Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and aged individuals

por Connors, Jennifer, Joyner, David, Mege, Nathan, Cusimano, Gina, Bell, Matthew, Marcy, Jennifer, Taramangalam, Bhavani, Lin, Paulo, Tam, Ying, Lin, Paulo, Weissman, Drew, Kutzler, Michele, Alameh, Mohamad-Gabriel, Haddad, Elias
Publicado 2022

Lipid Nanoparticle Delivery Systems to Enable mRNA-Based Therapeutics

por Semple, Sean C., Leone, Robert, Barbosa, Christopher J., Tam, Ying K., Lin, Paulo J. C.
Publicado 2022

mRNA vaccine with unmodified uridine induces robust type I interferon-dependent anti-tumor immunity in a melanoma model

por Sittplangkoon, Chutamath, Alameh, Mohamad-Gabriel, Weissman, Drew, Lin, Paulo J. C., Tam, Ying K., Prompetchara, Eakachai, Palaga, Tanapat
Publicado 2022

Lipid Nanoparticles Delivering Constitutively Active STING mRNA to Stimulate Antitumor Immunity

por Liu, Wei, Alameh, Mohamad-Gabriel, Yang, June F., Xu, Jonathan R., Lin, Paulo J. C., Tam, Ying K., Weissman, Drew, You, Jianxin
Publicado 2022

Lipid Nanoparticle Delivery of siRNA to Silence Neuronal Gene Expression in the Brain

por Rungta, Ravi L, Choi, Hyun B, Lin, Paulo JC, Ko, Rebecca WY, Ashby, Donovan, Nair, Jay, Manoharan, Muthiah, Cullis, Pieter R, MacVicar, Brian A
Publicado 2013

Protein corona: implications for nanoparticle interactions with pulmonary cells

por Konduru, Nagarjun V., Molina, Ramon M., Swami, Archana, Damiani, Flavia, Pyrgiotakis, Georgios, Lin, Paulo, Andreozzi, Patrizia, Donaghey, Thomas C., Demokritou, Philip, Krol, Silke, Kreyling, Wolfgang, Brain, Joseph D.
Publicado 2017

Exploring in vitro expression and immune potency in mice using mRNA encoding the Plasmodium falciparum malaria antigen, CelTOS

por Waghela, Ishita N., Mallory, Katherine L., Taylor, Justin A., Schneider, Cosette G., Savransky, Tatyana, Janse, Chris J., Lin, Paulo J. C., Tam, Ying K., Weissman, Drew, Angov, Evelina
Publicado 2022

Restoration of Motor Function through Delayed Intraspinal Delivery of Human IL-10-Encoding Nucleoside-Modified mRNA after Spinal Cord Injury

por Gál, László, Bellák, Tamás, Marton, Annamária, Fekécs, Zoltán, Weissman, Drew, Török, Dénes, Biju, Rachana, Vizler, Csaba, Kristóf, Rebeka, Beattie, Mitchell B., Lin, Paulo J.C., Pardi, Norbert, Nógrádi, Antal, Pajer, Krisztián
Publicado 2023

Author Correction: mRNA-LNP expressing PfCSP and Pfs25 vaccine candidates targeting infection and transmission of Plasmodium falciparum

por Hayashi, Clifford T. H., Cao, Yi, Clark, Leor C., Tripathi, Abhai K., Zavala, Fidel, Dwivedi, Garima, Knox, James, Alameh, Mohamad-Gabriel, Lin, Paulo J. C., Tam, Ying K., Weissman, Drew, Kumar, Nirbhay
Publicado 2023

mRNA-LNP expressing PfCSP and Pfs25 vaccine candidates targeting infection and transmission of Plasmodium falciparum

por Hayashi, Clifford T. H., Cao, Yi, Clark, Leor C., Tripathi, Abhai K., Zavala, Fidel, Dwivedi, Garima, Knox, James, Alameh, Mohamad-Gabriel, Lin, Paulo J. C., Tam, Ying K., Weissman, Drew, Kumar, Nirbhay
Publicado 2022

ESCRT recruitment to mRNA-encoded SARS-CoV-2 spike induces virus-like particles and enhanced antibody responses

por Hoffmann, Magnus A. G., Yang, Zhi, Huey-Tubman, Kathryn E., Cohen, Alexander A., Gnanapragasam, Priyanthi N. P., Nakatomi, Leesa M., Storm, Kaya N., Moon, Woohyun J., Lin, Paulo J.C., Bjorkman, Pamela J.
Publicado 2022

Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA

por Belliveau, Nathan M, Huft, Jens, Lin, Paulo JC, Chen, Sam, Leung, Alex KK, Leaver, Timothy J, Wild, Andre W, Lee, Justin B, Taylor, Robert J, Tam, Ying K, Hansen, Carl L, Cullis, Pieter R
Publicado 2012

ESCRT recruitment to SARS-CoV-2 spike induces virus-like particles that improve mRNA vaccines

por Hoffmann, Magnus A.G., Yang, Zhi, Huey-Tubman, Kathryn E., Cohen, Alexander A., Gnanapragasam, Priyanthi N.P., Nakatomi, Leesa M., Storm, Kaya N., Moon, Woohyun J., Lin, Paulo J.C., West, Anthony P., Bjorkman, Pamela J.
Publicado 2023

A Glu-urea-Lys Ligand-conjugated Lipid Nanoparticle/siRNA System Inhibits Androgen Receptor Expression In Vivo

por Lee, Justin B, Zhang, Kaixin, Tam, Yuen Yi C, Quick, Joslyn, Tam, Ying K, Lin, Paulo JC, Chen, Sam, Liu, Yan, Nair, Jayaprakash K, Zlatev, Ivan, Rajeev, Kallanthottathil G, Manoharan, Muthiah, Rennie, Paul S, Cullis, Pieter R
Publicado 2016

SARS-CoV-2 mRNA-based vaccines in the Aicardi Goutières Syndrome

por Takanohashi, Asako, Alameh, Mohamad-Gabriel, Woidill, Sarah, Hacker, Julia, Davis, Benjamin, Helman, Guy, Gavazzi, Francesco, Adang, Laura, D'Aiello, Russell, Winters, Patrick, Cordova, Devon, Khandaker, Taibeen, Ni, Houping, Tam, Ying, Lin, Paulo, Weissman, Drew, Shults, Justine, Vanderver, Adeline
Publicado 2022

Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and aged individuals

por Connors, Jennifer, Joyner, David, Mege, Nathan J., Cusimano, Gina M., Bell, Matthew R., Marcy, Jennifer, Taramangalam, Bhavani, Kim, Kenneth M., Lin, Paulo J. C., Tam, Ying K., Weissman, Drew, Kutzler, Michele A., Alameh, Mohamad-Gabriel, Haddad, Elias K.
Publicado 2023

Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice

por McKay, Paul F., Hu, Kai, Blakney, Anna K., Samnuan, Karnyart, Brown, Jonathan C., Penn, Rebecca, Zhou, Jie, Bouton, Clément R., Rogers, Paul, Polra, Krunal, Lin, Paulo J. C., Barbosa, Christopher, Tam, Ying K., Barclay, Wendy S., Shattock, Robin J.
Publicado 2020

In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA

por Villiger, Lukas, Rothgangl, Tanja, Witzigmann, Dominik, Oka, Rurika, Lin, Paulo J.C., Qi, Weihong, Janjuha, Sharan, Berk, Christian, Ringnalda, Femke, Beattie, Mitchell B., Stoffel, Markus, Thöny, Beat, Hall, Jonathan, Rehrauer, Hubert, van Boxtel, Ruben, Tam, Ying K., Schwank, Gerald
Publicado 2021

Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

por Mui, Barbara L, Tam, Ying K, Jayaraman, Muthusamy, Ansell, Steven M, Du, Xinyao, Tam, Yuen Yi C, Lin, Paulo JC, Chen, Sam, Narayanannair, Jayaprakash K, Rajeev, Kallanthottathil G, Manoharan, Muthiah, Akinc, Akin, Maier, Martin A, Cullis, Pieter, Madden, Thomas D, Hope, Michael J
Publicado 2013

A minimally-edited mouse model for infection with multiple SARS-CoV-2 strains

por Nakandakari-Higa, Sandra, Parsa, Roham, Reis, Bernardo S., de Carvalho, Renan V. H., Mesin, Luka, Hoffmann, Hans-Heinrich, Bortolatto, Juliana, Muramatsu, Hiromi, Lin, Paulo. J. C., Bilate, Angelina M., Rice, Charles M., Pardi, Norbert, Mucida, Daniel, Victora, Gabriel D., Canesso, Maria Cecilia C.
Publicado 2022