Nutrient deprivation induces α-synuclein aggregation through endoplasmic reticulum stress response and SREBP2 pathway

por Jiang, Peizhou, Gan, Ming, Lin, Wen-Lang, Yen, Shu-Hui C.
Publicado 2014

Clinicopathologic assessment and imaging of tauopathies in neurodegenerative dementias

por Murray, Melissa E, Kouri, Naomi, Lin, Wen-Lang, Jack, Clifford R, Dickson, Dennis W, Vemuri, Prashanthi
Publicado 2014

ER stress response plays an important role in aggregation of α-synuclein

por Jiang, Peizhou, Gan, Ming, Ebrahim, Abdul Shukkur, Lin, Wen-Lang, Melrose, Heather L, Yen, Shu-Hui C
Publicado 2010

Tangential Flow Filtration for Highly Efficient Concentration of Extracellular Vesicles from Large Volumes of Fluid

por Busatto, Sara, Vilanilam, George, Ticer, Taylor, Lin, Wen-Lang, Dickson, Dennis W., Shapiro, Shane, Bergese, Paolo, Wolfram, Joy
Publicado 2018

Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice

por Xu, Ya-Fei, Zhang, Yong-Jie, Lin, Wen-Lang, Cao, Xiangkun, Stetler, Caroline, Dickson, Dennis W, Lewis, Jada, Petrucelli, Leonard
Publicado 2011

Casein Kinase II Induced Polymerization of Soluble TDP-43 into Filaments Is Inhibited by Heat Shock Proteins

por Carlomagno, Yari, Zhang, Yongjie, Davis, Mary, Lin, Wen-Lang, Cook, Casey, Dunmore, Judy, Tay, William, Menkosky, Kyle, Cao, Xiangkun, Petrucelli, Leonard, DeTure, Michael
Publicado 2014

p62 Pathology Model in the Rat Substantia Nigra with Filamentous Inclusions and Progressive Neurodegeneration

por Jackson, Kasey L., Lin, Wen-Lang, Miriyala, Sumitra, Dayton, Robert D., Panchatcharam, Manikandan, McCarthy, Kevin J., Castanedes-Casey, Monica, Dickson, Dennis W., Klein, Ronald L.
Publicado 2017

Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse model

por Cook, Casey, Kang, Silvia S., Carlomagno, Yari, Lin, Wen-Lang, Yue, Mei, Kurti, Aishe, Shinohara, Mitsuru, Jansen-West, Karen, Perkerson, Emilie, Castanedes-Casey, Monica, Rousseau, Linda, Phillips, Virginia, Bu, Guojun, Dickson, Dennis W., Petrucelli, Leonard, Fryer, John D.
Publicado 2015

rAAV-based brain slice culture models of Alzheimer’s and Parkinson’s disease inclusion pathologies

por Croft, Cara L., Cruz, Pedro E., Ryu, Daniel H., Ceballos-Diaz, Carolina, Strang, Kevin H., Woody, Brittany M., Lin, Wen-Lang, Deture, Michael, Rodríguez-Lebrón, Edgardo, Dickson, Dennis W., Chakrabarty, Paramita, Levites, Yona, Giasson, Benoit I., Golde, Todd E.
Publicado 2019

ER–mitochondria associations are regulated by the VAPB–PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43

por Stoica, Radu, De Vos, Kurt J., Paillusson, Sébastien, Mueller, Sarah, Sancho, Rosa M., Lau, Kwok-Fai, Vizcay-Barrena, Gema, Lin, Wen-Lang, Xu, Ya-Fei, Lewis, Jada, Dickson, Dennis W., Petrucelli, Leonard, Mitchell, Jacqueline C., Shaw, Christopher E., Miller, Christopher C. J.
Publicado 2014

Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction

por Cannon, Ashley, Yang, Baoli, Knight, Joshua, Farnham, Ian M., Zhang, Yongjie, Wuertzer, Charles A., D’Alton, Simon, Lin, Wen-lang, Castanedes-Casey, Monica, Rousseau, Linda, Scott, Brittany, Jurasic, Michael, Howard, John, Yu, Xin, Bailey, Rachel, Sarkisian, Matthew R., Dickson, Dennis W., Petrucelli, Leonard, Lewis, Jada
Publicado 2012

LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors

por Hinkle, Kelly M, Yue, Mei, Behrouz, Bahareh, Dächsel, Justus C, Lincoln, Sarah J, Bowles, Erin E, Beevers, Joel E, Dugger, Brittany, Winner, Beate, Prots, Iryna, Kent, Caroline B, Nishioka, Kenya, Lin, Wen-Lang, Dickson, Dennis W, Janus, Christopher J, Farrer, Matthew J, Melrose, Heather L
Publicado 2012

Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy

por Clippinger, Amy K., D’Alton, Simon, Lin, Wen-Lang, Gendron, Tania F., Howard, John, Borchelt, David R., Cannon, Ashley, Carlomagno, Yari, Chakrabarty, Paramita, Cook, Casey, Golde, Todd E., Levites, Yona, Ranum, Laura, Schultheis, Patrick J., Xu, Guilian, Petrucelli, Leonard, Sahara, Naruhiko, Dickson, Dennis W., Giasson, Benoit, Lewis, Jada
Publicado 2013

Vascular Collagen Type-IV in Hypertension and Cerebral Small Vessel Disease

por Kumar, Apoorva A., Yeo, Natalie, Whittaker, Max, Attra, Priya, Barrick, Thomas R., Bridges, Leslie R., Dickson, Dennis W., Esiri, Margaret M., Farris, Chad W., Graham, Delyth, Lin, Wen Lang, Meijles, Daniel N., Pereira, Anthony C., Perry, Gregory, Rosene, Douglas L., Shtaya, Anan B., Van Agtmael, Tom, Zamboni, Giovanna, Hainsworth, Atticus H.
Publicado 2022

Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress

por Zhang, Yong-Jie, Jansen-West, Karen, Xu, Ya-Fei, Gendron, Tania F., Bieniek, Kevin F., Lin, Wen-Lang, Sasaguri, Hiroki, Caulfield, Thomas, Hubbard, Jaime, Daughrity, Lillian, Chew, Jeannie, Belzil, Veronique V., Prudencio, Mercedes, Stankowski, Jeannette N., Castanedes-Casey, Monica, Whitelaw, Ena, Ash, Peter E. A., DeTure, Michael, Rademakers, Rosa, Boylan, Kevin B., Dickson, Dennis W., Petrucelli, Leonard
Publicado 2014

Mitophagy alterations in Alzheimer's disease are associated with granulovacuolar degeneration and early tau pathology

por Hou, Xu, Watzlawik, Jens O., Cook, Casey, Liu, Chia‐Chen, Kang, Silvia S., Lin, Wen‐Lang, DeTure, Michael, Heckman, Michael G., Diehl, Nancy N., Al‐Shaikh, Fadi S. Hanna, Walton, Ronald L., Ross, Owen A., Melrose, Heather L., Ertekin‐Taner, Nilüfer, Bu, Guojun, Petrucelli, Leonard, Fryer, John D., Murray, Melissa E., Dickson, Dennis W., Fiesel, Fabienne C., Springer, Wolfdieter
Publicado 2020

Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease

por Hou, Xu, Fiesel, Fabienne C., Truban, Dominika, Castanedes Casey, Monica, Lin, Wen-lang, Soto, Alexandra I., Tacik, Pawel, Rousseau, Linda G., Diehl, Nancy N., Heckman, Michael G., Lorenzo-Betancor, Oswaldo, Ferrer, Isidre, Arbelo, José M., Steele, John C., Farrer, Matthew J., Cornejo-Olivas, Mario, Torres, Luis, Mata, Ignacio F., Graff-Radford, Neill R., Wszolek, Zbigniew K., Ross, Owen A., Murray, Melissa E., Dickson, Dennis W., Springer, Wolfdieter
Publicado 2018

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

por Murakami, Tetsuro, Qamar, Seema, Lin, Julie Qiaojin, Schierle, Gabriele S. Kaminski, Rees, Eric, Miyashita, Akinori, Costa, Ana R., Dodd, Roger B., Chan, Fiona T.S., Michel, Claire H., Kronenberg-Versteeg, Deborah, Li, Yi, Yang, Seung-Pil, Wakutani, Yosuke, Meadows, William, Ferry, Rodylyn Rose, Dong, Liang, Tartaglia, Gian Gaetano, Favrin, Giorgio, Lin, Wen-Lang, Dickson, Dennis W., Zhen, Mei, Ron, David, Schmitt-Ulms, Gerold, Fraser, Paul E., Shneider, Neil A., Holt, Christine, Vendruscolo, Michele, Kaminski, Clemens F., St George-Hyslop, Peter
Publicado 2015