Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC

por Zeng, Hao, Castillo-Cabrera, Johnny, Manser, Mika, Lu, Bo, Yang, Zinger, Strande, Vaik, Begue, Damien, Zamponi, Raffaella, Qiu, Shumei, Sigoillot, Frederic, Wang, Qiong, Lindeman, Alicia, Reece-Hoyes, John S, Russ, Carsten, Bonenfant, Debora, Jiang, Xiaomo, Wang, Youzhen, Cong, Feng
Publicado 2019

Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy

por Potting, Christoph, Crochemore, Christophe, Moretti, Francesca, Nigsch, Florian, Schmidt, Isabel, Manneville, Carole, Carbone, Walter, Knehr, Judith, DeJesus, Rowena, Lindeman, Alicia, Maher, Rob, Russ, Carsten, McAllister, Gregory, Reece-Hoyes, John S., Hoffman, Gregory R., Roma, Guglielmo, Müller, Matthias, Sailer, Andreas W., Helliwell, Stephen B.
Publicado 2018

Cell adhesion molecule KIRREL1 is a feedback regulator of Hippo signaling recruiting SAV1 to cell-cell contact sites

por Paul, Atanu, Annunziato, Stefano, Lu, Bo, Sun, Tianliang, Evrova, Olivera, Planas-Paz, Lara, Orsini, Vanessa, Terracciano, Luigi M., Charlat, Olga, Loureiro, Zinger Yang, Ji, Lei, Zamponi, Raffaella, Sigoillot, Frederic, Lei, Hong, Lindeman, Alicia, Russ, Carsten, Reece-Hoyes, John S., Nicholson, Thomas B., Tchorz, Jan S., Cong, Feng
Publicado 2022

Cancer lineage-specific regulation of YAP responsive elements revealed through large-scale functional epigenomic screens

por Barbosa, Inês A. M., Gopalakrishnan, Rajaraman, Mercan, Samuele, Mourikis, Thanos P., Martin, Typhaine, Wengert, Simon, Sheng, Caibin, Ji, Fei, Lopes, Rui, Knehr, Judith, Altorfer, Marc, Lindeman, Alicia, Russ, Carsten, Naumann, Ulrike, Golji, Javad, Sprouffske, Kathleen, Barys, Louise, Tordella, Luca, Schübeler, Dirk, Schmelzle, Tobias, Galli, Giorgio G.
Publicado 2023

TRRAP is a central regulator of human multiciliated cell formation

por Wang, Zhao, Plasschaert, Lindsey W., Aryal, Shivani, Renaud, Nicole A., Yang, Zinger, Choo-Wing, Rayman, Pessotti, Angelica D., Kirkpatrick, Nathaniel D., Cochran, Nadire R., Carbone, Walter, Maher, Rob, Lindeman, Alicia, Russ, Carsten, Reece-Hoyes, John, McAllister, Gregory, Hoffman, Gregory R., Roma, Guglielmo, Jaffe, Aron B.
Publicado 2018

Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons

por Sanchez, Carlos G., Acker, Christopher M., Gray, Audrey, Varadarajan, Malini, Song, Cheng, Cochran, Nadire R., Paula, Steven, Lindeman, Alicia, An, Shaojian, McAllister, Gregory, Alford, John, Reece-Hoyes, John, Russ, Carsten, Craig, Lucas, Capre, Ketthsy, Doherty, Christian, Hoffman, Gregory R., Luchansky, Sarah J., Polydoro, Manuela, Dolmetsch, Ricardo, Elwood, Fiona
Publicado 2021

DRUG-seq Provides Unbiased Biological Activity Readouts for Neuroscience Drug Discovery

por Li, Jingyao, Ho, Daniel J., Henault, Martin, Yang, Chian, Neri, Marilisa, Ge, Robin, Renner, Steffen, Mansur, Leandra, Lindeman, Alicia, Kelly, Brian, Tumkaya, Tayfun, Ke, Xiaoling, Soler-Llavina, Gilberto, Shanker, Gopi, Russ, Carsten, Hild, Marc, Gubser Keller, Caroline, Jenkins, Jeremy L., Worringer, Kathleen A., Sigoillot, Frederic D., Ihry, Robert J.
Publicado 2022

An iron-dependent metabolic vulnerability underlies VPS34-dependence in RKO cancer cells

por Kobylarz, Marek J., Goodwin, Jonathan M., Kang, Zhao B., Annand, John W., Hevi, Sarah, O’Mahony, Ellen, McAllister, Gregory, Reece-Hoyes, John, Wang, Qiong, Alford, John, Russ, Carsten, Lindeman, Alicia, Beibel, Martin, Roma, Guglielmo, Carbone, Walter, Knehr, Judith, Loureiro, Joseph, Antczak, Christophe, Wiederschain, Dmitri, Murphy, Leon O., Menon, Suchithra, Nyfeler, Beat
Publicado 2020

Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62

por DeJesus, Rowena, Moretti, Francesca, McAllister, Gregory, Wang, Zuncai, Bergman, Phil, Liu, Shanming, Frias, Elizabeth, Alford, John, Reece-Hoyes, John S, Lindeman, Alicia, Kelliher, Jennifer, Russ, Carsten, Knehr, Judith, Carbone, Walter, Beibel, Martin, Roma, Guglielmo, Ng, Aylwin, Tallarico, John A, Porter, Jeffery A, Xavier, Ramnik J, Mickanin, Craig, Murphy, Leon O, Hoffman, Gregory R, Nyfeler, Beat
Publicado 2016

Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells

por Estoppey, David, Hewett, Jeffrey W., Guy, Chantale T., Harrington, Edmund, Thomas, Jason R., Schirle, Markus, Cuttat, Rachel, Waldt, Annick, Gerrits, Bertran, Yang, Zinger, Schuierer, Sven, Pan, Xuewen, Xie, Kevin, Carbone, Walter, Knehr, Judith, Lindeman, Alicia, Russ, Carsten, Frias, Elizabeth, Hoffman, Gregory R., Varadarajan, Malini, Ramadan, Nadire, Reece-Hoyes, John S., Wang, Qiong, Chen, Xin, McAllister, Gregory, Roma, Guglielmo, Bouwmeester, Tewis, Hoepfner, Dominic
Publicado 2017