Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate

por Park, Jaeok, Lin, Yih-Shyan, Tsantrizos, Youla S., Berghuis, Albert M.
Publicado 2014

Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme’s a...

por Park, Jaeok, Lin, Yih-Shyan, De Schutter, Joris W, Tsantrizos, Youla S, Berghuis, Albert M
Publicado 2012

Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase

por Park, Jaeok, Rodionov, Dmitry, De Schutter, Joris W., Lin, Yih-Shyan, Tsantrizos, Youla S., Berghuis, Albert M.
Publicado 2017

Development of Furanopyrimidine-Based Orally Active Third-Generation EGFR Inhibitors for the Treatment of Non-Small Cell Lung Cancer

por Li, Mu-Chun, Coumar, Mohane Selvaraj, Lin, Shu-Yu, Lin, Yih-Shyan, Huang, Guan-Lin, Chen, Chun-Hwa, Lien, Tzu-Wen, Wu, Yi-Wen, Chen, Yen-Ting, Chen, Ching-Ping, Huang, Yu-Chen, Yeh, Kai-Chia, Yang, Chen-Ming, Kalita, Bikashita, Pan, Shiow-Lin, Hsu, Tsu-An, Yeh, Teng-Kuang, Chen, Chiung-Tong, Hsieh, Hsing-Pang
Publicado 2023