, Blurton-Jones, Mathew, Zhang, Feng, Epstein, Charles B., Macosko, Evan Z., Stevens, Beth
Publicado 2023

Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes

por Rapino, Francesca, Natoli, Ted, Limone, Francesco, O’Connor, Erin, Blank, Jack, Tegtmeyer, Matthew, Chen, William, Norabuena, Erika, Narula, Juhi, Hazelbaker, Dane, Angelini, Gabriella, Barrett, Lindy, O’Neil, Alison, Beattie, Ursula K., Thanos, Jessica M., de Rivera, Heather, Sheridan, Steven D., Perlis, Roy H., McCarroll, Steven A., Stevens, Beth, Subramanian, Aravind, Nehme, Ralda, Rubin, Lee L.
Publicado 2022